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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
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We are analyzing https://link.springer.com/article/10.1007/s10565-025-10012-y.

Title:
Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment | Cell Biology and Toxicology
Description:
Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, eosinophils and basophils, participate in the generation, development, invasion and metastasis of tumors by producing different cytokines and interacting with other cell types, and play a pro-tumor or anti-tumor role in regulating tumor immunity. Due to the complexity of cell types in the tumor microenvironment and the unknown process of tumor development and metastasis, cancer treatment to achieve better survival status remains challenging. In this article, we summarize the effects of myeloid cells in tumor microenvironment on tumor immunity, cancer migration, and crosstalk with metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism), which will help to further study the tumor microenvironment and seek targeted therapeutic strategies for patients. Graphical abstract Myeloid cells in the tumor microenvironment exhibit diverse biological functions, influencing tumor initiation and progression. Myeloid cells are involved in tumor immunity and metastasis processes, interacting with other immune cell types to affect the tumor immune response. The crosstalk between glucose metabolism, lipid metabolism, amino acid metabolism, and myeloid cells impacts tumor immunity and metastasis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, cells, cancer, article, tumor, google, scholar, cas, macrophages, central, metastasis, cell, metabolism, wang, immune, tams, promote, zhang, growth, liu, microenvironment, acid, chen, myeloid, mdscs, tme, neutrophils, suppressor, immunity, antitumor, tumorassociated, httpsdoiorgs, function, myeloidderived, development, promotes, macrophage, yang, dendritic, res, eosinophils, promoting, immunol, progression, studies, huang, glucose, angiogenesis, role, human,

Topics {✒️}

jak2/stat3/mir-506-3p/foxq1 axis anti-pd-1/pd-l1 immunotherapy erk/p38/src signaling pathway /mavs/traf1/nf-κb pathway fas ligand/fas pathway gm-csf-pd-l1 pathway gm-csf-irf5 signaling axis granulocyte colony-stimulating factor ccl22-secreting cd11b+cd11c+ cells macrophage colony-stimulating factor express anti-tumor il-12p70 il-6r/stat3 signaling pathway transforming growth factor-beta erk/p38/src signaling platelet-derived growth factor cell-mediated immune responses hypoxia-inducible factor-1α initiate anti-tumor responses article download pdf hif-1α-dependent manner retinoic acid-inducible gene spib/spi1-facilitated interplay myeloid-derived suppressor cells myeloid-derived suppressor cells producing large amounts suppress anti-tumor immunity huanming yang & kui wu tumor-derived extracellular vesicles promoting anti-tumorigenic responses srebp1-dependent metabolic fitness /mavs/nf-κb pathway cathepsin g-induced aggregation circ-0034880-rich extracellular vesicles cell-mediated tumor suppression wnt5a-induced m2 polarization cell anti-tumor responses jak2/stat3/snail pathway macrophage-directed cancer immunotherapy tryptophan-derived microbial metabolites human tumor micro-environment neutrophils express pd-l1 triple-negative breast cancer β1-integrin mediated interactions ppar-γ-dependent induction myeloid cell-targeted therapies cell-derived interferon-γ semi-essential amino acid exert anti-tumor effects hematopoietic stem cells tumor-induced oxidative neutrophils

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment
         description:Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, eosinophils and basophils, participate in the generation, development, invasion and metastasis of tumors by producing different cytokines and interacting with other cell types, and play a pro-tumor or anti-tumor role in regulating tumor immunity. Due to the complexity of cell types in the tumor microenvironment and the unknown process of tumor development and metastasis, cancer treatment to achieve better survival status remains challenging. In this article, we summarize the effects of myeloid cells in tumor microenvironment on tumor immunity, cancer migration, and crosstalk with metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism), which will help to further study the tumor microenvironment and seek targeted therapeutic strategies for patients. Myeloid cells in the tumor microenvironment exhibit diverse biological functions, influencing tumor initiation and progression. Myeloid cells are involved in tumor immunity and metastasis processes, interacting with other immune cell types to affect the tumor immune response. The crosstalk between glucose metabolism, lipid metabolism, amino acid metabolism, and myeloid cells impacts tumor immunity and metastasis.
         datePublished:2025-03-25T00:00:00Z
         dateModified:2025-03-25T00:00:00Z
         pageStart:1
         pageEnd:22
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s10565-025-10012-y
         keywords:
            Tumor microenvironment
            Myeloid cells
            Cancer metastasis
            Glucose metabolism
            Amino acid metabolism
            Cell Biology
            Pharmacology/Toxicology
            Biochemistry
            general
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                     name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
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                        name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                        type:PostalAddress
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               name:Ying Song
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                        name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                        type:PostalAddress
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                        type:PostalAddress
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                     name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
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                        type:PostalAddress
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                        name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                        type:PostalAddress
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                     name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                     address:
                        name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                        type:PostalAddress
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                     name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
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                        name:BGI Genomics, Harbin, China
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                     address:
                        name:Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen, China
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ScholarlyArticle:
      headline:Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment
      description:Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, eosinophils and basophils, participate in the generation, development, invasion and metastasis of tumors by producing different cytokines and interacting with other cell types, and play a pro-tumor or anti-tumor role in regulating tumor immunity. Due to the complexity of cell types in the tumor microenvironment and the unknown process of tumor development and metastasis, cancer treatment to achieve better survival status remains challenging. In this article, we summarize the effects of myeloid cells in tumor microenvironment on tumor immunity, cancer migration, and crosstalk with metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism), which will help to further study the tumor microenvironment and seek targeted therapeutic strategies for patients. Myeloid cells in the tumor microenvironment exhibit diverse biological functions, influencing tumor initiation and progression. Myeloid cells are involved in tumor immunity and metastasis processes, interacting with other immune cell types to affect the tumor immune response. The crosstalk between glucose metabolism, lipid metabolism, amino acid metabolism, and myeloid cells impacts tumor immunity and metastasis.
      datePublished:2025-03-25T00:00:00Z
      dateModified:2025-03-25T00:00:00Z
      pageStart:1
      pageEnd:22
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s10565-025-10012-y
      keywords:
         Tumor microenvironment
         Myeloid cells
         Cancer metastasis
         Glucose metabolism
         Amino acid metabolism
         Cell Biology
         Pharmacology/Toxicology
         Biochemistry
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10565-025-10012-y/MediaObjects/10565_2025_10012_Figa_HTML.jpg
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10565-025-10012-y/MediaObjects/10565_2025_10012_Fig3_HTML.png
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         name:Springer Netherlands
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            name:Chenbo Zhang
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                  name:Zhejiang University of Technology
                  address:
                     name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                  address:
                     name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                     type:PostalAddress
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                  name:Zhejiang University of Technology
                  address:
                     name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                     type:PostalAddress
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            name:Huanming Yang
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                  name:Zhejiang University of Technology
                  address:
                     name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                  address:
                     name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                  address:
                     name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
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            name:Kui Wu
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                  address:
                     name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                  address:
                     name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
                  address:
                     name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:BGI Genomics
                  address:
                     name:BGI Genomics, Harbin, China
                     type:PostalAddress
                  type:Organization
                  name:BGI Research
                  address:
                     name:Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen, China
                     type:PostalAddress
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      name:Springer Netherlands
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Zhejiang University of Technology
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         type:PostalAddress
      name:Zhejiang University of Technology
      address:
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         type:PostalAddress
      name:Zhejiang University of Technology
      address:
         name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
         type:PostalAddress
      name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
      address:
         name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
         type:PostalAddress
      name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
      address:
         name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University of Technology
      address:
         name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
         type:PostalAddress
      name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
      address:
         name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
         type:PostalAddress
      name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
      address:
         name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
         type:PostalAddress
      name:BGI Genomics
      address:
         name:BGI Genomics, Harbin, China
         type:PostalAddress
      name:BGI Research
      address:
         name:Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen, China
         type:PostalAddress
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Person:
      name:Chenbo Zhang
      affiliation:
            name:Zhejiang University of Technology
            address:
               name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
            address:
               name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Ying Song
      affiliation:
            name:Zhejiang University of Technology
            address:
               name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Huanming Yang
      affiliation:
            name:Zhejiang University of Technology
            address:
               name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
            address:
               name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
            address:
               name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kui Wu
      affiliation:
            name:Zhejiang University of Technology
            address:
               name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
            address:
               name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
            address:
               name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:BGI Genomics
            address:
               name:BGI Genomics, Harbin, China
               type:PostalAddress
            type:Organization
            name:BGI Research
            address:
               name:Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
      name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
      name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
      name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
      name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
      name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
      name:College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
      name:HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
      name:Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China
      name:BGI Genomics, Harbin, China
      name:Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen, China

External Links {🔗}(738)

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