
LINK . SPRINGER . COM {
}
Title:
Current jakinibs for the treatment of rheumatoid arthritis: a systematic review | Inflammopharmacology
Description:
Objective One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. Methods We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. Results All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Conclusions Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Health & Fitness
- Education
- Science
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 8,280,528 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We can't tell how the site generates income.
The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.
Keywords {🔍}
arthritis, rheumatoid, article, google, scholar, patients, treatment, cas, jak, efficacy, methotrexate, jakinibs, safety, inhibitor, rheumatol, tanaka, peficitinib, combination, study, information, tofacitinib, baricitinib, doubleblind, placebocontrolled, genovese, wang, phase, response, tübingen, privacy, cookies, content, data, review, inhibitors, diseasemodifying, antirheumatic, clinical, results, access, protein, van, randomised, dis, takeuchi, inadequate, publish, search, systematic, bettanin,
Topics {✒️}
jak/stat signal pathway interferon-β ifn-γ janus kinase/signal transducers anti-citrullinated protein antibodies márcia inês goettert anti-carbamylated protein antibodies interferon-α ifn-β month download article/chapter alessandro menna alves biotechnology graduate program randomized placebo-controlled study meta-analysis article 14 article inflammopharmacology aims beatriz fabris bettanin low disease activity matthias gehringer academic drug discovery phase iib study small molecule therapeutics phase iii study de freitas mvc full article pdf privacy choices/manage cookies van der heijde active rheumatoid arthritis placebo-controlled trial selective jak-1 inhibitor interleukin-6 ifn-α abbreviations anti-ccp dose-ranging study phase iii randomised genovese mc van vollenhoven rf rheumatoid arthritis equivalent code availability severe rheumatoid arthritis severe rheumatoid arthritis european economic area adjusted indirect comparison related subjects gutierrez-ureña sr connective tissue diseases ms kristine schmidt article rocha university center univates conditions privacy policy bone marrow oedema accepting optional cookies fernanda majolo ethics declarations conflict
Questions {❓}
- Are all JAK inhibitors for the treatment of rheumatoid arthritis equivalent?
Schema {🗺️}
WebPage:
mainEntity:
headline:Current jakinibs for the treatment of rheumatoid arthritis: a systematic review
description:One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
datePublished:2021-05-27T00:00:00Z
dateModified:2021-05-27T00:00:00Z
pageStart:595
pageEnd:615
sameAs:https://doi.org/10.1007/s10787-021-00822-x
keywords:
JAK inhibitors
Small molecules
Rheumatoid arthritis
Pharmacology/Toxicology
Immunology
Rheumatology
Gastroenterology
Dermatology
Allergology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_Fig2_HTML.png
isPartOf:
name:Inflammopharmacology
issn:
1568-5608
0925-4692
volumeNumber:29
type:
Periodical
PublicationVolume
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Cláudia Monfroni Rocha
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Alessandro Menna Alves
affiliation:
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Beatriz Fabris Bettanin
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Fernanda Majolo
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Matthias Gehringer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefan Laufer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Márcia Inês Goettert
url:http://orcid.org/0000-0002-3648-5033
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Universidade do Vale do Taquari, Univates
address:
name:Medical Sciences Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Current jakinibs for the treatment of rheumatoid arthritis: a systematic review
description:One-third of patients with severe rheumatoid arthritis (RA) do not achieve remission or low disease activity, or they have side effects from cDMARD and bDMARD. They will need a new treatment option such as the small molecule JAK inhibitors. In this systematic review, we evaluate the efficacy and safety data of the current jakinibs: tofacitinib, peficitinib, decernotinib, upadacitinib, baricitinib and filgotinib in patients in whom treatment with conventional or biological disease-modifying antirheumatic drugs (cDMARD and/or bDMARD) failed. We searched for randomized controlled trials comparing efficacy and safety of jakinibs for RA treatment using the Web of Science, Scopus, PubMed, and clinicaltrials.gov databases with the terms: “rheumatoid arthritis” OR “arthritis rheumatoid” OR “RA” AND “inhibitor” OR “jak inhibitor” AND “clinical trial” OR “treatment” OR “therapy”. All jakinibs achieved good results in ACR 20, 50, 70 and with CRP-DAS28 for LDA and remission, upadacitinib showed better results compared to the others. In ESR-DAS28 for remission, tofacitinib achieved the best result. Regarding the safety of all jakinibs, peficitinib, baricitinib and filgotinib did not register deaths in their studies unlike tofacitinib that presented 11 deaths. Despite all benefits of jakinibs, the use in patients with severe liver and kidney disease should be avoided. Jakinibs in monotherapy or in combination with methotrexate can be considered a viable alternative in the treatment of moderate-to-severe RA. Even after failures with combination of cDMARDS and bDMARDS, jakinibs demonstrated efficacy.
datePublished:2021-05-27T00:00:00Z
dateModified:2021-05-27T00:00:00Z
pageStart:595
pageEnd:615
sameAs:https://doi.org/10.1007/s10787-021-00822-x
keywords:
JAK inhibitors
Small molecules
Rheumatoid arthritis
Pharmacology/Toxicology
Immunology
Rheumatology
Gastroenterology
Dermatology
Allergology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_Fig2_HTML.png
isPartOf:
name:Inflammopharmacology
issn:
1568-5608
0925-4692
volumeNumber:29
type:
Periodical
PublicationVolume
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Cláudia Monfroni Rocha
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Alessandro Menna Alves
affiliation:
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Beatriz Fabris Bettanin
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Fernanda Majolo
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
type:Person
name:Matthias Gehringer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefan Laufer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Márcia Inês Goettert
url:http://orcid.org/0000-0002-3648-5033
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Universidade do Vale do Taquari, Univates
address:
name:Medical Sciences Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Inflammopharmacology
issn:
1568-5608
0925-4692
volumeNumber:29
Organization:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
name:Eberhard Karls Universität Tübingen
address:
name:Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
name:Universidade do Vale do Taquari, Univates
address:
name:Medical Sciences Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Cláudia Monfroni Rocha
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Alessandro Menna Alves
affiliation:
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Beatriz Fabris Bettanin
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:University Center Univates
address:
name:School of Dentistry, University Center Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Fernanda Majolo
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Matthias Gehringer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
name:Stefan Laufer
affiliation:
name:Eberhard Karls Universität Tübingen
address:
name:Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Eberhard Karls Universität Tübingen
address:
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
type:PostalAddress
type:Organization
name:Tübingen Center for Academic Drug Discovery (TüCAD2)
address:
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
type:PostalAddress
type:Organization
name:Márcia Inês Goettert
url:http://orcid.org/0000-0002-3648-5033
affiliation:
name:Universidade do Vale do Taquari, Univates
address:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
name:Universidade do Vale do Taquari, Univates
address:
name:Medical Sciences Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
name:School of Dentistry, University Center Univates, Lajeado, Brazil
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
name:School of Dentistry, University Center Univates, Lajeado, Brazil
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
name:Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, Tübingen, Germany
name:Cluster of Excellence iFIT (EXC 2180) ‘Image-Guided and Functionally Instructed Tumor Therapies’, Eberhard Karls Universität Tübingen, Tübingen, Germany
name:Tübingen Center for Academic Drug Discovery (TüCAD2), Tübingen, Germany
name:Cell Culture Laboratory, Biotechnology Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
name:Medical Sciences Graduate Program, Universidade do Vale do Taquari, Univates, Lajeado, Brazil
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(81)
- How much income does https://www.springernature.com/gp/authors have?
- Check the income stats for https://link.springernature.com/home/
- https://order.springer.com/public/cart income
- How much profit is https://www.editorialmanager.com/iphm making per month?
- What's the financial intake of https://orcid.org/0000-0002-3648-5033?
- Earnings of https://www.springernature.com/gp/librarians/licensing/agc/journals
- How much money does https://doi.org/10.1136%2Fannrheumdis-2015-208267 generate?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Comparing%20the%20effects%20of%20tofacitinib%2C%20methotrexate%20and%20the%20combination%2C%20on%20bone%20marrow%20oedema%2C%20synovitis%20and%20bone%20erosion%20in%20methotrexate-naive%2C%20early%20active%20rheumatoid%20arthritis%3A%20results%20of%20an%20exploratory%20randomised%20MRI%20study%20incorporating%20semiquantitative%20and%20quantitative%20techniques&journal=Ann%20Rheum%20Dis&doi=10.1136%2Fannrheumdis-2015-208267&volume=75&pages=1024-1033&publication_year=2016&author=Conaghan%2CPG&author=%C3%98stergaard%2CM&author=Bowes%2CMA&author=Wu%2CC&author=Fuerst%2CT&author=Heijde%2CD&author=Irazoque-Palazuelos%2CF&author=Soto-Raices%2CO&author=Hrycaj%2CP&author=Xie%2CZ&author=Zhang%2CR&author=Wyman%2CBT&author=Bradley%2CJD&author=Soma%2CK&author=Wilkinson%2CB?
- What's https://doi.org/10.1590%2FS0482-50042011000300002's gross income?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Consenso%20Da%20Sociedade%20Brasileira%20de%20Reumatologia%202011%20Para%20o%20Diagn%C3%B3stico%20e%20Avalia%C3%A7%C3%A3o%20Inicial%20Da%20Artrite%20Reumatoide&journal=Rev%20Bras%20Reumatol&doi=10.1590%2FS0482-50042011000300002&volume=51&pages=207-219&publication_year=2011&author=Mota%2CLMH&author=Cruz%2CBA&author=Brenol%2CCV&author=Pereira%2CIA&author=Fronza%2CLSR&author=Bertolo%2CMB&author=Freitas%2CMVC&author=Silva%2CNA&author=Louzada-Junior%2CP&author=Giorgi%2CRDN&author=Lima%2CRAC&author=Pinheiro%2CGRC make?
- How much does https://doi.org/10.1002%2Fart.39953 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Baricitinib%2C%20methotrexate%2C%20or%20combination%20in%20patients%20with%20rheumatoid%20arthritis%20and%20no%20or%20limited%20prior%20disease-modifying%20antirheumatic%20drug%20treatment&journal=Arthritis%20and%20Rheumatol&doi=10.1002%2Fart.39953&volume=69&pages=506-517&publication_year=2017&author=Fleischmann%2CR&author=Schiff%2CM&author=Heijde%2CD&author=Ramos-Remus%2CC&author=Spindler%2CA&author=Stanislav%2CM&author=Zerbini%2CCA&author=Gurbuz%2CS&author=Dickson%2CC&author=Bono%2CS&author=Schlichting%2CD&author=Beattie%2CS&author=Kuo%2CWL&author=Rooney%2CT&author=Macias%2CW&author=Takeuchi%2CT bring in each month?
- Get to know https://doi.org/10.1002%2Fart.38949's earnings
- http://scholar.google.com/scholar_lookup?&title=A%20randomized%2C%20double-blind%2C%20placebo-controlled%2C%20twelve-week%2C%20dose-ranging%20study%20of%20decernotinib%2C%20an%20oral%20selective%20JAK-3%20inhibitor%2C%20as%20monotherapy%20in%20patients%20with%20active%20rheumatoid%20arthritis&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.38949&volume=67&pages=334-343&publication_year=2015&author=Fleischmann%2CRM&author=Damjanov%2CNS&author=Kivitz%2CAJ&author=Legedza%2CA&author=Hoock%2CT&author=Kinnman%2CN's total income per month
- What's the profit of https://doi.org/10.1002%2Fart.39808?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Efficacy%20and%20safety%20of%20ABT-494%2C%20a%20selective%20JAK-1%20inhibitor%2C%20in%20a%20phase%20IIb%20study%20in%20patients%20with%20rheumatoid%20arthritis%20and%20an%20inadequate%20response%20to%20methotrexate&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.39808&volume=68&pages=2857-2866&publication_year=2016&author=Genovese%2CMC&author=Smolen%2CJS&author=Weinblatt%2CME&author=Burmester%2CGR&author=Meerwein%2CS&author=Camp%2CHS&author=Wang%2CL&author=Othman%2CAA&author=Khan%2CN&author=Pangan%2CAL&author=Jungerwirth%2CS
- Get to know what's the income of https://doi.org/10.1002%2Fart.39473
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=VX-509%20%28Decernotinib%29%2C%20an%20oral%20selective%20JAK-3%20inhibitor%2C%20in%20combination%20with%20methotrexate%20in%20patients%20with%20rheumatoid%20arthritis&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.39473&volume=68&pages=46-55&publication_year=2016&author=Genovese%2CMC&author=Vollenhoven%2CRF&author=Pacheco-Tena%2CC&author=Zhang%2CY&author=Kinnman%2CN each month?
- What's the monthly income of https://doi.org/10.1002%2Fart.40054?
- http://scholar.google.com/scholar_lookup?&title=Peficitinib%2C%20a%20JAK%20inhibitor%2C%20in%20combination%20with%20limited%20conventional%20synthetic%20disease-modifying%20antirheumatic%20drugs%20in%20the%20treatment%20of%20moderate-to-severe%20rheumatoid%20arthritis&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.40054&volume=69&pages=932-942&publication_year=2017&author=Genovese%2CMC&author=Greenwald%2CM&author=Codding%2CC&author=Zubrzycka-Sienkiewicz%2CA&author=Kivitz%2CAJ&author=Wang%2CA&author=Shay%2CK&author=Wang%2CX&author=Garg%2CJP&author=Cardiel%2CMH's financial summary
- How much money does https://doi.org/10.1001%2Fjama.2019.9055 make?
- http://scholar.google.com/scholar_lookup?&title=Effect%20of%20filgotinib%20vs%20placebo%20on%20clinical%20response%20in%20patients%20with%20moderate%20to%20severe%20rheumatoid%20arthritis%20refractory%20to%20disease-modifying%20antirheumatic%20drug%20therapy%3A%20the%20FINCH%202%20randomized%20clinical%20trial&journal=JAMA&doi=10.1001%2Fjama.2019.9055&volume=322&pages=315-325&publication_year=2019&author=Genovese%2CMC&author=Kalunian%2CK&author=Gottenberg%2CJE&author=Mozaffarian%2CN&author=Bartok%2CB&author=Matzkies%2CF&author=Gao%2CJ&author=Guo%2CY&author=Tasset%2CC&author=Sundy%2CJS&author=Vlam%2CK&author=Walker%2CD&author=Takeuchi%2CT's revenue stream
- What's the financial outcome of https://doi.org/10.1093%2Frheumatology%2Fkes367?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Novel%20small%20molecule%20therapeutics%20in%20rheumatoid%20arthritis&journal=Rheumatology%20%28oxford%29&doi=10.1093%2Frheumatology%2Fkes367&volume=52&pages=1155-1162&publication_year=2013&author=Kelly%2CV&author=Genovese%2CM?
- What's the financial intake of https://doi.org/10.1002%2Fart.39955?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Peficitinib%2C%20a%20JAK%20inhibitor%2C%20in%20the%20treatment%20of%20moderate-to-severe%20rheumatoid%20arthritis%20in%20patients%20with%20an%20inadequate%20response%20to%20methotrexate&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.39955&volume=69&pages=709-719&publication_year=2017&author=Kivitz%2CAJ&author=Gutierrez-Ure%C3%B1a%2CSR&author=Poiley%2CJ&author=Genovese%2CMC&author=Kristy%2CR&author=Shay%2CK&author=Wang%2CX&author=Garg%2CJP&author=Zubrzycka-Sienkiewicz%2CA?
- How much profit does https://doi.org/10.1177%2F1759720X18776224 generate?
- Profit of http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20the%20JAK%2FSTAT%20signal%20pathway%20in%20rheumatoid%20arthritis&journal=Ther%20Adv%20Musculoskelet%20Dis&doi=10.1177%2F1759720X18776224&volume=10&pages=117-127&publication_year=2018&author=Malemud%2CCJ
- How much does http://scholar.google.com/scholar_lookup?&title=Discovery%20of%20a%20highly%20selective%20JAK3%20inhibitor%20for%20the%20treatment%20of%20rheumatoid%20arthritis&journal=Sci%20Rep&volume=8&publication_year=2018&author=Pei%2CH&author=He%2CL&author=Shao%2CM&author=Yang%2CZ&author=Ran%2CY&author=Li%2CD&author=Zhou%2CY&author=Tang%2CM&author=Wang%2CT&author=Gong%2CY&author=Chen%2CX&author=Yang%2CS&author=Xiang%2CM&author=Chen%2CL generate monthly?
- What's the revenue for https://doi.org/10.1016%2FS0140-6736%2819%2930419-2?
- http://scholar.google.com/scholar_lookup?&title=Upadacitinib%20as%20monotherapy%20in%20patients%20with%20active%20rheumatoid%20arthritis%20and%20inadequate%20response%20to%20methotrexate%20%28SELECT-MONOTHERAPY%29%3A%20a%20randomised%2C%20placebo-controlled%2C%20double-blind%20phase%203%20study&journal=Lancet&doi=10.1016%2FS0140-6736%2819%2930419-2&volume=393&pages=2303-2311&publication_year=2019&author=Smolen%2CJS&author=Pangan%2CAL&author=Emery%2CP&author=Rigby%2CW&author=Tanaka%2CY&author=Vargas%2CJI&author=Zhang%2CY&author=Damjanov%2CN&author=Friedman%2CA&author=Othman%2CAA&author=Camp%2CHS&author=Cohen%2CS's revenue stream
- What's the profit of https://doi.org/10.1136%2Fannrheumdis-2015-208279?
- http://scholar.google.com/scholar_lookup?&title=Efficacy%20and%20safety%20of%20the%20oral%20janus%20kinase%20inhibitor%20peficitinib%20%28ASP015K%29%20monotherapy%20in%20patients%20with%20moderate%20to%20severe%20rheumatoid%20arthritis%20in%20Japan%3A%20a%2012-week%2C%20randomised%2C%20double-blind%2C%20placebo-controlled%20phase%20IIb%20study&journal=Ann%20Rheum%20Dis&doi=10.1136%2Fannrheumdis-2015-208279&volume=75&pages=1057-1064&publication_year=2016&author=Takeuchi%2CT&author=Tanaka%2CY&author=Iwasaki%2CM&author=Ishikura%2CH&author=Saeki%2CS&author=Kaneko%2CY income
- Discover the revenue of https://doi.org/10.1136%2Fannrheumdis-2019-215164
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Efficacy%20and%20safety%20of%20peficitinib%20%28ASP015K%29%20in%20patients%20with%20rheumatoid%20arthritis%20and%20an%20inadequate%20response%20to%20methotrexate%3A%20results%20of%20a%20phase%20III%20randomised%2C%20double-blind%2C%20placebo-controlled%20trial%20%28RAJ4%29%20in%20Japan&journal=Ann%20Rheum%20Dis&doi=10.1136%2Fannrheumdis-2019-215164&volume=78&pages=1305-1319&publication_year=2019&author=Takeuchi%2CT&author=Tanaka%2CY&author=Tanaka%2CS&author=Kawakami%2CA&author=Iwasaki%2CM&author=Katayama%2CK&author=Rokuda%2CM&author=Izutsu%2CH&author=Ushijima%2CS&author=Kaneko%2CY&author=Shiomi%2CT&author=Yamada%2CE&author=Heijde%2CD generate?
- How much does https://doi.org/10.3899%2Fjrheum.150613 pull in?
- What's http://scholar.google.com/scholar_lookup?&title=Efficacy%20and%20safety%20of%20baricitinib%20in%20Japanese%20patients%20with%20active%20rheumatoid%20arthritis%20receiving%20background%20methotrexate%20therapy%3A%20a%2012-week%2C%20double-blind%2C%20randomized%20placebo-controlled%20study&journal=J%20Rheumatol&doi=10.3899%2Fjrheum.150613&volume=43&pages=504-511&publication_year=2016&author=Tanaka%2CY&author=Emoto%2CK&author=Cai%2CZ&author=Aoki%2CT&author=Schlichting%2CD&author=Rooney%2CT&author=Macias%2CW's gross income?
- See how much https://doi.org/10.1136%2Fannrheumdis-2019-215163 makes per month
- How much does http://scholar.google.com/scholar_lookup?&title=Efficacy%20and%20safety%20of%20peficitinib%20%28ASP015K%29%20in%20patients%20with%20rheumatoid%20arthritis%20and%20an%20inadequate%20response%20to%20conventional%20DMARDs%3A%20a%20randomised%2C%20double-blind%2C%20placebo-controlled%20Phase%20III%20trial%20%28RAJ3%29&journal=Ann%20Rheum%20Dis&doi=10.1136%2Fannrheumdis-2019-215163&volume=78&pages=1320-1332&publication_year=2019&author=Tanaka%2CY&author=Takeuchi%2CT&author=Tanaka%2CS&author=Kawakami%2CA&author=Iwasaki%2CM&author=Song%2CYW&author=Chen%2CYH&author=Wei%2CJC&author=Lee%2CSH&author=Rokuda%2CM&author=Izutsu%2CH&author=Ushijima%2CS&author=Kaneko%2CY&author=Akazawa%2CR&author=Shiomi%2CT&author=Yamada%2CE pull in?
- What's the income generated by https://doi.org/10.5114%2Freum.2020.102006 each month?
- How much does http://scholar.google.com/scholar_lookup?&title=Baricitinib%20for%20the%20treatment%20of%20rheumatoid%20arthritis&journal=Reumatologia%20Rheumatology&doi=10.5114%2Freum.2020.102006&volume=58&pages=407-415&publication_year=2020&author=Urits%2CI&author=Israel%2CJ&author=Hakobyan%2CH&author=Yusin%2CG&author=Lassiter%2CG&author=Fackler%2CN&author=Berger%2CA&author=Kassem%2CH&author=Kaye%2CA&author=Viswanath%2CO net monthly?
- https://doi.org/10.1002%2Fart.40803's financial summary
- How much does http://scholar.google.com/scholar_lookup?&title=Tofacitinib%20in%20combination%20with%20methotrexate%20in%20patients%20with%20rheumatoid%20arthritis%3A%20clinical%20efficacy%2C%20radiographic%2C%20and%20safety%20outcomes%20from%20a%20twenty-four%E2%80%93month%2C%20phase%20III%20study&journal=Arthritis%20Rheumatol&doi=10.1002%2Fart.40803&volume=71&pages=878-891&publication_year=2019&author=Heijde%2CD&author=Strand%2CV&author=Tanaka%2CY&author=Keystone%2CE&author=Kremer%2CJ&author=Zerbini%2CCAF&author=Cardiel%2CMH&author=Cohen%2CS&author=Nash%2CP&author=Song%2CYW&author=Tegzov%C3%A1%2CD&author=Gruben%2CD&author=Wallenstein%2CG&author=Connell%2CCA&author=Fleischmann%2CR earn?
- Get to know http://scholar.google.com/scholar_lookup?&title=From%20rheumatoid%20factor%20to%20anti-citrullinated%20protein%20antibodies%20and%20anti-carbamylated%20protein%20antibodies%20for%20diagnosis%20and%20prognosis%20prediction%20in%20patients%20with%20rheumatoid%20arthritis&journal=Int%20J%20Mol%20Sci&volume=22&pages=1-18&publication_year=2021&author=Yi%2CWC&author=Yang%2CHY&author=Luo%2CSF&author=Lai%2CJH's earnings
- How much revenue does http://scholar.google.com/scholar_lookup?&title=JAK%20inhibitors%3A%20prospects%20in%20connective%20tissue%20diseases&journal=Clin%20Rev%20Allergy%20Immunol&doi=10.1007%2Fs12016-020-08786-6&volume=5&pages=334-351&publication_year=2020&author=You%2CH&author=Xu%2CD&author=Zhao%2CJ&author=Li%2CJ&author=Wang%2CQ&author=Tian%2CX&author=Li%2CM&author=Zeng%2CX bring in?
- What's the total monthly financial gain of https://citation-needed.springer.com/v2/references/10.1007/s10787-021-00822-x?format=refman&flavour=references?
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Cl%C3%A1udia%20Monfroni%20Rocha?
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Cl%C3%A1udia%20Monfroni%20Rocha%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Alessandro%20Menna%20Alves's revenue stream
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Alessandro%20Menna%20Alves%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Beatriz%20Fabris%20Bettanin rake in every month?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Beatriz%20Fabris%20Bettanin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fernanda%20Majolo?
- Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Fernanda%20Majolo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Matthias%20Gehringer each month?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Matthias%20Gehringer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Stefan%20Laufer's gross income?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Stefan%20Laufer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%C3%A1rcia%20In%C3%AAs%20Goettert have monthly?
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%C3%A1rcia%20In%C3%AAs%20Goettert%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the profit of https://static-content.springer.com/esm/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_MOESM1_ESM.docx?
- What's the revenue for https://static-content.springer.com/esm/art%3A10.1007%2Fs10787-021-00822-x/MediaObjects/10787_2021_822_MOESM2_ESM.docx?
- What is the earnings of https://s100.copyright.com/AppDispatchServlet?title=Current%20jakinibs%20for%20the%20treatment%20of%20rheumatoid%20arthritis%3A%20a%20systematic%20review&author=Cl%C3%A1udia%20Monfroni%20Rocha%20et%20al&contentID=10.1007%2Fs10787-021-00822-x©right=The%20Author%28s%29%2C%20under%20exclusive%20licence%20to%20Springer%20Nature%20Switzerland%20AG&publication=0925-4692&publicationDate=2021-05-27&publisherName=SpringerNature&orderBeanReset=true?
- What's the profit of https://crossmark.crossref.org/dialog/?doi=10.1007/s10787-021-00822-x?
- What's the financial outcome of https://citation-needed.springer.com/v2/references/10.1007/s10787-021-00822-x?format=refman&flavour=citation?
- Learn about the earnings of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral
- Learn about the earnings of https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research
- How much does https://www.springernature.com/gp/products generate monthly?
- What's the income of https://www.springernature.com/gp/librarians?
- How much profit is https://www.springernature.com/gp/societies making per month?
- Check the income stats for https://www.springernature.com/gp/partners
- What's the monthly income of https://www.springer.com/?
- How much does https://www.nature.com/ bring in each month?
- Check the income stats for https://www.biomedcentral.com/
- Profit of https://www.palgrave.com/
- Earnings of https://www.apress.com/
- How much profit does https://www.springernature.com/gp/legal/ccpa make?
- What's https://www.springernature.com/gp/info/accessibility's gross income?
- What are the earnings of https://support.springernature.com/en/support/home?
- Revenue of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations
- What's the monthly income of https://www.springernature.com/?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref