We are analyzing https://link.springer.com/article/10.1007/s10856-015-5474-7.

Title:
Silver-containing antimicrobial membrane based on chitosan-TPP hydrogel for the treatment of wounds | Journal of Materials Science: Materials in Medicine
Description:
Treatment of non-healing wounds represents hitherto a severe dilemma because of their failure to heal caused by repeated tissue insults, bacteria contamination and altered physiological condition. This leads to face huge costs for the healthcare worldwide. To this end, the development of innovative biomaterials capable of preventing bacterial infection, of draining exudates and of favoring wound healing is very challenging. In this study, we exploit a novel technique based on the slow diffusion of tripolyphosphate for the preparation of macroscopic chitosan hydrogels to obtain soft pliable membranes which include antimicrobial silver nanoparticles (AgNPs) stabilized by a lactose-modified chitosan (Chitlac). UV–Vis and TEM analyses demonstrated the time stability and the uniform distribution of AgNPs in the gelling mixture, while swelling studies indicated the hydrophilic behavior of membrane. A thorough investigation on bactericidal properties of the material pointed out the synergistic activity of chitosan and AgNPs to reduce the growth of S. aureus, E. coli, S. epidermidis, P. aeruginosa strains and to break apart mature biofilms. Finally, biocompatibility assays on keratinocytes and fibroblasts did not prove any harmful effects on the viability of cells. This novel technique enables the production of bioactive membranes with great potential for the treatment of non-healing wounds.
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Keywords {🔍}

article, google, scholar, silver, wound, nanoparticles, chitosan, antimicrobial, travan, mater, marsich, donati, wounds, tissue, healing, content, materials, borgogna, properties, sci, privacy, cookies, journal, based, treatment, engineering, sacco, paoletti, biomaterials, activity, chronic, med, biomacromolecules, publish, research, search, hydrogel, development, study, preparation, hydrogels, lactosemodified, chitlac, access, review, int, synthesis, trieste, data, information,

Topics {✒️}

month download article/chapter amino-silanized glass surface porous fiber-reinforced composites peptide-based wound gel chitin/nanosilver composite scaffolds project-supporting human assets homogeneous chitosan-tripolyphosphate hydrogels honey-alginate fibrous matrix cell substrates access article google scholar cell substrates published privacy choices/manage cookies related subjects silver-polysaccharide coatings chronic wound infection chitosan-tpp hydrogel full article pdf wound healing based favoring wound healing wound healing–aiming polysaccharide-based networks macroscopic chitosan hydrogels silver nanoparticles loaded ultrashort peptide hydrogels wound healing dressings innovative biomaterials capable wound repair regen wound dressing applications tissue engineering constructs lactose-modified chitosan electrospun chitosan nanofibers foster tissue healing alginate membranes loaded stable silver nanoparticles silver nanoparticles anchored european economic area repeated tissue insults altered physiological condition face huge costs tem analyses demonstrated drug delivery systems perfect skin regeneration real topical bullets rising microbial challenges atmospheric pressure plasmas sudheesh kumar pt nano-composite scaffolds tuning supramolecular structuring nonstoichiometric soluble complexes pig articular chondrocyte

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