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igf-2r/pka/sp1/erp29/ip3r2 pathway-mediated impairment ampk/nf-κb/nlrp3 signaling pathway upregulated anti-angiogenic mir-424-5p postoperative cd8 + t-cell infiltration month download article/chapter tissue-infiltrating th1/th17 cells blood-brain barrier disturbances inhibiting tlr4/hif-1α gly-ldl-induced huvecs pi3k/akt/foxo1 pathway inhibiting t-cell proliferation central nervous system obesity-induced airway hyperresponsiveness diabetes-induced cognitive impairment hong guo & qingsheng yin proteinopathies-driven immune disorders tnfα-stimulated endothelial cells effector t-cell trafficking cell-related molecular biomarkers aging-based community cohort single-cell analysis reveals t-cell senescence contributes il-17/cebpβ/c3 pathway choroid plexus-selective inactivation brain antigen-reactive cd4 + high-dose oral insulin component-based chinese medicine induces regulatory tolerance blood-brain barrier diet-induced obese mice full article pdf central neuroimmune mechanisms ameliorate blood glucose helper cell-related factors meningeal lymphatic vessels abnormal glucose homeostasis altered t-cell subsets aberrant nkg2d expression immune cells contribute peripheral blood inkt paracrine mechanism mediated dipeptidyl peptidase-4 inhibitor garcia-vallejo jj adaptive immune system central system peripheral blood il-22 neuroinflammation-induced lymphangiogenesis peptide-1 receptor agonists immune tolerance il-17-producing treg cells

Questions {❓}

• Copp G, Robb KP, Viswanathan S (2023) Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis?
• Velloso LA, Eizirik DL, Cnop M (2013) Type 2 diabetes mellitus–an autoimmune disease?

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         description:Diabetic cognitive impairment (DCI) is a central nervous system complication induced by peripheral metabolic dysfunction of diabetes mellitus. Cumulative studies have shown that neuro-immune crosstalk is involved in the pathological progression of DCI. However, current studies mostly focus on the interaction between innate immunity cells and neurons, while ignoring the role of adaptive immunity cells in DCI. Notably, recent studies have revealed adaptive immune cells are involved in cognitive development and the progression of neurodegenerative diseases. Equally important, accumulated past studies have also shown that diabetic patients experience imbalanced peripheral adaptive immune homeostasis and disrupted transmission of adaptive immune cells to the central system. Therefore, this review first updated the cognitive mechanism of adaptive immune regulation, and then summarized the contribution of adaptive immunity to DCI from the aspects of peripheral adaptive immune homeostasis, transmission pathways, and brain tissue infiltration. Furthermore, we also summarized the potential of anti-diabetic drugs to regulate adaptive immunity, and looked forward to the potential value of regulatory adaptive immunity in the prevention and treatment of DCI, to provide a new strategy for the prevention and treatment of DCI.
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            address:
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            address:
               name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
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            address:
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            address:
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            address:
               name:National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
               type:PostalAddress
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      name:Hong Guo
      affiliation:
            name:Tianjin University of Traditional Chinese Medicine
            address:
               name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
               type:PostalAddress
            type:Organization
            name:Tianjin University of Traditional Chinese Medicine
            address:
               name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
               type:PostalAddress
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      email:[email protected]
      name:Qingsheng Yin
      url:http://orcid.org/0000-0002-8577-5539
      affiliation:
            name:Tianjin University of Traditional Chinese Medicine
            address:
               name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
               type:PostalAddress
            type:Organization
            name:Tianjin University of Traditional Chinese Medicine
            address:
               name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
               type:PostalAddress
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      email:[email protected]
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      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
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      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
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      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
      name:National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin, China
      name:Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
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