We are analyzing https://link.springer.com/article/10.1007/s10585-025-10353-2.

Title:
Targeting cancer cell stiffness and metastasis with clinical therapeutics | Clinical & Experimental Metastasis
Description:
Tumorigenesis and metastasis of solid tumors are coupled to profound biophysical changes that alter cancer cells’ mechanobiology, critically impacting metastatic progression. In particular, cell stiffness determines the ability of cancer cells to invade surrounding tissues, withstand shear fluid stress and evade immune surveillance. Here, we summarize the biological factors, pathological factors, and therapeutic modalities that affect the mechanobiology of cancer cells. We focus on clinically utilized chemotherapeutics and targeted therapies that show direct and indirect modulation of cancer cells’ stiffness and discuss how these treatments can be used in combination with other treatment modalities to improve patient outcomes. Finally, we list the outstanding challenges in the field and provide a perspective on expanding the clinical utilization of experimental therapeutics that can act as “mechanotherapeutics” by regulating mechanobiology of cancer cells.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, cancer, cell, article, cells, scholar, google, stiffness, cas, central, cellular, signaling, breast, treatment, tumor, nat, metastatic, mechanical, targeting, effects, pathways, metastasis, factin, membrane, drugs, immune, sci, clinical, biol, stress, force, actin, cytoskeletal, inhibitor, treatments, increases, activation, studies, stiffening, kinase, resistance, oncogenic, methods, target, cytoskeleton, inhibitors, data, mechanics, response, cytotoxic,

Topics {✒️}

rhoa/actomyosin-dependent mechano-adaptation pi3k/akt/mtor pathway inhibitors single mechano-sensitive molecules directly affect t-lymphocyte growth-induced solid stress real-time deformability cytometry article download pdf ekrem emrah er capecitabine-cisplatin versus placebo time-consuming trogocytosis process mapk-induced cell softening pi3k/akt/mtor pathways pi3k/akt/mtor inhibitors pi3k/akt signaling tips tumorigenic beta-catenin pathway promote f-actin bundling inhibit f-actin polymerization bcr-abl fusion protein mda-mb-231 breast cancer b16–f10 melanoma cells cell-ecm adhesion molecules perturbing integrin-ecm contact mda-mb-435 melanoma cells promoting f-actin bundling cisplatin anti-cancer drugs dual rock-akt inhibitor inversion-technique-based investigation clinically-relevant kinase inhibitors increasing f-actin formation focal adhesion kinase proto-oncogenic src activation fak-erk1/2 signalling pathway rapid signal transduction rate-dependent young v-atpase inhibition atomic force microscope estrogen receptor positive rodríguez-lópez atomic force microscopy renin-angiotensin system stress fiber formation tgf-beta induces brillouin spectroscopy require privacy choices/manage cookies single-cell mechanics cell-intrinsic factor perforin-mediated killing small molecule drugs subsequent cell stiffness cytotoxic t-lymphocytes

Questions {❓}

Galie PA, Georges PC, Janmey PA (2022) How do cells stiffen?

Schema {🗺️}

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      headline:Targeting cancer cell stiffness and metastasis with clinical therapeutics
      description:Tumorigenesis and metastasis of solid tumors are coupled to profound biophysical changes that alter cancer cells’ mechanobiology, critically impacting metastatic progression. In particular, cell stiffness determines the ability of cancer cells to invade surrounding tissues, withstand shear fluid stress and evade immune surveillance. Here, we summarize the biological factors, pathological factors, and therapeutic modalities that affect the mechanobiology of cancer cells. We focus on clinically utilized chemotherapeutics and targeted therapies that show direct and indirect modulation of cancer cells’ stiffness and discuss how these treatments can be used in combination with other treatment modalities to improve patient outcomes. Finally, we list the outstanding challenges in the field and provide a perspective on expanding the clinical utilization of experimental therapeutics that can act as “mechanotherapeutics” by regulating mechanobiology of cancer cells.
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