We are analyzing https://link.springer.com/article/10.1007/s10741-010-9180-8.

Title:
TNFα in myocardial ischemia/reperfusion, remodeling and heart failure | Heart Failure Reviews
Description:
TNFα is crucially involved in the pathogenesis and progression of myocardial ischemia/reperfusion injury and heart failure. The formation and release of TNFα and its downstream signal transduction cascade following activation of its two receptor subtypes are characterized. Myocardial TNFα and TNF receptor activation have an ambivalent role in myocardial ischemia/reperfusion injury and protection from it. Excessive TNFα expression and subsequent cardiomyocyte TNF receptor type 1 stimulation induce contractile dysfunction, hypertrophy, fibrosis and cell death, while a lower TNFα concentration and subsequent cardiomyocyte TNF receptor type 2 stimulation are protective. Apart from its concentration and receptor subtype, the myocardial action of TNFα depends on the duration of its exposure and its localization. While detrimental during sustained ischemia, TNFα contributes to ischemic preconditioning protection, no matter whether it is the first, second or third window of protection, and both TNF receptors are involved in the protective signal transduction cascade. Finally, the available clinical attempts to antagonize TNFα in cardiovascular disease, notably heart failure, are critically discussed.
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Keywords {🔍}

google, scholar, pubmed, cas, necrosis, tumor, heart, factor, myocardial, failure, res, cardiac, physiol, cardiol, cell, circulation, tnfα, factorα, heusch, schulz, role, receptor, circ, activation, dysfunction, ischemic, preconditioning, biol, expression, mol, tnf, mann, human, cardiovasc, patients, nitric, oxide, chronic, apoptosis, infarction, inflammatory, signaling, chem, injury, receptors, basic, wang, cytokines, factoralpha, mice,

Topics {✒️}

tnf-α-induced cardiomyocyte hypertrophy releases tumour-necrosis factor-α rainer schulz & gerd heusch l-arginine/nitric oxide pathway peripheral view cytokines profile tumor necrosis factor-α tumor necrosis factor-alpha tumour necrosis factor-alpha α-adrenergic receptor augments tnf-induced mitochondrial damage tnf-α-induced depression month download article/chapter tnf-α—induced cardiomyopathy fgf-inducible 14-kda protein endotoxin-induced serum factor author correspondence myocardial tnf-α concentration tnf-α receptors p55 tnf-alpha-induced impairment myocardial ischemia/reperfusion injury nuclear factor-κb activation rhoa/rock kinase pathway release preformed tnf-α pi3 kγ-dependent manner pacing-induced cardiac failure tumor necrosis factor tumor necrosis factor pacing-induced heart failure modulate ischemia/reperfusion injury tnfr2-traf signaling complex tumour necrosis factor sphingosine-1-phosphate induced cardioprotection reactive oxygen species cis-acting promoter sequences nitric oxide synthesis tnfr2-mediated signaling pathways cyclooxygenase-2-derived thromboxane production nf-κb-mediated transcription al-lamki rs transcription factor nf-kappa mitogen-activated protein kinases phosphatidylinositol 3-kinase/akt pathway myocardial jak/stat pathway extracellular signal-regulated kinase cardiac nf-kappab activation tnf-mediated inflammatory disease tnf-alpha secretion sex-related survival differences heart failure published

Questions {❓}

Ceconi C, Curello S, Bachetti T, Corti A, Ferrari R (1998) Tumor necrosis factor in congestive heart failure: a mechanism of disease for the new millennium?
Fildes JE, Shaw SM, Yonan N, Williams SG (2009) The immune system and chronic heart failure: is the heart in control?
Goodman MD, Koch SE, Fuller-Bicer GA, Butler KL (2008) Regulating RISK: a role for JAK-STAT signaling in postconditioning?
Knuefermann P, Nemoto S, Baumgarten G, Misra A, Sivasubramanian N, Carabello BA, Vallejo JG (2002) Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors?
Lecour S (2009) Activation of the protective survivor activating factore enhancement (SAFE) pathway against reperfusion injury: does it go beyond the RISK path?
Old wine in a new bottle?
Ovize M, Baxter GF, Di LF, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R (2010) Postconditioning and protection from reperfusion injury: where do we stand?
Schulz R, Heusch G (2009) Tumor necrosis factor-alpha and its receptors 1 and 2: Yin and Yang in myocardial infarction?
Slayer or savior ?
Torre-Amione G, Stetson S, Vooletich M, Jacobs V, Youker KA (1999) Tumor necrosis factor-α in the failing human heart: does it play a role in disease progression?

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      description:TNFα is crucially involved in the pathogenesis and progression of myocardial ischemia/reperfusion injury and heart failure. The formation and release of TNFα and its downstream signal transduction cascade following activation of its two receptor subtypes are characterized. Myocardial TNFα and TNF receptor activation have an ambivalent role in myocardial ischemia/reperfusion injury and protection from it. Excessive TNFα expression and subsequent cardiomyocyte TNF receptor type 1 stimulation induce contractile dysfunction, hypertrophy, fibrosis and cell death, while a lower TNFα concentration and subsequent cardiomyocyte TNF receptor type 2 stimulation are protective. Apart from its concentration and receptor subtype, the myocardial action of TNFα depends on the duration of its exposure and its localization. While detrimental during sustained ischemia, TNFα contributes to ischemic preconditioning protection, no matter whether it is the first, second or third window of protection, and both TNF receptors are involved in the protective signal transduction cascade. Finally, the available clinical attempts to antagonize TNFα in cardiovascular disease, notably heart failure, are critically discussed.
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