We are analyzing https://link.springer.com/article/10.1007/s11033-009-9819-5.

Title:
Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway | Molecular Biology Reports
Description:
Disorders in the proliferation and apoptosis of thyrocytes may induce goitre, adenoma and carcinoma in the thyroid. The Wnt/beta-catenin pathway has been demonstrated to be involved in the regulation of cell proliferation, differentiation and apoptosis in various cell lines. The regulatory mechanism on the proliferation and differentiation of thyrocytes is not well characterized. In the present study, a GSK-3beta-targeting RNA interference (RNAi) adenovirus vector was constructed and delivered to primary human thyrocytes. Results showed that the expression of beta-catenin protein in primary human thyrocytes was increased after GSK-3beta-targeting RNAi adenovirus infection, the proliferation of primary human thyrocytes was significantly stimulated using Bromodeoxyuridine (BrdU) assay, while cell apoptosis was slightly affected which was observed through flow cytometry. It is concluded that the Wnt/beta-catenin pathway plays a significant role in the regulation of the proliferation of primary human thyrocytes.
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article, pubmed, google, scholar, cas, thyroid, proliferation, thyrocytes, human, apoptosis, wntbetacatenin, lin, access, signaling, pathway, cell, cancer, privacy, cookies, content, regulation, rnai, primary, betacatenin, endocrinol, information, publish, search, gsk, beta, adenovirus, expression, chen, jiang, junping, carcinoma, cells, open, growth, data, log, journal, research, biology, vector, september, gang, qiqin, zhenhui, jin,

Topics {✒️}

gsk-3beta-targeting rna interference wnt/beta-catenin pathway published wnt/beta-catenin pathway plays wnt/beta-catenin signaling pathway activating wnt/beta-catenin signalling wnt/beta-catenin pathway month download article/chapter wnt/beta-catenin signaling tgf-β induces emt junping wen & lixiang lin beta-cell biology beta-catenin expression thyroid cancer cells beta-catenin protein human thyroid cells full article pdf related subjects junping wen contributed gsk-3 beta privacy choices/manage cookies human thyrocytes investigated primary human thyrocytes adenovirus vector anti-cancer activity fujian provincial hospital anaplastic thyroid carcinoma lithium stimulates proliferation thyroid follicular lesions beta-catenin fujian medical university wnt signaling cell apoptosis article chen european economic area andrographolide analogue functions primary murine fibroblasts junping wen check access instant access thyroid cancer conditions privacy policy cell proliferation electronic supplementary material lixiang lin author information authors accepting optional cookies main content log article log rnai journal finder publish

Schema {🗺️}

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         headline:Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway
         description:Disorders in the proliferation and apoptosis of thyrocytes may induce goitre, adenoma and carcinoma in the thyroid. The Wnt/beta-catenin pathway has been demonstrated to be involved in the regulation of cell proliferation, differentiation and apoptosis in various cell lines. The regulatory mechanism on the proliferation and differentiation of thyrocytes is not well characterized. In the present study, a GSK-3beta-targeting RNA interference (RNAi) adenovirus vector was constructed and delivered to primary human thyrocytes. Results showed that the expression of beta-catenin protein in primary human thyrocytes was increased after GSK-3beta-targeting RNAi adenovirus infection, the proliferation of primary human thyrocytes was significantly stimulated using Bromodeoxyuridine (BrdU) assay, while cell apoptosis was slightly affected which was observed through flow cytometry. It is concluded that the Wnt/beta-catenin pathway plays a significant role in the regulation of the proliferation of primary human thyrocytes.
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            GSK-3beta
            Human thyrocytes
            Proliferation
            Apoptosis
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
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      headline:Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway
      description:Disorders in the proliferation and apoptosis of thyrocytes may induce goitre, adenoma and carcinoma in the thyroid. The Wnt/beta-catenin pathway has been demonstrated to be involved in the regulation of cell proliferation, differentiation and apoptosis in various cell lines. The regulatory mechanism on the proliferation and differentiation of thyrocytes is not well characterized. In the present study, a GSK-3beta-targeting RNA interference (RNAi) adenovirus vector was constructed and delivered to primary human thyrocytes. Results showed that the expression of beta-catenin protein in primary human thyrocytes was increased after GSK-3beta-targeting RNAi adenovirus infection, the proliferation of primary human thyrocytes was significantly stimulated using Bromodeoxyuridine (BrdU) assay, while cell apoptosis was slightly affected which was observed through flow cytometry. It is concluded that the Wnt/beta-catenin pathway plays a significant role in the regulation of the proliferation of primary human thyrocytes.
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      name:Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
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