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Kinetic study of controlled release of VPA and DPH antiepileptic drugs using biocompatible nanostructured sol–gel TiO2 | Journal of Materials Science
Description:
Sol–gel TiO2 porous matrix was used to host valproic acid (VPA) and phenytoin (DPH), which are commonly used as antiepileptic drugs. The addition of these drugs was carried out during the synthesis in the hydrolysis stage. In vitro short term kinetic studies on drug liberation showed that almost all samples followed a first order kinetics with the exception of one sample which had a linear behavior. High resolution electron microscopy revealed the existence of nanocrystalinity in all samples, however, electron diffraction patterns showed that some were predominantly amorphous while in others suggested a greater density of nanocrystals. NMR studies demonstrated that VPA was less mobile in a more crystalline TiO2 matrix than when the TiO2 is mainly amorphous. Some features of the kinetics of drug liberation are explained in terms of the competition between nanocrystallinity and drug content. The reservoirs were implanted by means of stereotactic surgery in Wistar rats in which epilepsy was previously induced following the Kindling model of epilepsy. The efficiency of the reservoirs was follow by electroencephalography (EEGs). In vivo studies revealed that a more crystalline sample was more effective in preventing further epileptic events than samples with a higher content of VPA but predominantly amorphous.
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article, google, scholar, méxico, cas, content, drug, release, tio, lópez, access, privacy, cookies, journal, vpa, antiepileptic, drugs, studies, electron, publish, research, search, kinetic, controlled, high, resolution, microscopy, lopez, universidad, autónoma, col, data, information, log, materials, study, dph, solgel, alexanderkatz, castillo, manjarrez, gonzalez, liberation, samples, amorphous, open, discover, mater, ads, nature,
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month download article/chapter drug liberation showed x-ray runs included drug liberation crystalline tio2 matrix vitro drug release materials science aims related subjects universidad autónoma metropolitana-iztapalapa vivo studies revealed kinetic study full article pdf privacy choices/manage cookies host valproic acid check access instant access universidad autónoma metropolitana autónoma metropolitana-xochimilco chemical research center instituto superior tecnico drug content nmr studies demonstrated european economic area scope submit manuscript venier-juliennea m marco antonio vera víctor hugo lara conditions privacy policy accepting optional cookies article journal journal finder publish dph antiepileptic drugs author information authors article log tio2 article lópez article cite nmr studies 2024 polymeric nanoparticles privacy policy personal data controlled release controlled release 65 controlled release 132 lopez books a antiepileptic drugs alexander-katz optional cookies manage preferences
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datePublished:2009-08-06T00:00:00Z
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description:Sol–gel TiO2 porous matrix was used to host valproic acid (VPA) and phenytoin (DPH), which are commonly used as antiepileptic drugs. The addition of these drugs was carried out during the synthesis in the hydrolysis stage. In vitro short term kinetic studies on drug liberation showed that almost all samples followed a first order kinetics with the exception of one sample which had a linear behavior. High resolution electron microscopy revealed the existence of nanocrystalinity in all samples, however, electron diffraction patterns showed that some were predominantly amorphous while in others suggested a greater density of nanocrystals. NMR studies demonstrated that VPA was less mobile in a more crystalline TiO2 matrix than when the TiO2 is mainly amorphous. Some features of the kinetics of drug liberation are explained in terms of the competition between nanocrystallinity and drug content. The reservoirs were implanted by means of stereotactic surgery in Wistar rats in which epilepsy was previously induced following the Kindling model of epilepsy. The efficiency of the reservoirs was follow by electroencephalography (EEGs). In vivo studies revealed that a more crystalline sample was more effective in preventing further epileptic events than samples with a higher content of VPA but predominantly amorphous.
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