We are analyzing https://link.springer.com/article/10.1007/s10577-005-1024-3.

Title:
Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length | Chromosome Research
Description:
Despite a great deal of attention over many years, the structural and functional roles of the linker histone H1 remain enigmatic. The earlier concepts of H1 as a general transcriptional inhibitor have had to be reconsidered in the light of experiments demonstrating a minor effect of H1 deletion in unicellular organisms. More recent work analysing the results of depleting H1 in mammals through genetic knockouts of selected H1 subtypes in the mouse has shown that cells and tissues can tolerate a surprisingly low H1 content. One common feature of H1-depleted nuclei is a reduction in nucleosome repeat length (NRL). Moreover, there is a robust linear relationship between H1 stoichiometry and NRL, suggesting an inherent homeostatic mechanism that maintains intranuclear electrostatic balance. It is also clear that the 1 H1 per nucleosome paradigm for higher eukaryotes is the exception rather than the rule. This, together with the high mobility of H1 within the nucleus, prompts a reappraisal of the role of linker histone as an obligatory chromatin architectural protein.
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Keywords {🔍}

google, scholar, cas, pubmed, article, histone, chromatin, linker, biol, nucleosome, cell, structure, histones, mol, function, chem, biochem, dna, sci, usa, thomas, nature, content, natl, repeat, fan, access, binding, proc, acad, domain, gene, privacy, cookies, research, chromosome, role, length, woodcock, skoultchi, location, res, hansen, vivo, specific, essential, publish, search, cells, electrostatic,

Topics {✒️}

month download article/chapter histone-h1-dependent chromatin superstructures atp-dependent activity required transcriptionally-active mmtv promoter intrinsic salt-dependent folding c-terminal domain nucleosome repeat length full article pdf salt-dependent superstructures h10 linker histone skoultchi & yuhong fan privacy choices/manage cookies linker dna length chromatin core particle linker histone binding nucleosome repeat lengths linker histone form linker histone located linker histone h1 yeast chromatin structure histone h1 binding usage analysis carruthers lm histone h1 overexpression histone h1 family xenopus mitotic extracts xenopus laevis oocytes mitotic chromosome architecture linker histone function concurrent protein synthesis histone-dna interactions linker histone h5 linker histones stabilize linker histones provide linker histones prevent linker histones inside regulating chromatin structure determining chromatin structure h1 linker histones newly replicated chromatin chicken erythrocyte chromatin downs ja nucleosome arrays depends nucleosome arrays reveal histone h1 function x-ray structure european economic area recent work analysing crane-robinson native replication forks

Questions {❓}

Ausio J (2000) Are linker histones (histone H1) dispensable for survival?
Crane-Robinson C (1997) Where is the globular domain of linker histone located on the nucleosome?
Crane-Robinson C (1999) How do linker histones mediate differential gene expression?
Harvey AC, Downs JA (2004) What functions do linker histones provide?
Roth SY, Allis CD (1992) Chromatin condensation: does H1 phosphorylation play a role?
Wolffe AP, Khochbin S, Dimitrov S (1997) What do linker histones do in chromatin?

Schema {🗺️}

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         description:Despite a great deal of attention over many years, the structural and functional roles of the linker histone H1 remain enigmatic. The earlier concepts of H1 as a general transcriptional inhibitor have had to be reconsidered in the light of experiments demonstrating a minor effect of H1 deletion in unicellular organisms. More recent work analysing the results of depleting H1 in mammals through genetic knockouts of selected H1 subtypes in the mouse has shown that cells and tissues can tolerate a surprisingly low H1 content. One common feature of H1-depleted nuclei is a reduction in nucleosome repeat length (NRL). Moreover, there is a robust linear relationship between H1 stoichiometry and NRL, suggesting an inherent homeostatic mechanism that maintains intranuclear electrostatic balance. It is also clear that the 1 H1 per nucleosome paradigm for higher eukaryotes is the exception rather than the rule. This, together with the high mobility of H1 within the nucleus, prompts a reappraisal of the role of linker histone as an obligatory chromatin architectural protein.
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