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Title:
Gene mapping in the wild with SNPs: guidelines and future directions | Genetica
Description:
One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.
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google, scholar, article, pubmed, cas, linkage, snp, ecol, mapping, genome, mol, genetics, disequilibrium, genet, slate, single, polymorphism, nucleotide, genotyping, population, data, populations, markers, notes, visscher, wild, gratten, natural, genomewide, genomics, nat, loci, genetic, discovery, polymorphisms, analysis, gene, beraldi, map, association, res, biol, sci, studies, bmc, quantitative, qtl, proc, human, evolutionary,
Topics {βοΈ}
month download article/chapter genome-wide single-nucleotide polymorphisms cost-effective initial screens family-based association tests intron-primed exon-crossing single-nucleotide polymorphism discovery genome-wide association studies free-living vertebrate population detecting marker-qtl linkage breed-specific linkage disequilibrium free-living sheep population long-term pedigree data broad cross-species applicability single nucleotide polymorphism free-living soay sheep high-throughput genotyping full article pdf takes large-scale genomics gene-based set single-nucleotide polymorphisms genome-wide analysis single tube assay single nucleotide substitution article genetica aims related subjects related amanita phalloides privacy choices/manage cookies saturated genetic-map anonymous nuclear markers free-living population integrating qtl mapping kruuk leb quantitative trait loci candidate gene analysis accessing genetic variation bovine est data redundancy based detection targeted-gene approach snplex genotyping system optimal marker density genomewide association studies estimating genetic parameters gene order rearrangements high-throughput development human expressed sequences map fitness genes simple regression method porcine expressed genes evolutionary quantitative genetics dense snp arrays
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headline:Gene mapping in the wild with SNPs: guidelines and future directions
description:One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.
datePublished:2008-09-09T00:00:00Z
dateModified:2008-09-09T00:00:00Z
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Gene discovery
QTL
Linkage
Mapping
SNP
Wild population
Animal Genetics and Genomics
Plant Genetics and Genomics
Evolutionary Biology
Human Genetics
Microbial Genetics and Genomics
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headline:Gene mapping in the wild with SNPs: guidelines and future directions
description:One of the biggest challenges facing evolutionary biologists is to identify and understand loci that explain fitness variation in natural populations. This review describes how genetic (linkage) mapping with single nucleotide polymorphism (SNP) markers can lead to great progress in this area. Strategies for SNP discovery and SNP genotyping are described and an overview of how to model SNP genotype information in mapping studies is presented. Finally, the opportunity afforded by new generation sequencing and typing technologies to map fitness genes by genome-wide association studies is discussed.
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dateModified:2008-09-09T00:00:00Z
pageStart:97
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Gene discovery
QTL
Linkage
Mapping
SNP
Wild population
Animal Genetics and Genomics
Plant Genetics and Genomics
Evolutionary Biology
Human Genetics
Microbial Genetics and Genomics
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