We are analyzing https://link.springer.com/article/10.1007/s10571-016-0456-y.

Title:
RUNX1 Regulates Migration, Invasion, and Angiogenesis via p38 MAPK Pathway in Human Glioblastoma | Cellular and Molecular Neurobiology
Description:
Runt-related transcription factor 1 (RUNX1) is essential for the establishment of fetal and adult hematopoiesis and neuronal development. Aberrant expression of RUNX1 led to proliferation and metastasis of several cancers. The aim of the present study was to investigate the role of RUNX1 in migration, invasion, and angiogenesis of human glioblastoma using IL-1β-treated U-87 MG human glioblastoma cells as a model. IL-1β at 10 ng/ml stimulated translocation of RUNX1 into the nucleus with increased expressions of RUNX1, MMP-1, MMP-2, MMP-9, MMP-19, and VEGFA in U-87 MG cells. In addition, silencing of RUNX1 gene significantly suppressed U-87 MG cell migration and invasion abilities. Moreover, knockdown of RUNX1 mRNA in U-87 MG cells reduced the tube formation of human umbilical vein endothelial cells. Further investigation revealed that IL-1β-induced RUNX1 expression might be mediated via the p38 mitogen-activated protein kinase (MAPK) signaling molecule for the expression of these invasion- and angiogenic-related molecules. Together with an inhibitor of p38 MAPK (SB203580) could decrease RUNX1 mRNA expression. Thus, RUNX1 may be one of the putative molecular targeted therapies against glioma metastasis and angiogenesis through the activation of p38 MAPK signaling pathway.
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Keywords {🔍}

pubmed, article, google, scholar, cas, runx, cell, invasion, cells, cancer, matrix, central, human, expression, glioma, angiogenesis, glioblastoma, migration, gene, dois, factor, tumor, metalloproteinase, mmp, role, protein, progression, growth, mapk, signaling, oncogene, metalloproteinases, biol, thailand, research, transcription, proliferation, kinase, access, promotes, oncol, res, brain, doisjonc, privacy, cookies, content, molecular, pathway, sangpairoj,

Topics {✒️}

month download article/chapter il-1β-induced runx1 expression transforming growth factor-beta growth factor-binding protein-3 dose-dependent cross-talk hypoxia-inducible-factor pathway 10 ng/ml stimulated translocation mmtv-pymt transgenic mice real-time quantitative pcr transcription factors runx1/aml1 u-87 mg cells runx1-evi1 fusion gene hypoxia-selected glioblastoma cells acute myeloid leukemia runx1 transcription factor persistent interleukin-1beta signaling phorbol ester-induced regulation central nervous system glioma cell motility runx2/cbfa1 dynamically associate full article pdf map-ing glioma invasion kant sangpairoj article sangpairoj inflammatory cytokine modulation cell-type specific regulation p38 mapk pathway inhibits tumor growth runx1 regulates migration nuclear factor kappa promoter-specific manner privacy choices/manage cookies vitro inhibits migration author information authors molecular neurobiology aims runx1 promotes angiogenesis tumor-related angiogenesis angiogenic-related molecules runx protein signaling national research council article cellular glioblastoma secretome suggest il-1β hematopoietic stem cells matrix metalloproteinase expression related subjects service support category human glial cells acetylcholinesterase gene expression check access

Questions {❓}

Vincenti MP, Brinckerhoff CE (2007) Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you?

Schema {🗺️}

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