We are analyzing https://link.springer.com/article/10.1007/s10875-014-0106-4.

Title:
Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis | Journal of Clinical Immunology
Description:
Purpose Activating germline mutations in CARD11 have recently been linked to a rare genetic disorder associated with congenital B cell lymphocytosis. We describe a patient with a similar clinical phenotype who had a de novo germline G123D CARD11 mutation. Methods Whole exome sequencing was performed on DNA from the patient and his biological parents. Laboratory studies examined characteristics of the patient’s B and T lymphocytes. A CARD11 cDNA containing the mutation was transfected into a lymphocyte cell line to gain an understanding of its function. RNA sequencing was performed on samples from the patient and from patients with alternate germline CARD11 mutations and differential gene expression analysis was performed. Results The patient had a decade-long history of severe polyclonal B lymphocytosis in the 20,000–90,000 lymphocytes/mm3 range, which was markedly exacerbated by EBV infection and splenectomy at different times. He had a heterozygous germline CARD11 mutation causing a G123D amino acid substitution, which was demonstrated to induce NF-κB activation in unstimulated lymphocytes. In contrast to previous patients with CARD11 mutations, this patient’s B cells exhibited higher expression of several cell cycle progression genes, as well as enhanced proliferation and improved survival following B cell receptor stimulation. Conclusions This is the third reported germline and first de novo CARD11 mutation shown to cause congenital B cell lymphocytosis. The mutation was associated with a dramatically greater lymphocytosis than in previously described cases, disproportionate to the level of constitutive NF-κB activation. However, comparative review of the patient’s clinical history, combined with additional genomic and functional analyses, underscore other important variables that may affect pathophysiology or regulate mutant CARD11 function in B cell proliferation and disease. We now refer to these patients as having BENTA disease (B cell Expansion with NF-κB and T cell Anergy).
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Telecommunications
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cell, cas, card, central, germline, mutation, mutations, lymphocytosis, patient, national, usa, research, congenital, andrew, snow, gene, bcell, lymphoma, immunol, clinical, jeffrey, patients, human, biol, health, university, privacy, cookies, content, journal, severe, stinson, expression, proliferation, disease, access, med, nature, cyclin, allergy, institute, bethesda, function, information, publish, search,

Topics {✒️}

ikappab-nf-kappab signaling module month download article/chapter constitutive nf-κb activation epstein-barr virus induce nf-κb activation cd40 signaling-mediated induction b-cell lymphoproliferative disorders pkc-responsive inhibitory domain death receptor-induced apoptosis benta disease rap1-binding protein rapl sivasish sindiri anti-ig antibodies coupled antibody-secreting plasma cells cell cycle-regulated expression b-cell expansion card11 germline mutation germline card11 mutation germline card11 mutations hiv-infected viremic individuals lela kardava & susan moir oncogenic card11 mutations snow contributed equally cell receptor stimulation full article pdf extensive antigen-induced hematopoietic cell cycle author information authors cell lymphocytosis explained nf-κb human diffuse large human bcl6 gene nuclear factor kappa da silva ys tumor suppressor gene privacy choices/manage cookies clinical immunology aims similar clinical phenotype van der burg mol cell biol selective gene activation bcl-3-binding protein lymphocyte cell line cell lymphoma van dongen jj dramatically greater lymphocytosis protein kinase pkr il-21 induces differentiation severe combined immunodeficiency t-cell anergy

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis
         description:Activating germline mutations in CARD11 have recently been linked to a rare genetic disorder associated with congenital B cell lymphocytosis. We describe a patient with a similar clinical phenotype who had a de novo germline G123D CARD11 mutation. Whole exome sequencing was performed on DNA from the patient and his biological parents. Laboratory studies examined characteristics of the patient’s B and T lymphocytes. A CARD11 cDNA containing the mutation was transfected into a lymphocyte cell line to gain an understanding of its function. RNA sequencing was performed on samples from the patient and from patients with alternate germline CARD11 mutations and differential gene expression analysis was performed. The patient had a decade-long history of severe polyclonal B lymphocytosis in the 20,000–90,000 lymphocytes/mm3 range, which was markedly exacerbated by EBV infection and splenectomy at different times. He had a heterozygous germline CARD11 mutation causing a G123D amino acid substitution, which was demonstrated to induce NF-κB activation in unstimulated lymphocytes. In contrast to previous patients with CARD11 mutations, this patient’s B cells exhibited higher expression of several cell cycle progression genes, as well as enhanced proliferation and improved survival following B cell receptor stimulation. This is the third reported germline and first de novo CARD11 mutation shown to cause congenital B cell lymphocytosis. The mutation was associated with a dramatically greater lymphocytosis than in previously described cases, disproportionate to the level of constitutive NF-κB activation. However, comparative review of the patient’s clinical history, combined with additional genomic and functional analyses, underscore other important variables that may affect pathophysiology or regulate mutant CARD11 function in B cell proliferation and disease. We now refer to these patients as having BENTA disease (B cell Expansion with NF-κB and T cell Anergy).
         datePublished:2014-10-29T00:00:00Z
         dateModified:2014-10-29T00:00:00Z
         pageStart:32
         pageEnd:46
         sameAs:https://doi.org/10.1007/s10875-014-0106-4
         keywords:
            CARD11
            B-cell lymphocytosis
            congenital
            NF-κB
            BENTA
            Immunology
            Infectious Diseases
            Internal Medicine
            Medical Microbiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig6_HTML.gif
         isPartOf:
            name:Journal of Clinical Immunology
            issn:
               1573-2592
               0271-9142
            volumeNumber:35
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Andrew S. Brohl
               affiliation:
                     name:National Cancer Institute, National Institutes of Health
                     address:
                        name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jeffrey R. Stinson
               affiliation:
                     name:Uniformed Services University of the Health Sciences
                     address:
                        name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Helen C. Su
               affiliation:
                     name:National Institute of Allergy and Infectious Disease, National Institutes of Health
                     address:
                        name:Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Badgett
               affiliation:
                     name:University of Kentucky
                     address:
                        name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chester D. Jennings
               affiliation:
                     name:University of Kentucky
                     address:
                        name:Department of Pathology, College of Medicine, University of Kentucky, Lexington, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gauthaman Sukumar
               affiliation:
                     name:Uniformed Services University of the Health Sciences
                     address:
                        name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sivasish Sindiri
               affiliation:
                     name:National Cancer Institute, National Institutes of Health
                     address:
                        name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei Wang
               affiliation:
                     name:National Institute of Allergy and Infectious Diseases, NIH
                     address:
                        name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lela Kardava
               affiliation:
                     name:National Institute of Allergy and Infectious Diseases, NIH
                     address:
                        name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Susan Moir
               affiliation:
                     name:National Institute of Allergy and Infectious Diseases, NIH
                     address:
                        name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Clifton L. Dalgard
               affiliation:
                     name:Uniformed Services University of the Health Sciences
                     address:
                        name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jeffrey A. Moscow
               affiliation:
                     name:University of Kentucky
                     address:
                        name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Javed Khan
               affiliation:
                     name:National Cancer Institute, National Institutes of Health
                     address:
                        name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Andrew L. Snow
               affiliation:
                     name:Uniformed Services University of the Health Sciences
                     address:
                        name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis
      description:Activating germline mutations in CARD11 have recently been linked to a rare genetic disorder associated with congenital B cell lymphocytosis. We describe a patient with a similar clinical phenotype who had a de novo germline G123D CARD11 mutation. Whole exome sequencing was performed on DNA from the patient and his biological parents. Laboratory studies examined characteristics of the patient’s B and T lymphocytes. A CARD11 cDNA containing the mutation was transfected into a lymphocyte cell line to gain an understanding of its function. RNA sequencing was performed on samples from the patient and from patients with alternate germline CARD11 mutations and differential gene expression analysis was performed. The patient had a decade-long history of severe polyclonal B lymphocytosis in the 20,000–90,000 lymphocytes/mm3 range, which was markedly exacerbated by EBV infection and splenectomy at different times. He had a heterozygous germline CARD11 mutation causing a G123D amino acid substitution, which was demonstrated to induce NF-κB activation in unstimulated lymphocytes. In contrast to previous patients with CARD11 mutations, this patient’s B cells exhibited higher expression of several cell cycle progression genes, as well as enhanced proliferation and improved survival following B cell receptor stimulation. This is the third reported germline and first de novo CARD11 mutation shown to cause congenital B cell lymphocytosis. The mutation was associated with a dramatically greater lymphocytosis than in previously described cases, disproportionate to the level of constitutive NF-κB activation. However, comparative review of the patient’s clinical history, combined with additional genomic and functional analyses, underscore other important variables that may affect pathophysiology or regulate mutant CARD11 function in B cell proliferation and disease. We now refer to these patients as having BENTA disease (B cell Expansion with NF-κB and T cell Anergy).
      datePublished:2014-10-29T00:00:00Z
      dateModified:2014-10-29T00:00:00Z
      pageStart:32
      pageEnd:46
      sameAs:https://doi.org/10.1007/s10875-014-0106-4
      keywords:
         CARD11
         B-cell lymphocytosis
         congenital
         NF-κB
         BENTA
         Immunology
         Infectious Diseases
         Internal Medicine
         Medical Microbiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-014-0106-4/MediaObjects/10875_2014_106_Fig6_HTML.gif
      isPartOf:
         name:Journal of Clinical Immunology
         issn:
            1573-2592
            0271-9142
         volumeNumber:35
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Andrew S. Brohl
            affiliation:
                  name:National Cancer Institute, National Institutes of Health
                  address:
                     name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeffrey R. Stinson
            affiliation:
                  name:Uniformed Services University of the Health Sciences
                  address:
                     name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Helen C. Su
            affiliation:
                  name:National Institute of Allergy and Infectious Disease, National Institutes of Health
                  address:
                     name:Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Badgett
            affiliation:
                  name:University of Kentucky
                  address:
                     name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chester D. Jennings
            affiliation:
                  name:University of Kentucky
                  address:
                     name:Department of Pathology, College of Medicine, University of Kentucky, Lexington, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gauthaman Sukumar
            affiliation:
                  name:Uniformed Services University of the Health Sciences
                  address:
                     name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sivasish Sindiri
            affiliation:
                  name:National Cancer Institute, National Institutes of Health
                  address:
                     name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Wang
            affiliation:
                  name:National Institute of Allergy and Infectious Diseases, NIH
                  address:
                     name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lela Kardava
            affiliation:
                  name:National Institute of Allergy and Infectious Diseases, NIH
                  address:
                     name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susan Moir
            affiliation:
                  name:National Institute of Allergy and Infectious Diseases, NIH
                  address:
                     name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Clifton L. Dalgard
            affiliation:
                  name:Uniformed Services University of the Health Sciences
                  address:
                     name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeffrey A. Moscow
            affiliation:
                  name:University of Kentucky
                  address:
                     name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Javed Khan
            affiliation:
                  name:National Cancer Institute, National Institutes of Health
                  address:
                     name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Andrew L. Snow
            affiliation:
                  name:Uniformed Services University of the Health Sciences
                  address:
                     name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Clinical Immunology
      issn:
         1573-2592
         0271-9142
      volumeNumber:35
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Cancer Institute, National Institutes of Health
      address:
         name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:Uniformed Services University of the Health Sciences
      address:
         name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
         type:PostalAddress
      name:National Institute of Allergy and Infectious Disease, National Institutes of Health
      address:
         name:Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:University of Kentucky
      address:
         name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
         type:PostalAddress
      name:University of Kentucky
      address:
         name:Department of Pathology, College of Medicine, University of Kentucky, Lexington, USA
         type:PostalAddress
      name:Uniformed Services University of the Health Sciences
      address:
         name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
         type:PostalAddress
      name:National Cancer Institute, National Institutes of Health
      address:
         name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institute of Allergy and Infectious Diseases, NIH
      address:
         name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
         type:PostalAddress
      name:National Institute of Allergy and Infectious Diseases, NIH
      address:
         name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
         type:PostalAddress
      name:National Institute of Allergy and Infectious Diseases, NIH
      address:
         name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
         type:PostalAddress
      name:Uniformed Services University of the Health Sciences
      address:
         name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
         type:PostalAddress
      name:University of Kentucky
      address:
         name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
         type:PostalAddress
      name:National Cancer Institute, National Institutes of Health
      address:
         name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:Uniformed Services University of the Health Sciences
      address:
         name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Andrew S. Brohl
      affiliation:
            name:National Cancer Institute, National Institutes of Health
            address:
               name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Jeffrey R. Stinson
      affiliation:
            name:Uniformed Services University of the Health Sciences
            address:
               name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Helen C. Su
      affiliation:
            name:National Institute of Allergy and Infectious Disease, National Institutes of Health
            address:
               name:Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Thomas Badgett
      affiliation:
            name:University of Kentucky
            address:
               name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
               type:PostalAddress
            type:Organization
      name:Chester D. Jennings
      affiliation:
            name:University of Kentucky
            address:
               name:Department of Pathology, College of Medicine, University of Kentucky, Lexington, USA
               type:PostalAddress
            type:Organization
      name:Gauthaman Sukumar
      affiliation:
            name:Uniformed Services University of the Health Sciences
            address:
               name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Sivasish Sindiri
      affiliation:
            name:National Cancer Institute, National Institutes of Health
            address:
               name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Wei Wang
      affiliation:
            name:National Institute of Allergy and Infectious Diseases, NIH
            address:
               name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Lela Kardava
      affiliation:
            name:National Institute of Allergy and Infectious Diseases, NIH
            address:
               name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Susan Moir
      affiliation:
            name:National Institute of Allergy and Infectious Diseases, NIH
            address:
               name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Clifton L. Dalgard
      affiliation:
            name:Uniformed Services University of the Health Sciences
            address:
               name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Jeffrey A. Moscow
      affiliation:
            name:University of Kentucky
            address:
               name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
               type:PostalAddress
            type:Organization
      name:Javed Khan
      affiliation:
            name:National Cancer Institute, National Institutes of Health
            address:
               name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Andrew L. Snow
      affiliation:
            name:Uniformed Services University of the Health Sciences
            address:
               name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
      name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
      name:Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, USA
      name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
      name:Department of Pathology, College of Medicine, University of Kentucky, Lexington, USA
      name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
      name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
      name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
      name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
      name:Immunopathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA
      name:Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, USA
      name:Department of Pediatrics and Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, USA
      name:Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA
      name:Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(176)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.01s.

LINK . SPRINGER . COM {}