We are analyzing https://link.springer.com/article/10.1007/s10753-022-01689-y.

Title:
Resveratrol Ameliorates Deep Vein Thrombosis-Induced Inflammatory Response Through Inhibiting HIF-1α/NLRP3 Pathway | Inflammation
Description:
Deep vein thrombosis (DVT) has become a prevalent and increasingly serious problem globally and resveratrol (Res) is a natural antitoxin that inhibits arterial thrombosis. To investigate the effect of Res on DVT and further explore its mechanism, thrombosis was monitored at different time points and the pathological changes occurring in the inferior vena cava (IVC) and lung tissue were observed in Sprague–Dawley rats. The protein expression of HIF-1α and NLRP3 in the IVC and lung tissue and the concentrations of D-dimer (D2D), prothrombin fragment 1 + 2 (F1 + 2), interleukin-1β (IL-1β), caspase-1, and tissue factor (TF) in the plasma were determined. After setting different doses of Res groups and using low-molecular-weight heparin (LMWH) as a positive control to determine the effective experimental dose of Res, rats were further divided into sham, DVT, HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. The above indicators were tested repeatedly. The DVT was formed on the 1st day of modeling. With the extension of time, DVT was gradually institutionalized and finally recanalized. Lesions in the IVC and lung tissue were effectively ameliorated, and thrombosis was significantly decreased in the LMWH or 60 mg/kg Res-treated groups. The levels of D2D, F1 + 2, IL-1β, caspase-1, TF, and the expression of HIF-1α and NLRP3 were significantly reduced in the HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. Res can ameliorate DVT in rats by inhibiting HIF-1α/NLRP3 pathway, which provides a novel therapeutic strategy for DVT treatment.
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Keywords {🔍}

article, pubmed, google, scholar, cas, thrombosis, journal, central, liu, zhang, wang, res, hifα, resveratrol, deep, vein, pathway, dvt, authors, data, inflammation, manuscript, jiang, nlrp, chen, privacy, cookies, content, research, inhibiting, hifαnlrp, published, fei, qin, han, tissue, heparin, venous, information, publish, search, inflammatory, response, jianwen, xiao, junjie, lung, rats, expression, groups,

Topics {✒️}

hypoxia-inducible factor-1α/cyclo-oxygenase-2 pathway long-term low-molecular-weight heparin inferior vena cava mediates nlrp3 inflammasome-dependent-pyroptotic low-molecular-weight heparin inhibiting hif-1α/nlrp3 pathway 60 mg/kg res-treated groups nlrp3/caspase-1/il-1β pathway hif-1α inhibitor + res groups month download article/chapter hypoxia-inducible factor 1α hypoxia inducible factor-1α deep vein thrombosis mir-135b protects cardiomyocytes article inflammation aims inflammatory bowel disease key research hif-1α inhibitor hif-1α expression full article pdf privacy choices/manage cookies nlrp3-inflammasome activation inhibits arterial thrombosis nuclear factor-κb world thrombosis day animal ethics committee published article european economic area valls-de-souza post-thrombotic syndrome percutaneous mechanical thrombectomy recurrent spontaneous abortion /akt/mammalian target eugene paul cosky apoptotic cell death isth steering committee global disease burden acanthopanax senticosus polysaccharides lipopolysaccharide-challenged piglets hif-1α conditions privacy policy nlrp3 inflammasome vegf/flt-1 signaling article fei effective experimental dose improves peritoneal function murine endotoxemia model signaling pathway immune response cleveland clinic journal

Schema {🗺️}

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         description:Deep vein thrombosis (DVT) has become a prevalent and increasingly serious problem globally and resveratrol (Res) is a natural antitoxin that inhibits arterial thrombosis. To investigate the effect of Res on DVT and further explore its mechanism, thrombosis was monitored at different time points and the pathological changes occurring in the inferior vena cava (IVC) and lung tissue were observed in Sprague–Dawley rats. The protein expression of HIF-1α and NLRP3 in the IVC and lung tissue and the concentrations of D-dimer (D2D), prothrombin fragment 1 + 2 (F1 + 2), interleukin-1β (IL-1β), caspase-1, and tissue factor (TF) in the plasma were determined. After setting different doses of Res groups and using low-molecular-weight heparin (LMWH) as a positive control to determine the effective experimental dose of Res, rats were further divided into sham, DVT, HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. The above indicators were tested repeatedly. The DVT was formed on the 1st day of modeling. With the extension of time, DVT was gradually institutionalized and finally recanalized. Lesions in the IVC and lung tissue were effectively ameliorated, and thrombosis was significantly decreased in the LMWH or 60 mg/kg Res-treated groups. The levels of D2D, F1 + 2, IL-1β, caspase-1, TF, and the expression of HIF-1α and NLRP3 were significantly reduced in the HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. Res can ameliorate DVT in rats by inhibiting HIF-1α/NLRP3 pathway, which provides a novel therapeutic strategy for DVT treatment.
         datePublished:2022-06-02T00:00:00Z
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            HIF-1α/NLRP3
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            Plasma
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            Rheumatology
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            Pathology
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      headline:Resveratrol Ameliorates Deep Vein Thrombosis-Induced Inflammatory Response Through Inhibiting HIF-1α/NLRP3 Pathway
      description:Deep vein thrombosis (DVT) has become a prevalent and increasingly serious problem globally and resveratrol (Res) is a natural antitoxin that inhibits arterial thrombosis. To investigate the effect of Res on DVT and further explore its mechanism, thrombosis was monitored at different time points and the pathological changes occurring in the inferior vena cava (IVC) and lung tissue were observed in Sprague–Dawley rats. The protein expression of HIF-1α and NLRP3 in the IVC and lung tissue and the concentrations of D-dimer (D2D), prothrombin fragment 1 + 2 (F1 + 2), interleukin-1β (IL-1β), caspase-1, and tissue factor (TF) in the plasma were determined. After setting different doses of Res groups and using low-molecular-weight heparin (LMWH) as a positive control to determine the effective experimental dose of Res, rats were further divided into sham, DVT, HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. The above indicators were tested repeatedly. The DVT was formed on the 1st day of modeling. With the extension of time, DVT was gradually institutionalized and finally recanalized. Lesions in the IVC and lung tissue were effectively ameliorated, and thrombosis was significantly decreased in the LMWH or 60 mg/kg Res-treated groups. The levels of D2D, F1 + 2, IL-1β, caspase-1, TF, and the expression of HIF-1α and NLRP3 were significantly reduced in the HIF-1α inhibitor, Res, and HIF-1α inhibitor + Res groups. Res can ameliorate DVT in rats by inhibiting HIF-1α/NLRP3 pathway, which provides a novel therapeutic strategy for DVT treatment.
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         HIF-1α/NLRP3
         Inferior vena cava
         Lung
         Plasma
         Immunology
         Rheumatology
         Pharmacology/Toxicology
         Pathology
         Internal Medicine
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