We are analyzing https://link.springer.com/article/10.1007/s10856-013-4923-4.

Title:
Nano-composite scaffolds for bone tissue engineering containing silver nanoparticles: preparation, characterization and biological properties | Journal of Materials Science: Materials in Medicine
Description:
In this study nano-composite scaffolds to be used as bone grafts have been endowed with antibacterial properties owing to the presence of silver nanoparticles. The alginate/hydroxyapatite composite scaffolds were prepared by internal gelation followed by a freeze-drying procedure to obtain a porous structure. The nanoparticles were prepared in presence of a lactose modified-chitosan and this colloidal solution was adsorbed on the scaffolds by exploiting electrostatic interactions. The adsorption and release of the silver from the composite scaffold was measured by ICP-AES and spectrofluorimetry measurements. Micro-computed tomography analysis of the scaffolds showed a homogeneous porous structure with average pore sizes of 341.5 μm and porosity of 80 %. In vitro biological tests (MTS and killing kinetics assays) demonstrated that silver does not affect the ability of the scaffolds to promote osteoblasts proliferation and that at the same time it exerts a strong bactericidal effect against both Gram+ and Gram− bacterial strains. Overall, the combined results indicate that these biocompatible antimicrobial scaffolds possess ideal characteristics for tissue engineering applications.
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Keywords {🔍}

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Topics {✒️}

chitosan/nano-hydroxyapatite/nano-silver month download article/chapter alginate/hydroxyapatite composite scaffolds ivan donati & sergio paoletti average pore sizes comparative 18f-fdg pet eu-fp6 project “newbone” alginate/hydroxyapatite biocomposite study nano-composite scaffolds reducing implant-related infections micro-computed tomography analysis bio-composite scaffold nano-composite scaffolds bone cell materials full article pdf privacy choices/manage cookies pore morphology effects lactose modified-chitosan lactose-modified chitosan situ grown hydroxyapatite composite scaffold bone tissue engineering related subjects chitosan-mediated synthesis staphylococcus implant infections peri-implant tissues bone joint surg normal bone healing antimicrobial acrylic materials fibrovascular tissue growth european economic area freeze-drying procedure exploiting electrostatic interactions killing kinetics assays strong bactericidal effect chem soc rev total knee arthroplasty size scale garza-trevino en broad-spectrum bactericidal biomed mater res orthopedic biofilm infections pig articular chondrocyte threshold selection method gray-level histograms patrick cw jr reactive oxygen species piazza dell’ospitale 1 silver nanocomposites biomedical applications

Questions {❓}

Nanosilver toxicity: ions, nanoparticles–or both?

Schema {🗺️}

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         description:In this study nano-composite scaffolds to be used as bone grafts have been endowed with antibacterial properties owing to the presence of silver nanoparticles. The alginate/hydroxyapatite composite scaffolds were prepared by internal gelation followed by a freeze-drying procedure to obtain a porous structure. The nanoparticles were prepared in presence of a lactose modified-chitosan and this colloidal solution was adsorbed on the scaffolds by exploiting electrostatic interactions. The adsorption and release of the silver from the composite scaffold was measured by ICP-AES and spectrofluorimetry measurements. Micro-computed tomography analysis of the scaffolds showed a homogeneous porous structure with average pore sizes of 341.5 μm and porosity of 80 %. In vitro biological tests (MTS and killing kinetics assays) demonstrated that silver does not affect the ability of the scaffolds to promote osteoblasts proliferation and that at the same time it exerts a strong bactericidal effect against both Gram+ and Gram− bacterial strains. Overall, the combined results indicate that these biocompatible antimicrobial scaffolds possess ideal characteristics for tissue engineering applications.
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