We are analyzing https://link.springer.com/article/10.1007/s11010-025-05316-w.

Title:
Nuclear-localized metabolic enzymes: emerging key players in tumor epigenetic regulation | Molecular and Cellular Biochemistry
Description:
Advancements in tumor research have highlighted the potential of epigenetic therapies as a targeted approach to cancer treatment. However, the application of these therapies has faced challenges due to the issue of substrate availability since the discovery of epigenetic modifications. Interestingly, metabolic changes are closely associated with epigenetic changes, and notably, certain metabolic enzymes exhibit nuclear localization within epigenetically active cellular contexts. This suggests that nuclear localization of metabolic enzymes may provide a mechanistic foundation for addressing substrate availability issues in epigenetic regulation. To date, there has been limited progress in synthesizing this information systematically. In this study, we provide an overview of the interplay between metabolic enzymes and epigenetic mechanisms, highlighting their critical roles. Subsequently, we summarize recent advances regarding the nuclear localization of metabolic enzymes, shedding light on their emerging roles in epigenetic regulation and oncogenesis. Graphical abstract
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, wang, cell, zhang, httpsdoiorgs, liu, chen, nat, yang, histone, epigenetic, metabolic, metabolism, res, dna, biol, tumor, zhou, mol, cells, lactate, nuclear, epigenetics, rev, dehydrogenase, enzymes, huang, med, nature, clin, zhao, regulation, lin, human, jiang, exp, sun, gene, demethylation, promotes, therapeutic, gao, pyruvate, mechanisms,

Topics {✒️}

histone post-translational modifications month download article/chapter α-ketoglutarate-dependent dioxygenases nuclear-localized metabolic enzymes regulates tumor-macrophage symbiosis ttf-1-negative lung adenocarcinomas kdm4/jmjd2 histone demethylases histone acetyltransferases cbp/p300 van den bent pdpk1/akt/gcn5 axis idh2 mutation-induced histone vitamin-c-dependent manner early-life environmental exposure mir-200c reprograms fibroblasts hematopoietic stem/progenitor cells tet-tdg functional reactivation h3k36me2-specific demethylase ezh2–eed interaction inhibitors full article pdf tumor-infiltrating myeloid cells sun yat-sen university hif-1α pathway multiple myeloma cells akt signaling pathways de blasio mj atp-citrate lyase atp citrate lyase febs open bio acute myeloid leukemia cardiac mesenchymal cells cellular biochemistry aims epithelial-mesenchymal transition weixi yuan jarid1 histone demethylases kdm7 histone demethylases hexokinase2-mediated phosphorylation facilitate gene expression promotes gene transcription privacy choices/manage cookies energy metabolism metabolic enzymes moonlighting inhibiting ribosome biogenesis p53 dependent manner cbp/p300 inhibitors suppresses homologous recombination produce α-hydroxybutyrate warburg effect enhanced dna repair factors dna replication past glucose metabolic enzymes

Questions {❓}

Ling C, Bacos K, Rönn T (2022) Epigenetics of Type 2 diabetes mellitus and weight change—a tool for precision medicine?
Van den Bent MJ, French PJ, Brat D, Tonn JC, Touat M, Ellingson BM, Young RJ, Pallud J, von Deimling A, Sahm F, Figarella Branger D, Huang RY, Weller M, Mellinghoff IK, Cloughsey TF, Huse JT, Aldape K, Reifenberger G, Youssef G, Karschnia P, Noushmehr H, Peters KB, Ducray F, Preusser M, Wen PY (2024) The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: how should they inform treatment decisions in the era of IDH inhibitors?

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