We are analyzing https://link.springer.com/article/10.1007/s10875-024-01662-4.

Title:
Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease | Journal of Clinical Immunology
Description:
Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life. Current clinical practice often involves thymus resection during cardiac surgery, detrimentally affecting T-cell immunity. However, epidemiological data indicate that CHD patients face an elevated risk for infections and immune-mediated diseases, independent of thymectomy. Hence, we examined whether the cardiac defect impacts thymus function in individuals with CHD. We investigated thymocyte development in 58 infants categorized by CHD complexity. To assess the relationship between CHD complexity and thymic function, we analyzed T-cell development, thymic output, and biomarkers linked to cardiac defects, stress, or inflammation. Patients with highly complex CHD exhibit thymic atrophy, resulting in low frequencies of recent thymic emigrants in peripheral blood, even prior to thymectomy. Elevated plasma cortisol levels were detected in all CHD patients, while high NT-proBNP and IL-6 levels were associated with thymic atrophy. Our findings reveal an association between complex CHD and thymic atrophy, resulting in reduced thymic output. Consequently, thymus preservation during cardiovascular surgery could significantly enhance immune function and the long-term health of CHD patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

chd, google, scholar, thymic, patients, heart, pubmed, levels, disease, thymus, data, congenital, children, analysis, frequencies, thymocytes, study, cyanotic, fig, development, cas, cells, ntprobnp, samples, tcell, thymocyte, cortisol, atrophy, complex, cell, acyanotic, immunol, defects, performed, umap, cardiac, test, clin, rte, function, defect, high, groups, clone, immune, central, surgery, blood, plasma, trisomy,

Topics {✒️}

cd45hi double-positive cd4+cd8+ partner site hamburg/kiel/lübeck hypoxia-inducible factor 1-alpha medical center hamburg-eppendorf regulates t-cell differentiation early t-cell compartment transforming growth factor-β full size image anti-cd69 percp-cy5 cas google scholar exacerbate t-cell lymphopenia t-cell development scheme compromised t-cell development biomarker-specific antibodies tagged peripheral t-cell compartment il-6-dependent spontaneous proliferation t-lineage-committed cells sarah-jolan bremer facilitate lymphopenia-induced proliferation laryngo-tracheo-esophageal abnormalities reduced t-cell production gittenberger-de groot ac anti-cd31 apc-cy7 severe combined immunodeficiency t-lineage-committed tga t-cell development occurs goat anti-mouse igg rainer kozlik-feldmann anti-cd4 pe-dazzle594 anti-cd28 pe-cy7 anti-cd45ra pe-dazzle594 full-term newborn infants genome-wide association study article download pdf analyzed t-cell development colitogenic il-17-producing cd8+ low nt-probnp levels high nt-probnp levels long-term clinical effects population-based case-control study inter-sample acquisition variability double-positive thymocytes nonlinear dimensionality-reduction technique enzyme-linked immunosorbent assay sp-ii thymocyte populations elevated nt-probnp levels showing thymocyte signatures full access infection-induced thymic atrophy hif-1α expression contributes

Questions {❓}

Altered thymic activity in early life: how does it affect the immune system in young adults?
Immunity and inflammation: the neglected key players in congenital heart disease?
Immunity and inflammation: the neglected key players in congenital heart disease?
Neonatal thymectomy in children—accelerating the immunologic clock?

Schema {🗺️}

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         description:Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life. Current clinical practice often involves thymus resection during cardiac surgery, detrimentally affecting T-cell immunity. However, epidemiological data indicate that CHD patients face an elevated risk for infections and immune-mediated diseases, independent of thymectomy. Hence, we examined whether the cardiac defect impacts thymus function in individuals with CHD. We investigated thymocyte development in 58 infants categorized by CHD complexity. To assess the relationship between CHD complexity and thymic function, we analyzed T-cell development, thymic output, and biomarkers linked to cardiac defects, stress, or inflammation. Patients with highly complex CHD exhibit thymic atrophy, resulting in low frequencies of recent thymic emigrants in peripheral blood, even prior to thymectomy. Elevated plasma cortisol levels were detected in all CHD patients, while high NT-proBNP and IL-6 levels were associated with thymic atrophy. Our findings reveal an association between complex CHD and thymic atrophy, resulting in reduced thymic output. Consequently, thymus preservation during cardiovascular surgery could significantly enhance immune function and the long-term health of CHD patients.
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            Infectious Diseases
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            Medical Microbiology
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      headline:Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease
      description:Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life. Current clinical practice often involves thymus resection during cardiac surgery, detrimentally affecting T-cell immunity. However, epidemiological data indicate that CHD patients face an elevated risk for infections and immune-mediated diseases, independent of thymectomy. Hence, we examined whether the cardiac defect impacts thymus function in individuals with CHD. We investigated thymocyte development in 58 infants categorized by CHD complexity. To assess the relationship between CHD complexity and thymic function, we analyzed T-cell development, thymic output, and biomarkers linked to cardiac defects, stress, or inflammation. Patients with highly complex CHD exhibit thymic atrophy, resulting in low frequencies of recent thymic emigrants in peripheral blood, even prior to thymectomy. Elevated plasma cortisol levels were detected in all CHD patients, while high NT-proBNP and IL-6 levels were associated with thymic atrophy. Our findings reveal an association between complex CHD and thymic atrophy, resulting in reduced thymic output. Consequently, thymus preservation during cardiovascular surgery could significantly enhance immune function and the long-term health of CHD patients.
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      dateModified:2024-02-23T00:00:00Z
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         Congenital heart disease (CHD)
         Thymus
         T-cell development
         Thymic atrophy
         Recent thymic emigrants (RTE)
         Immunology
         Infectious Diseases
         Internal Medicine
         Medical Microbiology
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                     name:Congenital and Pediatric Heart Surgery, Children’s Heart Clinic, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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