We are analyzing https://link.springer.com/article/10.1007/s10571-020-00966-4.

Title:
Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease | Cellular and Molecular Neurobiology
Description:
Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was demonstrated both in vitro and in animal models, and was confirmed in humans. IS evokes an immediate inflammatory response that involves complex cellular and molecular mechanisms. All components of the innate and adaptive immunity systems are involved in several steps of the ischemic cascade. In the early phase, inflammatory and immune mechanisms contribute to the brain tissue damage, whereas, in the late phase, they participate to the tissue repair processes. In particular, damage-associated molecular patterns (DAMPs) appear critical for the promotion of altered blood brain barrier permeability, leukocytes infiltration, tissue edema and brain injury. Conversely, the activation of regulatory T lymphocytes (Tregs) plays protective effects. The identification of specific cellular/molecular elements belonging to the inflammatory and immune responses, contributing to the brain ischemic injury and tissue remodeling, offers the advantage to design adequate therapeutic strategies. In this article, we will present an overview of the knowledge on inflammatory and immunity processes in IS, with a particular focus on the role of DAMPs and leukocytes infiltration. We will discuss evidence obtained in preclinical models of IS and in humans. The main molecular mechanisms useful for the development of novel therapeutic approaches will be highlighted. The translation of experimental findings to the human disease is still a difficult step to pursue. Further investigations are required to fill up the existing gaps.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cas, stroke, central, ischemic, brain, cerebral, ischemia, acute, role, cell, inflammation, immune, injury, med, blood, httpsdoiorg, httpsdoiorgs, inflammatory, cells, neurol, molecular, rat, chen, zhang, liu, yang, zhou, damps, immunity, therapeutic, receptor, nat, shock, transient, neurosci, group, box, hmgb, human, disease, damage, regulatory, focal, signaling, protein, models,

Topics {✒️}

month download article/chapter blood–brain barrier breakdown c-reactive protein concentration connolly es jr ifn-gamma mrna expression cytokine-induced endothelial cells writing—original draft preparation p-selectin deficient mice acute anti-inflammatory approaches phthalide derivative cd21 intercellular adhesion molecule-1 adaptive dose-response study individual participant meta-analysis trif-adaptor independent toll full article pdf reperfusion injury induced chronic cerebrovascular disease acute cerebral infarction toledo-pereyra lh photochemically induced ischemia heat shock proteins signaling pathway blockade microvascular dysfunction induced privacy choices/manage cookies anti-vcam-1 antibodies anti-icam-1 therapy todd rf 3rd anti-leukocyte antibodies brain ischemic injury ischemic brain injury post-ischemic inflammation uric acid promotes tissue repair processes article cellular focal cerebral ischemia immunomodulatory therapeutic strategies neuronal cell death global cerebral ischemia article stanzione american heart association conditions privacy policy steady plasma concentration brain tissue damage central role lymphocyte trafficking shields local immune responses li yj transient ischemic stroke involves complex cellular early release

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease
         description:Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was demonstrated both in vitro and in animal models, and was confirmed in humans. IS evokes an immediate inflammatory response that involves complex cellular and molecular mechanisms. All components of the innate and adaptive immunity systems are involved in several steps of the ischemic cascade. In the early phase, inflammatory and immune mechanisms contribute to the brain tissue damage, whereas, in the late phase, they participate to the tissue repair processes. In particular, damage-associated molecular patterns (DAMPs) appear critical for the promotion of altered blood brain barrier permeability, leukocytes infiltration, tissue edema and brain injury. Conversely, the activation of regulatory T lymphocytes (Tregs) plays protective effects. The identification of specific cellular/molecular elements belonging to the inflammatory and immune responses, contributing to the brain ischemic injury and tissue remodeling, offers the advantage to design adequate therapeutic strategies. In this article, we will present an overview of the knowledge on inflammatory and immunity processes in IS, with a particular focus on the role of DAMPs and leukocytes infiltration. We will discuss evidence obtained in preclinical models of IS and in humans. The main molecular mechanisms useful for the development of novel therapeutic approaches will be highlighted. The translation of experimental findings to the human disease is still a difficult step to pursue. Further investigations are required to fill up the existing gaps.
         datePublished:2020-09-29T00:00:00Z
         dateModified:2020-09-29T00:00:00Z
         pageStart:545
         pageEnd:556
         sameAs:https://doi.org/10.1007/s10571-020-00966-4
         keywords:
            Ischemic stroke
            Inflammation
            Immunity
            MCAO
            Damps
            Leukocytes
            Neurosciences
            Cell Biology
            Neurobiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-020-00966-4/MediaObjects/10571_2020_966_Fig1_HTML.png
         isPartOf:
            name:Cellular and Molecular Neurobiology
            issn:
               1573-6830
               0272-4340
            volumeNumber:42
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Rosita Stanzione
               url:http://orcid.org/0000-0002-3576-4604
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Maurizio Forte
               url:http://orcid.org/0000-0003-0739-0534
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maria Cotugno
               url:http://orcid.org/0000-0003-0061-1154
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Franca Bianchi
               url:http://orcid.org/0000-0001-7355-4694
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Simona Marchitti
               url:http://orcid.org/0000-0002-9097-8496
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Speranza Rubattu
               url:http://orcid.org/0000-0002-9808-7970
               affiliation:
                     name:IRCCS Neuromed
                     address:
                        name:IRCCS Neuromed, Pozzilli, Italy
                        type:PostalAddress
                     type:Organization
                     name:Sapienza University of Rome
                     address:
                        name:Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease
      description:Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was demonstrated both in vitro and in animal models, and was confirmed in humans. IS evokes an immediate inflammatory response that involves complex cellular and molecular mechanisms. All components of the innate and adaptive immunity systems are involved in several steps of the ischemic cascade. In the early phase, inflammatory and immune mechanisms contribute to the brain tissue damage, whereas, in the late phase, they participate to the tissue repair processes. In particular, damage-associated molecular patterns (DAMPs) appear critical for the promotion of altered blood brain barrier permeability, leukocytes infiltration, tissue edema and brain injury. Conversely, the activation of regulatory T lymphocytes (Tregs) plays protective effects. The identification of specific cellular/molecular elements belonging to the inflammatory and immune responses, contributing to the brain ischemic injury and tissue remodeling, offers the advantage to design adequate therapeutic strategies. In this article, we will present an overview of the knowledge on inflammatory and immunity processes in IS, with a particular focus on the role of DAMPs and leukocytes infiltration. We will discuss evidence obtained in preclinical models of IS and in humans. The main molecular mechanisms useful for the development of novel therapeutic approaches will be highlighted. The translation of experimental findings to the human disease is still a difficult step to pursue. Further investigations are required to fill up the existing gaps.
      datePublished:2020-09-29T00:00:00Z
      dateModified:2020-09-29T00:00:00Z
      pageStart:545
      pageEnd:556
      sameAs:https://doi.org/10.1007/s10571-020-00966-4
      keywords:
         Ischemic stroke
         Inflammation
         Immunity
         MCAO
         Damps
         Leukocytes
         Neurosciences
         Cell Biology
         Neurobiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10571-020-00966-4/MediaObjects/10571_2020_966_Fig1_HTML.png
      isPartOf:
         name:Cellular and Molecular Neurobiology
         issn:
            1573-6830
            0272-4340
         volumeNumber:42
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Rosita Stanzione
            url:http://orcid.org/0000-0002-3576-4604
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Maurizio Forte
            url:http://orcid.org/0000-0003-0739-0534
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maria Cotugno
            url:http://orcid.org/0000-0003-0061-1154
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Franca Bianchi
            url:http://orcid.org/0000-0001-7355-4694
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Simona Marchitti
            url:http://orcid.org/0000-0002-9097-8496
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Speranza Rubattu
            url:http://orcid.org/0000-0002-9808-7970
            affiliation:
                  name:IRCCS Neuromed
                  address:
                     name:IRCCS Neuromed, Pozzilli, Italy
                     type:PostalAddress
                  type:Organization
                  name:Sapienza University of Rome
                  address:
                     name:Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Neurobiology
      issn:
         1573-6830
         0272-4340
      volumeNumber:42
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:IRCCS Neuromed
      address:
         name:IRCCS Neuromed, Pozzilli, Italy
         type:PostalAddress
      name:Sapienza University of Rome
      address:
         name:Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Rosita Stanzione
      url:http://orcid.org/0000-0002-3576-4604
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Maurizio Forte
      url:http://orcid.org/0000-0003-0739-0534
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
      name:Maria Cotugno
      url:http://orcid.org/0000-0003-0061-1154
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
      name:Franca Bianchi
      url:http://orcid.org/0000-0001-7355-4694
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
      name:Simona Marchitti
      url:http://orcid.org/0000-0002-9097-8496
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
      name:Speranza Rubattu
      url:http://orcid.org/0000-0002-9808-7970
      affiliation:
            name:IRCCS Neuromed
            address:
               name:IRCCS Neuromed, Pozzilli, Italy
               type:PostalAddress
            type:Organization
            name:Sapienza University of Rome
            address:
               name:Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:IRCCS Neuromed, Pozzilli, Italy
      name:IRCCS Neuromed, Pozzilli, Italy
      name:IRCCS Neuromed, Pozzilli, Italy
      name:IRCCS Neuromed, Pozzilli, Italy
      name:IRCCS Neuromed, Pozzilli, Italy
      name:IRCCS Neuromed, Pozzilli, Italy
      name:Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(541)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.3s.

LINK . SPRINGER . COM {}