We are analyzing https://link.springer.com/article/10.1007/s11010-025-05308-w.

Title:
CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer | Molecular and Cellular Biochemistry
Description:
Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, reported in gastrointestinal malignancies, contribute to ET resistance mechanisms in breast cancer. Although no CD44-SLC1A2 fusions were detected, high expression of CD44 and SLC1A2 was associated with poor survival outcomes and identified a therapy-resistant subpopulation sustained by aspartate and glutamate metabolism, highlighting potential metabolic vulnerabilities for future therapeutic intervention.
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Keywords {🔍}

slca, cancer, breast, cells, analysis, article, pubmed, expression, resistance, fig, cdslca, google, scholar, data, fusion, levels, protein, mcflted, subjected, cas, cancers, qrtpcr, bacci, endocrine, reported, total, therapy, gene, fusions, aspartate, metabolic, central, access, lorito, western, antibodies, sictr, patients, open, glutamate, cell, blot, rna, transfected, mrna, bonechi, smiriglia, clinical, potential, estrogen,

Topics {✒️}

log-rank mantel–cox p-values �ministero dell’istruzione dell’università long-term estrogen deprived long-term estrogen deprivation custom-designed taqman probe quantitative real-time pcr precast sds-page gels lipid droplet-peroxisome axis tata-box binding protein proteasome inhibitor mg-132 post-transcriptional regulation mechanism triple-negative breast cancer therapy-resistant subpopulation sustained patient-level meta-analysis cd44-slc1a2 fusion variant cd44-slc1a2 fusion transcripts slc1a2-cd44 fusion mrna er+ breast cancer er breast cancer endocrine-resistant er anti-oestrogen therapy resistant breast cancers article download pdf breast cancer patients aspartate/glutamate deprivation led cd44-slc1a2 gene fusions mcf7-lted cells transfected full access custom-designed assay breast cancer subtypes breast cancer cells privacy choices/manage cookies slc1a2-cd44 fusion transcript future therapeutic intervention related subjects guiding therapeutic strategies fondazione cr firenze cdk4/6 inhibitor palbociclib glucose metabolic reprogramming western blot analysis mcf7-lted cells subjected amino acid transporters health” ecs00000017 funded protein levels compared er+ breast tumors cellular biochemistry aims fondazione radioterapia oncologica endogenous metabolic limitation bmc cancer 12 primary colorectal cancer

Schema {🗺️}

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         headline:CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer
         description:Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, reported in gastrointestinal malignancies, contribute to ET resistance mechanisms in breast cancer. Although no CD44-SLC1A2 fusions were detected, high expression of CD44 and SLC1A2 was associated with poor survival outcomes and identified a therapy-resistant subpopulation sustained by aspartate and glutamate metabolism, highlighting potential metabolic vulnerabilities for future therapeutic intervention.
         datePublished:2025-05-23T00:00:00Z
         dateModified:2025-05-23T00:00:00Z
         pageStart:1
         pageEnd:7
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            Endocrine therapy
            Metabolic reprogramming
            Biochemistry
            general
            Cardiology
            Cancer Research
            Medical Biochemistry
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ScholarlyArticle:
      headline:CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer
      description:Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, reported in gastrointestinal malignancies, contribute to ET resistance mechanisms in breast cancer. Although no CD44-SLC1A2 fusions were detected, high expression of CD44 and SLC1A2 was associated with poor survival outcomes and identified a therapy-resistant subpopulation sustained by aspartate and glutamate metabolism, highlighting potential metabolic vulnerabilities for future therapeutic intervention.
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      dateModified:2025-05-23T00:00:00Z
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         Endocrine therapy
         Metabolic reprogramming
         Biochemistry
         general
         Cardiology
         Cancer Research
         Medical Biochemistry
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         name:Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
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      name:Edoardo Pagliantini
      affiliation:
            name:University of Florence
            address:
               name:Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
               type:PostalAddress
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      affiliation:
            name:University of Florence
            address:
               name:Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
               type:PostalAddress
            type:Organization
      name:Icro Meattini
      affiliation:
            name:University of Florence
            address:
               name:Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
               type:PostalAddress
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            name:Azienda Ospedaliero Universitaria Careggi
            address:
               name:Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
               type:PostalAddress
            type:Organization
      name:Andrea Morandi
      affiliation:
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            address:
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      name:Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
      name:Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
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