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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10787-021-00822-x.

Title:
Current jakinibs for the treatment of rheumatoid arthritis: a systematic review | Inflammopharmacology
Description:
Objective One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. Methods We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. Results All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Conclusions Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 8,280,528 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

arthritis, rheumatoid, article, google, scholar, patients, treatment, cas, jak, efficacy, methotrexate, jakinibs, safety, inhibitor, rheumatol, tanaka, peficitinib, combination, study, information, tofacitinib, baricitinib, doubleblind, placebocontrolled, genovese, wang, phase, response, tübingen, privacy, cookies, content, data, review, inhibitors, diseasemodifying, antirheumatic, clinical, results, access, protein, van, randomised, dis, takeuchi, inadequate, publish, search, systematic, bettanin,

Topics {✒️}

jak/stat signal pathway interferon-β ifn-γ janus kinase/signal transducers anti-citrullinated protein antibodies márcia inês goettert anti-carbamylated protein antibodies interferon-α ifn-β month download article/chapter alessandro menna alves biotechnology graduate program randomized placebo-controlled study meta-analysis article 14 article inflammopharmacology aims beatriz fabris bettanin low disease activity matthias gehringer academic drug discovery phase iib study small molecule therapeutics phase iii study de freitas mvc full article pdf privacy choices/manage cookies van der heijde active rheumatoid arthritis placebo-controlled trial selective jak-1 inhibitor interleukin-6 ifn-α abbreviations anti-ccp dose-ranging study phase iii randomised genovese mc van vollenhoven rf rheumatoid arthritis equivalent code availability severe rheumatoid arthritis severe rheumatoid arthritis european economic area adjusted indirect comparison related subjects gutierrez-ureña sr connective tissue diseases ms kristine schmidt article rocha university center univates conditions privacy policy bone marrow oedema accepting optional cookies fernanda majolo ethics declarations conflict

Questions {❓}

  • Are all JAK inhibitors for the treatment of rheumatoid arthritis equivalent?

Schema {🗺️}

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         headline:Current jakinibs for the treatment of rheumatoid arthritis: a systematic review
         description:One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
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      headline:Current jakinibs for the treatment of rheumatoid arthritis: a systematic review
      description:One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
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      cssSelector:.main-content

External Links {🔗}(81)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.8s.