We are analyzing https://link.springer.com/article/10.1007/s11033-012-2024-y.

Title:
Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature | Molecular Biology Reports
Description:
The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
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cancer, google, scholar, pubmed, article, breast, cas, vascular, endothelial, growth, expression, lymphatic, prognostic, lymphangiogenesis, vegfc, metastasis, factor, res, density, wang, metaanalysis, microvessel, carcinoma, factors, survival, cell, patients, tumor, pathol, factorc, clin, lung, significance, review, literature, guo, prognosis, human, lymph, systematic, oncol, alitalo, node, chen, receptor, yang, van, study, vegfd, tumors,

Topics {✒️}

including disease-free survival month download article/chapter virus-mediated gene transfer rna-binding protein hur small-cell lung carcinoma meta-analysis confirms bcl2 prognosis meta-analysis access vegf-d-positive tumors breast cancer—10 years follow vegf-c-positive tumor full article pdf lymphatic endothelial cells electronic databases pubmed vegf-family gene expression hypoxia-inducible factor hypoxia inducible factor privacy choices/manage cookies lymphatic vascular specificity lymphangiogenic growth factors lymphatic vessel density lymphatic microvessel density lymphangiogenic microvessel density van laere sj peritumoral lymphatic density blood vascular densities blood vessel density human disease van marck ea ductal breast carcinoma lymphatic endothelial regulation invasive breast carcinomas ductal breast cancer weak prognostic factor long-term prognosis lymph-specific receptor long-term follow sentinel lymph nodes pro-lymphangiogenic mediators invasive breast carcinoma lymph node metastasis promotes lymphatic metastasis mouse lung adenocarcinoma blood vessel morphometry human breast carcinoma murine lymphatic system european economic area pooled hazard ratio predict poor prognosis adjuvant systemic therapy dose-dependent response

Questions {❓}

Colozza M, Azambuja E, Cardoso F, Sotiriou C, Larsimont D, Piccart MJ (2005) Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?

Schema {🗺️}

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         description:The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
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      description:The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
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         Animal Anatomy / Morphology / Histology
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