We are analyzing https://link.springer.com/article/10.1007/s10620-009-0733-4.

Title:
Deficient Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Chronic Hepatitis B Viral Infections and Cirrhosis of the Liver | Digestive Diseases and Sciences
Description:
In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
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Keywords {🔍}

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Topics {✒️}

zhao-feng tang & rui-yun xu pre-s1 antigen-dependent infection month download article/chapter rui-yun xu serum bone gla-protein marrow stromal cells hedgehog-mediated paracrine interaction sun yat-sen university circulating pdc1/pdc2 ratio article digestive diseases cir-mscs decreased compared experimental liver fibrosis full article pdf bone marrow dynamic bone histomorphometry related subjects privacy choices/manage cookies hepatic stellate cells plasmacytoid dendritic cells s-phase nuclei chronic liver disease infectious diseases’ laboratory biliary tract cancer article zhong detecting hbv infections gene expression profile decompensated liver cirrhosis european economic area growth factor receptors vivo generated dc1 3rd affiliated hospital conditions privacy policy indicating impaired proliferation technology development fund professor lin yang 10 circulating cytokines/chemokines low turnover osteoporosis author information authors fu-cheng zhang arch iran med clin endocrinol metab cir-mscs displayed accepting optional cookies mei-hai deng albino rats—similarities tupaia hepatocyte cultures population-based study dendritic cells clin biochem med microbiol immunol

Schema {🗺️}

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         description:In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
         datePublished:2009-02-26T00:00:00Z
         dateModified:2009-02-26T00:00:00Z
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            Bone marrow-derived mesenchymal stem cells
            Proliferation
            Hepatitis B virus
            Liver cirrhosis
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
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      headline:Deficient Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Chronic Hepatitis B Viral Infections and Cirrhosis of the Liver
      description:In this study, we determined whether the proliferation of bone marrow-derived mesenchymal stem cells (MSCs) is impaired in patients with chronic hepatitis B viral infection and cirrhosis of the liver. MSCs from 15 patients with chronic hepatitis B and cirrhosis of the liver (CIR-MSCs) and 11 normal donors (ND-MSCs) were collected and characterized in vitro. CIR-MSCs displayed an intact immunophenotype. The percentage of S-phase nuclei in CIR-MSCs (4.34%), however, was significantly lower than that in ND-MSCs (P < 0.001), indicating impaired proliferation of CIR-MSCs. Growth factor receptor expression (e.g., IGF1, PDGFα, and PDGFβ) on the surface of CIR-MSCs decreased compared to that on ND-MSCs (P < 0.03). We found no evidence that CIR-MSCs were infected with the hepatitis B virus (HBV). Deficient proliferation of CIR-MSCs may result from the decreased expression of growth factor receptors and unbalanced production of cytokines in patients with HBV infection. Our results indicate that autologous MSCs of patients with chronic hepatitis B and cirrhosis of the liver may not be suitable for therapeutic purposes.
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         Bone marrow-derived mesenchymal stem cells
         Proliferation
         Hepatitis B virus
         Liver cirrhosis
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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