We are analyzing https://link.springer.com/article/10.1007/s10689-016-9869-5.

Title:
CDH1 germline mutations and hereditary lobular breast cancer | Familial Cancer
Description:
Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. Recently, novel E-cadherin constitutional alterations have been identified in pedigree clustering only for lobular breast carcinoma without evidence of diffuse gastric tumors and in absence of BRCA1/2 mutations. This first evidence opens novel questions about the inherited correlation between diffuse gastric and lobular breast cancers. In this brief review we revise the literature data about the CDH1 mutation frequency affecting exclusively lobular breast cancer, providing clinical recommendation for asymptomatic mutation carriers.
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Keywords {🔍}

pubmed, article, cancer, google, scholar, breast, lobular, cas, germline, mutations, gastric, ecadherin, carcinoma, central, cdh, hereditary, invasive, diffuse, familial, corso, mutation, med, syndrome, gene, genet, imaging, privacy, cookies, content, cancers, access, oncol, data, publish, search, review, clinical, dois, clin, management, ultrasound, european, information, log, journal, research, giovanni, intra, trentin, veronesi,

Topics {✒️}

cadherin-mediated cell–cell adhesion cell-adhesion molecule e-cadherin month download article/chapter e-cadherin germline mutation e-cadherin mutant cells e-cadherin germline mutations germline e-cadherin mutations e-cadherin constitutional alterations breast-specific gamma imaging hereditary breast cancer e-cadherin gene asymptomatic mutation carriers lobular breast cancers lobular breast cancer tumour-suppressor gene full article pdf hereditary diffuse gastric familial gastric cancer e-cadherin protein e-cadherin expression diffuse gastric cancer germline cdh1 variants lobular breast carcinoma lobular breast carcinomas privacy choices/manage cookies cdh1 germline mutations germline cdh1 mutations article corso invasive lobular carcinoma breast lobular neoplasia bmc cancer 12 bilateral lobular carcinoma related subjects diffuse gastric tumors infiltrating lobular carcinoma gastric carcinoma coming breast cancers diffuse type gastric breast cancer familial cancer 15 e-cadherin nipple sparing mastectomy nipple-sparing mastectomy ethics declarations conflict conditions privacy policy low-risk areas article log providing clinical recommendation retrospective study comparing european economic area

Questions {❓}

Petit JY, Veronesi U, Lohsiriwat V et al (2011) Nipple-sparing mastectomy-is it worth the risk?

Schema {🗺️}

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         description:Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. Recently, novel E-cadherin constitutional alterations have been identified in pedigree clustering only for lobular breast carcinoma without evidence of diffuse gastric tumors and in absence of BRCA1/2 mutations. This first evidence opens novel questions about the inherited correlation between diffuse gastric and lobular breast cancers. In this brief review we revise the literature data about the CDH1 mutation frequency affecting exclusively lobular breast cancer, providing clinical recommendation for asymptomatic mutation carriers.
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         dateModified:2016-01-13T00:00:00Z
         pageStart:215
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            E-cadherin germline mutation
            Hereditary breast cancer
            Cancer Research
            Human Genetics
            Epidemiology
            Biomedicine
            general
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      headline:CDH1 germline mutations and hereditary lobular breast cancer
      description:Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. Recently, novel E-cadherin constitutional alterations have been identified in pedigree clustering only for lobular breast carcinoma without evidence of diffuse gastric tumors and in absence of BRCA1/2 mutations. This first evidence opens novel questions about the inherited correlation between diffuse gastric and lobular breast cancers. In this brief review we revise the literature data about the CDH1 mutation frequency affecting exclusively lobular breast cancer, providing clinical recommendation for asymptomatic mutation carriers.
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      dateModified:2016-01-13T00:00:00Z
      pageStart:215
      pageEnd:219
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         Lobular breast cancer
         E-cadherin germline mutation
         Hereditary breast cancer
         Cancer Research
         Human Genetics
         Epidemiology
         Biomedicine
         general
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10689-016-9869-5/MediaObjects/10689_2016_9869_Fig1_HTML.gif
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