We are analyzing https://link.springer.com/article/10.1007/s10911-008-9084-6.

Title:
The ADAM17–amphiregulin–EGFR Axis in Mammary Development and Cancer | Journal of Mammary Gland Biology and Neoplasia
Description:
In order to fulfill its function of producing and delivering sufficient milk to newborn mammalian offspring, the mammary gland first has to form an extensive ductal network. As in all phases of mammary development, hormonal cues elicit local intra- and inter-cellular signaling cascades that regulate ductal growth and differentiation. Among other things, ductal development requires the epidermal growth factor receptor (EGFR), its ligand amphiregulin (AREG), and the transmembrane metalloproteinase ADAM17, which can cleave and release AREG from the cell surface so that it may interact with its receptor. Tissue recombination and transplantation studies demonstrate that EGFR phosphorylation and ductal development proceed only when ADAM17 and AREG are expressed on mammary epithelial cells and EGFR is present on stromal cells, and that local administration of soluble AREG can rescue the development of ADAM17-deficient transplants. Thus proper mammary morphogenesis requires the ADAM17-mediated release of AREG from ductal epithelial cells, the subsequent activation of EGFR on stromal cells, and EGFR-dependent stromal responses that in return elicit a new set of epithelial responses, all culminating in the formation of a fully functional ductal tree. This, however, raises new issues concerning what may act upstream, downstream or in parallel with the ADAM17–AREG–EGFR axis, how it may become hijacked or corrupted during the onset and evolution of cancer, and how such ill effects may be confronted.
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Keywords {🔍}

google, scholar, cas, pubmed, article, mammary, growth, gland, factor, receptor, development, cell, cancer, biol, epidermal, morphogenesis, breast, epithelial, mice, ductal, amphiregulin, cells, branching, mouse, tumor, res, expression, egfr, proliferation, estrogen, necrosis, activation, werb, dev, sci, signaling, adam, egf, human, proc, natl, acad, erbb, chem, sternlicht, sunnarborg, metalloproteinase, stromal, enzyme, lee,

Topics {✒️}

stromal–epithelial interactions regulating mt1-mmp-mediated activation month download article/chapter estrogen receptor-alpha knockout tnf alpha-deficient mice mouse strain-specific patterns epidermal growth factor strain-dependent epithelial defects inter-cellular signaling cascades epithelial growth factor egfr-dependent stromal responses egfr signalling protein-coupled receptors related subjects full article pdf adam17–amphiregulin–egfr axis mammary epithelial cells mammary gland growth lung branching morphogenesis ductal epithelial cells cultured mammary gland adam17–areg–egfr axis tgf alpha gene regulate ductal growth mammary branching morphogenesis lung bud morphogenesis human breast cancer mammary gland morphogenesis mammary end bud matrix metalloproteinase expression mouse egf receptor transgenic mice reveals egf receptor ligands jackson-fisher privacy choices/manage cookies transmembrane metalloproteinase adam17 estrogen receptor expression fgfr2b signaling regulates mouse mammary gland estrogen receptor transcription mesenchyme-dependent morphogenesis 17 beta-estradiol dominant-negative erbb2 cell growth differ human mammary fibroblasts persistent parity-induced remodeling epithelial tissues mammary gland biology embryonic mammary gland rodent mammary gland

Questions {❓}

Do different branching epithelia use a conserved developmental mechanism?

Schema {🗺️}

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