We are analyzing https://link.springer.com/article/10.1007/s10815-018-1268-4.

Title:
GDF-9 and BMP-15 direct the follicle symphony | Journal of Assisted Reproduction and Genetics
Description:
Understanding the physiology underlying the complex dialog between the oocyte and its surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in a synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system has been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women.
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Keywords {🔍}

pubmed, article, google, scholar, cas, reprod, growth, cells, ovarian, bmp, cell, factor, gdf, oocyte, cumulus, granulosa, differentiation, biol, bone, morphogenetic, development, central, factors, protein, human, endocrinol, mol, function, hum, mouse, oocytes, follicular, follicle, albertini, role, expression, dev, reproduction, oocytesecreted, superfamily, folliculogenesis, regulation, gilchrist, eppig, genes, ovary, sci, receptor, signalling, vitro,

Topics {✒️}

month download article/chapter transforming growth factor-beta differing oocyte-secreted factors implicated oocyte-secreted factors polycystic ovary syndrome tgf-beta superfamily signalling oocyte-secreted factors gdf-9 noncanonical smad2/smad3 signaling peri-implantation uterine signaling oocyte-somatic cell communication promotes matrix cross-linking oocyte-somatic cell interactions gonadotropin-induced follicular development tgf-beta superfamily members cumulus expansion-enabling factor oocyte-somatic cell dialog female fertility disorders full article pdf su yq oocyte-secreted factors bone morphogenetic protein-15 growth differentiation factors primary ovarian insufficiency tgf beta type tgf-beta signalling chang hm bovine ovarian follicles oocyte-secreted factor high quality oocyte oocyte-specific expression growth/differentiation factor-9 growth differentiation factor-9 privacy choices/manage cookies mottershead dg smad2/3 signaling pathways bovine cumulus cells fundamental factors implicated di pasquale oocyte-secreted heterodimer reprod biomed online age-related decline related subjects bone morphogenetic proteins low competence oocytes granulosa cells derived oocyte-produced factor improves oocyte quality mouse ovarian follicles theca-derived bmp4 signalling pathways involved

Schema {🗺️}

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