We are analyzing https://link.springer.com/article/10.1007/s10875-007-9104-0.

Title:
Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus | Journal of Clinical Immunology
Description:
There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.
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Keywords {🔍}

lupus, article, google, scholar, systemic, erythematosus, pubmed, cas, patients, activity, sle, disease, arthritis, immunol, rheum, biomarkers, clin, cytokine, levels, interleukin, cytokines, serum, access, production, exp, lee, kim, privacy, cookies, content, journal, park, elevated, rheumatol, data, publish, search, suh, role, active, correlation, open, cell, cells, criteria, information, log, research, clinical, chun,

Topics {✒️}

hae-sim park & chang-hee suh chang-hee suh month download article/chapter anti-double-stranded dna full article pdf related subjects privacy choices/manage cookies systemic lupus erythematosus serum interleukin-10 level clinical immunology aims article chun ja-young jeon young-min ye park yb european economic area jeong-moon yun erythrocyte sedimentation rate c-reactive protein escalate immunosuppressive therapy liang mh ter borg ej ajou university school serum il-6 level serum il-10 level conditions privacy policy article journal check access instant access hyoun-ah kim seung-hyun kim sarzi-puttini pc jae-wook chung sle activity index article log accepting optional cookies serum il-2 levels present study ifn-γ levels journal finder publish th2-derived cytokines revealed positive correlation author information authors th1/th2 paradigm th1/th2 balance article cite park hc cell growth factor il-10 suppresses production active sle patients rheumatology

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         description:There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.
         datePublished:2007-06-21T00:00:00Z
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      description:There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.
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