We are analyzing https://link.springer.com/article/10.1007/s11010-012-1332-9.

Title:
KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells | Molecular and Cellular Biochemistry
Description:
Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, pubmed, cas, google, scholar, klf, vascular, smooth, muscle, cells, hhlim, zheng, factor, cell, proliferation, growth, han, biol, access, chem, physiol, privacy, cookies, content, miao, liu, neointimal, formation, protein, interaction, cyclin, promoter, expression, transcription, zhang, data, publish, search, cellular, biochemistry, heart, pdgfbb, binding, inhibits, dong, function, information, log, journal, research,

Topics {✒️}

tgf-β control element nf-kappab regulating cell cycle month download article/chapter protein kinase c-delta p15 transcription factors erk-dependent rna turn yan liu & bin zheng pro-proliferative factor klf5 pdgf-bb promoted pdgf-bb represses cell-cell adhesion cell growth autocrine growth mechanisms full article pdf related subjects signaling-mediated modification privacy choices/manage cookies tgf-beta adenovirus-mediated overexpression klf1 impair expression matrix metalloproteinase expression embryonic stem cells cell proliferation article shi klf5-dependent manner c-jun leading actin cytoskeleton remodeling hebei medical university decreased neointimal formation check access instant access european economic area oncogenic regulator set dna-binding domain cis-dna elements drosophila double-parked zhongshan east road article molecular stimulating hhlim binding conditions privacy policy sm22{alpha} promoter reverse hhlim function sui-bing miao bin zheng accepting optional cookies jin-kun wen cellular biochemistry aims mechanistic studies suggested atra activates

Schema {🗺️}

WebPage:
      mainEntity:
         headline:KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
         description:Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
         datePublished:2012-05-15T00:00:00Z
         dateModified:2012-05-15T00:00:00Z
         pageStart:185
         pageEnd:194
         sameAs:https://doi.org/10.1007/s11010-012-1332-9
         keywords:
            KLF5
            PDGF-BB
            hhLIM
            VSMC
            TGF-β control element
            Biochemistry
            general
            Cardiology
            Cancer Research
            Medical Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig5_HTML.gif
         isPartOf:
            name:Molecular and Cellular Biochemistry
            issn:
               1573-4919
               0300-8177
            volumeNumber:367
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hui-jing Shi
               affiliation:
                     name:Hebei Medical University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jin-kun Wen
               affiliation:
                     name:Hebei Medical University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sui-bing Miao
               affiliation:
                     name:Hebei Medical University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan Liu
               affiliation:
                     name:Hebei Medical University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bin Zheng
               affiliation:
                     name:Hebei Medical University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
      description:Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while human heart LIM protein (hhLIM) decreased neointimal formation following vascular injury. Interestingly, neointimal formation was significantly increased in the animals where both hhLIM and KLF5 were introduced, suggesting that KLF5 can reverse hhLIM function in cell proliferation on the coexpression with hhLIM. These results were also confirmed the cellular level. Further mechanistic studies suggested that PDGF-BB promoted the interaction between hhLIM and KLF5 through stimulating hhLIM binding to TGF-β control element (TCE) on the cyclin E promoter in a KLF5-dependent manner. Failure of KLF5 binding to the TCE, on the knockdown of KLF5 by transfecting siRNA, not only prevented the recruitment of hhLIM to the cyclin E promoter but also affected activation of the cyclin E promoter by KLF5. These data suggest that KLF5 reverses hhLIM function from anti-proliferation to pro-proliferation through its interaction with hhLIM on the cyclin E promoter.
      datePublished:2012-05-15T00:00:00Z
      dateModified:2012-05-15T00:00:00Z
      pageStart:185
      pageEnd:194
      sameAs:https://doi.org/10.1007/s11010-012-1332-9
      keywords:
         KLF5
         PDGF-BB
         hhLIM
         VSMC
         TGF-β control element
         Biochemistry
         general
         Cardiology
         Cancer Research
         Medical Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-012-1332-9/MediaObjects/11010_2012_1332_Fig5_HTML.gif
      isPartOf:
         name:Molecular and Cellular Biochemistry
         issn:
            1573-4919
            0300-8177
         volumeNumber:367
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hui-jing Shi
            affiliation:
                  name:Hebei Medical University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jin-kun Wen
            affiliation:
                  name:Hebei Medical University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sui-bing Miao
            affiliation:
                  name:Hebei Medical University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Liu
            affiliation:
                  name:Hebei Medical University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bin Zheng
            affiliation:
                  name:Hebei Medical University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular and Cellular Biochemistry
      issn:
         1573-4919
         0300-8177
      volumeNumber:367
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Hebei Medical University
      address:
         name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
         type:PostalAddress
      name:Hebei Medical University
      address:
         name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
         type:PostalAddress
      name:Hebei Medical University
      address:
         name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
         type:PostalAddress
      name:Hebei Medical University
      address:
         name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
         type:PostalAddress
      name:Hebei Medical University
      address:
         name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hui-jing Shi
      affiliation:
            name:Hebei Medical University
            address:
               name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
               type:PostalAddress
            type:Organization
      name:Jin-kun Wen
      affiliation:
            name:Hebei Medical University
            address:
               name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
               type:PostalAddress
            type:Organization
      name:Sui-bing Miao
      affiliation:
            name:Hebei Medical University
            address:
               name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
               type:PostalAddress
            type:Organization
      name:Yan Liu
      affiliation:
            name:Hebei Medical University
            address:
               name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
               type:PostalAddress
            type:Organization
      name:Bin Zheng
      affiliation:
            name:Hebei Medical University
            address:
               name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
      name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
      name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
      name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
      name:Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(106)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.26s.

LINK . SPRINGER . COM {}