We are analyzing https://link.springer.com/article/10.1007/s10911-007-9050-8.

Title:
Modeling Metastatic Breast Cancer in Mice | Journal of Mammary Gland Biology and Neoplasia
Description:
Metastatic disease is the major cause of death in breast cancer patients. Patients presenting with metastases cannot be cured, and as a consequence, treatment is palliative and focuses on prolonging survival and maintaining quality of life. Numerous mouse models have been generated in which human breast cancer development and metastasis have been studied, ranging from spontaneous and carcinogen-induced models to transplantation models and genetically engineered mouse models. Here, we summarize past progress and highlight present developments in modeling breast cancer invasion and metastasis in genetically modified mice, and the impact it may have on the development of innovative anticancer therapies.
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Keywords {🔍}

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Topics {✒️}

e-cadherin-mediated cell–cell adhesion ovine beta-lactoglobulin gene metastasis-specific expression profiles elevated sdf-1/cxcl12 secretion involve ‘double-layered’ systems presumptive erα-positive tumors mammary gland-specific transgenesis human ha-ras oncogene antigen-induced mammary cancer node-negative breast cancer article download pdf maintain sdf1-mediated signaling estrogen receptor alpha-positive hepatocyte growth factor cell type-specific requirements calcium-binding protein s100a4 hormone receptor-positive disease mammary gland-specific expression linked c-erba oncogene site-specific recombination systems gene-expression profiles mammary epithelium-specific expression urokinase-type plasminogen activator mammary gland-specific overexpression human age-related cancers resulting pro-apoptotic signals cxcr4-positive tumor cells suggesting ligand-independent functions clear biological differences parental mda-mb-231 cells activated c-neu oncogene met-driven genetic programme mmtv-pymt mouse model early-stage breast cancer egf family-type rtk brca1/trp53 mouse model mmtv-wnt bitransgenic mice jos jonkers polyoma middle t-antigen mda-mb-231 cells appears mmtv-pymt mouse resulted tumor-promoting cell type rcas virus carrying erbb2-independent tumors recurred express wild type beta-catenin activation mmtv-pymt mice resulted 20 year recurrence-free survival receptor tyrosine kinase privacy choices/manage cookies

Questions {❓}

But how alike are mice and men?
State of the Art Modelling of the Breast Cancer Metastatic Microenvironment: Where Are We?

Schema {🗺️}

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         headline:Modeling Metastatic Breast Cancer in Mice
         description:Metastatic disease is the major cause of death in breast cancer patients. Patients presenting with metastases cannot be cured, and as a consequence, treatment is palliative and focuses on prolonging survival and maintaining quality of life. Numerous mouse models have been generated in which human breast cancer development and metastasis have been studied, ranging from spontaneous and carcinogen-induced models to transplantation models and genetically engineered mouse models. Here, we summarize past progress and highlight present developments in modeling breast cancer invasion and metastasis in genetically modified mice, and the impact it may have on the development of innovative anticancer therapies.
         datePublished:2007-06-21T00:00:00Z
         dateModified:2007-06-21T00:00:00Z
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            Mammary gland
            Transgenic
            Oncology
            Cancer Research
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      headline:Modeling Metastatic Breast Cancer in Mice
      description:Metastatic disease is the major cause of death in breast cancer patients. Patients presenting with metastases cannot be cured, and as a consequence, treatment is palliative and focuses on prolonging survival and maintaining quality of life. Numerous mouse models have been generated in which human breast cancer development and metastasis have been studied, ranging from spontaneous and carcinogen-induced models to transplantation models and genetically engineered mouse models. Here, we summarize past progress and highlight present developments in modeling breast cancer invasion and metastasis in genetically modified mice, and the impact it may have on the development of innovative anticancer therapies.
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         Transgenic
         Oncology
         Cancer Research
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