We are analyzing https://link.springer.com/article/10.1007/s10753-014-9980-4.

Title:
The Alteration and Clinical Significance of Th1/Th2/Th17/Treg Cells in Patients with Multiple Myeloma | Inflammation
Description:
Immunological T cells and associated cytokines have been shown to be involved in the pathogenesis of multiple myeloma (MM). However, the abnormal immune imbalance of T lymphocyte subsets on MM remains unknown. We investigate the proportions of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cells in peripheral blood mononuclear cells (PBMCs) by flow cytometry (FCM), and serum levels of relevant cytokines in MM patients and controls were detected by enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expression of T-bet, STAT6, RORgammat, and Foxp3 was measured by real-time quantitative polymerase chain reaction (PCR). The CD4+ Th1 and CD4+ Th17 cells in patients with MM were significantly higher than those in health controls as well as the expression of T-bet and RORgammat mRNA. Furthermore, serum levels of interferon gamma (IFN-γ), IL-6, and IL-17A in MM group were greatly increased and significantly associated with each other. Significant differences on Th cells, cytokines, and transcription factors were observed on MM patients. The imbalance of T lymphocyte subsets was thought to contribute to the pathogenesis and underlying mechanisms of MM.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

article, cells, pubmed, google, scholar, cas, patients, myeloma, multiple, immunology, regulatory, access, nature, privacy, cookies, content, journal, research, yan, imbalance, expression, information, publish, search, inflammation, clinical, feng, shun, yang, subsets, levels, data, log, significance, ping, ruhong, dai, cytokines, peripheral, blood, serum, foxp, increased, open, thtreg, discover, tcell, download, china, author,

Topics {✒️}

th1/th2/th17/treg cells month download article/chapter regulatory t-cell differentiation enzyme-linked immunosorbent assay superior progression-free survival th17/treg imbalance related subjects type 1 diabetes t-cell subsets article inflammation aims full article pdf privacy choices/manage cookies cd4+ th17 cells abnormal immune imbalance th17/treg cells myeloma regulatory multiple myeloma published check access instant access article feng european economic area acute coronary syndrome shun yang /th2/th17/ conditions privacy policy foxp3-dependent programme experimental autoimmune encephalomyelitis th17 cells increased activated regulatory accepting optional cookies article log th1/th2 mm remains unknown multiple myeloma patients t-bet cell subsets author information authors enhances foxp3 expression article cite aging treg journal finder publish multiple myeloma leukemia research 37 ruhong yan usage analysis nature immunology 6 nature immunology 8 cd4+ th1 privacy policy personal data

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Alteration and Clinical Significance of Th1/Th2/Th17/Treg Cells in Patients with Multiple Myeloma
         description:Immunological T cells and associated cytokines have been shown to be involved in the pathogenesis of multiple myeloma (MM). However, the abnormal immune imbalance of T lymphocyte subsets on MM remains unknown. We investigate the proportions of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cells in peripheral blood mononuclear cells (PBMCs) by flow cytometry (FCM), and serum levels of relevant cytokines in MM patients and controls were detected by enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expression of T-bet, STAT6, RORgammat, and Foxp3 was measured by real-time quantitative polymerase chain reaction (PCR). The CD4+ Th1 and CD4+ Th17 cells in patients with MM were significantly higher than those in health controls as well as the expression of T-bet and RORgammat mRNA. Furthermore, serum levels of interferon gamma (IFN-γ), IL-6, and IL-17A in MM group were greatly increased and significantly associated with each other. Significant differences on Th cells, cytokines, and transcription factors were observed on MM patients. The imbalance of T lymphocyte subsets was thought to contribute to the pathogenesis and underlying mechanisms of MM.
         datePublished:2014-07-18T00:00:00Z
         dateModified:2014-07-18T00:00:00Z
         pageStart:705
         pageEnd:709
         sameAs:https://doi.org/10.1007/s10753-014-9980-4
         keywords:
            multiple myeloma
            Th1
            Th2
            Th17
            Treg
            Immunology
            Rheumatology
            Pharmacology/Toxicology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig3_HTML.gif
         isPartOf:
            name:Inflammation
            issn:
               1573-2576
               0360-3997
            volumeNumber:38
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ping Feng
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ruhong Yan
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoli Dai
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaofang Xie
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huiyan Wen
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shun Yang
               affiliation:
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:The Second Affiliated Hospital of Soochow University
                     address:
                        name:Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Alteration and Clinical Significance of Th1/Th2/Th17/Treg Cells in Patients with Multiple Myeloma
      description:Immunological T cells and associated cytokines have been shown to be involved in the pathogenesis of multiple myeloma (MM). However, the abnormal immune imbalance of T lymphocyte subsets on MM remains unknown. We investigate the proportions of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cells in peripheral blood mononuclear cells (PBMCs) by flow cytometry (FCM), and serum levels of relevant cytokines in MM patients and controls were detected by enzyme-linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expression of T-bet, STAT6, RORgammat, and Foxp3 was measured by real-time quantitative polymerase chain reaction (PCR). The CD4+ Th1 and CD4+ Th17 cells in patients with MM were significantly higher than those in health controls as well as the expression of T-bet and RORgammat mRNA. Furthermore, serum levels of interferon gamma (IFN-γ), IL-6, and IL-17A in MM group were greatly increased and significantly associated with each other. Significant differences on Th cells, cytokines, and transcription factors were observed on MM patients. The imbalance of T lymphocyte subsets was thought to contribute to the pathogenesis and underlying mechanisms of MM.
      datePublished:2014-07-18T00:00:00Z
      dateModified:2014-07-18T00:00:00Z
      pageStart:705
      pageEnd:709
      sameAs:https://doi.org/10.1007/s10753-014-9980-4
      keywords:
         multiple myeloma
         Th1
         Th2
         Th17
         Treg
         Immunology
         Rheumatology
         Pharmacology/Toxicology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10753-014-9980-4/MediaObjects/10753_2014_9980_Fig3_HTML.gif
      isPartOf:
         name:Inflammation
         issn:
            1573-2576
            0360-3997
         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ping Feng
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ruhong Yan
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoli Dai
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaofang Xie
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huiyan Wen
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shun Yang
            affiliation:
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:The Second Affiliated Hospital of Soochow University
                  address:
                     name:Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Inflammation
      issn:
         1573-2576
         0360-3997
      volumeNumber:38
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
      name:The Second Affiliated Hospital of Soochow University
      address:
         name:Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ping Feng
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ruhong Yan
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xiaoli Dai
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xiaofang Xie
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Huiyan Wen
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Shun Yang
      affiliation:
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:The Second Affiliated Hospital of Soochow University
            address:
               name:Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
      name:Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(86)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.13s.

LINK . SPRINGER . COM {}