We are analyzing https://link.springer.com/article/10.1007/s10659-025-10120-0.

Title:
Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers | Journal of Elasticity
Description:
Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation and death, is essential for the development, growth, maintenance, and proper function of living organisms. Disruptions to this process can lead to serious diseases and even death. In this study, we use the vertex model for the cell-level description of tissue mechanics to investigate the impact of the tissue environment and local mechanical properties of cells on homeostasis in confined epithelial tissues. We find a dynamic steady state, where the balance between cell divisions and removals sustains homeostasis, and characterise the homeostatic state in terms of cell count, tissue area, homeostatic pressure, and the cells’ neighbour count distribution. This work, therefore, sheds light on the mechanisms underlying tissue homeostasis and highlights the importance of mechanics in its control.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, cell, active, tissue, google, scholar, passive, fig, area, shape, target, mechanical, ptextp, homeostasis, ptexta, index, alpha, number, values, initial, growth, model, time, barfn, epithelial, division, size, configuration, vertex, divisions, change, state, ingressions, confinement, probability, barfa, biol, models, beta, full, homeostatic, distribution, simulation, increases, rev, count, neighbour, fractional, sknepnek, region,

Topics {✒️}

e-cadherin molecules concentrated including particle-based models [24–26] determining cell-packing geometries extra-embryonic tissue encircling ell _{\text{t1}}^{\text{ article download pdf rastko sknepnek particle-based models full size image materials research science text{cells}} \left [\frac{k_{ privacy choices/manage cookies confined epithelial monolayers cellular potts models [31 ell _{\text{t1}} 02\ell _{\text{t1}} epithelial tissue mechanics realised shape index cell neighbour counts author information authors include cellular processes epithelial cells consisting confined epithelial tissues nonequilibrium statistical mechanics full access explore tissue homeostasis growing epithelial tissues identifying physical mechanisms innovation research grant motility homeostasis mechanics epithelial tissue homeostasis related subjects continuous density fields error bars represent view biology search search extra-embryonic tissue phase-field methods [27–30] target shape index cell neighbour count remains approximately constant original author cellular potts model propelled voronoi models �simulation” units chosen target shape indexes target shape indices confined planar epithelia cell neighbour exchanges [61] cell neighbour exchanges

Schema {🗺️}

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         description:Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation and death, is essential for the development, growth, maintenance, and proper function of living organisms. Disruptions to this process can lead to serious diseases and even death. In this study, we use the vertex model for the cell-level description of tissue mechanics to investigate the impact of the tissue environment and local mechanical properties of cells on homeostasis in confined epithelial tissues. We find a dynamic steady state, where the balance between cell divisions and removals sustains homeostasis, and characterise the homeostatic state in terms of cell count, tissue area, homeostatic pressure, and the cells’ neighbour count distribution. This work, therefore, sheds light on the mechanisms underlying tissue homeostasis and highlights the importance of mechanics in its control.
         datePublished:2025-02-24T00:00:00Z
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            Materials Science
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      headline:Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers
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         Classical Mechanics
         Materials Science
         general
         Biomechanics
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