We are analyzing https://link.springer.com/article/10.1007/s10719-023-10102-1.

Title:
Fluorescent GD2 analog for single-molecule imaging | Glycoconjugate Journal
Description:
Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
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Keywords {🔍}

article, pubmed, google, scholar, cas, ishida, ando, ganglioside, singlemolecule, tanaka, imamura, cell, imaging, suzuki, chem, fluorescent, komura, synthesis, biol, central, content, data, information, research, interactions, nat, kgn, kiso, privacy, cookies, journal, gangliosides, nature, grant, authors, springer, publish, search, published, january, yamaguchi, membranes, lipid, raft, access, membrane, total, japan, author, gifu,

Topics {✒️}

sophie groux-degroote p-tert-butyl groups improve month download article/chapter single-molecule imaging fluorescent gd2 analog gpi-anchored receptor breast cancer cells developed fluorescent analogs fluorescent ganglioside gd3 elucidating molecular interactions lipid raft formation lipid raft organization université de lille called lipid rafts disialoganglioside gd2 expression full article pdf privacy choices/manage cookies fluorescent ganglioside related subjects glyco-core research 2023 raft-based interactions raft-based interactions synthesized analog revealed aromatic protecting groups membrane protein regulation raft-philic character sialic acid dependence author information authors holds exclusive rights journal finder publish published article european economic area late-stage sialylation fluorescently labeled galnac applied bioorganic chemistry studies involving humans accepted manuscript version membrane molecules mobile conditions privacy policy electronic supplementary material article yamaguchi revitalizing membrane rafts hide-nori tanaka additional information publisher accepting optional cookies core program grant cell plasma membranes fluorescently labeled ssea-3 funding organizations listed hannover medical school

Schema {🗺️}

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         headline:Fluorescent GD2 analog for single-molecule imaging
         description:Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
         datePublished:2023-01-26T00:00:00Z
         dateModified:2023-01-26T00:00:00Z
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            Single-molecule imaging
            Ganglioside
            GD2
            Biochemistry
            general
            Pathology
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      headline:Fluorescent GD2 analog for single-molecule imaging
      description:Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
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         Single-molecule imaging
         Ganglioside
         GD2
         Biochemistry
         general
         Pathology
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      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
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      name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
      name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
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