We are analyzing https://link.springer.com/article/10.1007/s10557-010-6271-7.

Title:
Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats | Cardiovascular Drugs and Therapy
Description:
Cardiovascular risk is closely associated with insulin resistance and type 2 diabetes. Therapy based on the actions of GLP-1 is currently seen as a novel approach to treat this disease. The aims of this study was therefore to use an animal model to determine whether (i) pre-treatment of obese, insulin resistant but pre-diabetic rats with a DPP4 inhibitor, PFK275-055, could protect the heart from ischaemia/reperfusion injury and (ii) the possible mechanisms involved in such protection. Obese, pre-diabetic rats (DIO) were treated for 4 weeks with 10 mg/kg/day of the DPP4 inhibitor PFK275-055. Ex vivo perfusion was used to subject hearts to ischaemia/reperfusion to determine infarct size, functional recovery and post-ischaemic activation of proteins associated with cardiac protection. Adult ventricular cardiomyocytes were isolated to determine insulin sensitivity. Other assessments included body weight, intra-peritoneal fat weight, insulin and GLP-1 levels as well as histological evaluation of the pancreata. Results showed that DIO animals had higher body mass and intra-peritoneal fat mass than chow-fed animals. They presented with elevated plasma insulin levels and lower GLP-1 levels. Treatment with the DPP4 inhibitor resulted in smaller infarct size development in hearts from DIO rats after ischaemia/reperfusion accompanied by activation of cardioprotective kinases. GLP-1 levels were elevated and plasma insulin levels lower after treatment. In addition, the beta-cell to alpha-cell ratio of the pancreas was improved. We conclude that treatment with PFK275-055 for 4 weeks protected the heart against ischaemia/reperfusion injury, elevated GLP-1 levels and improved metabolic control in obese, pre-diabetic rats.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Fitness & Wellness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, google, scholar, pubmed, cas, diabetes, glucagonlike, insulin, peptide, cardiovascular, dpp, inhibitor, rats, huisamen, type, glp, heart, lochner, injury, obese, levels, access, peptidase, inhibitors, privacy, cookies, content, protection, infarct, hearts, prediabetic, amanda, ischaemiareperfusion, dipeptidyl, cardiovasc, publish, search, drugs, pretreatment, barbara, marais, treatment, effects, med, incretin, ther, glucose, role, basic, res,

Topics {✒️}

month download article/chapter erna marais & amanda lochner diet-induced endothelial dysfunction intra-peritoneal fat weight intra-peritoneal fat mass dipeptidyl peptidase-4 inhibitors streptozotocin-induced diabetic rats ncep-defined metabolic syndrome article cardiovascular drugs pre-diabetic rats published full article pdf signalling pathways activated dpp4 inhibitor resulted privacy choices/manage cookies reduced incretin effect dpp4 inhibitor pfk275-055 improved glucose metabolism ischaemia/reperfusion injury ischaemia-reperfusion injury adult ventricular cardiomyocytes alpha-cell ratio related subjects drucker dj total body weight higher body mass intra-abdominal adiposity ischaemic/reperfusion injury left ventricular dysfunction diab obes metab ischemia/reperfusion injury ischaemia/reperfusion accompanied pre-diabetic rats cardiovasc drugs ther article huisamen determine insulin sensitivity european economic area 10 mg/kg/day percutaneous coronary intervention genes regulating autophagy mitochondrial fission/fusion nondiabetic european men 3t3-l1 adipocytes curr hypertens rep amino]acetyl]-2-cyano folin phenol reagent deacon cf pickavance lc curr enzyme inhib basic res cardiol conditions privacy policy

Questions {❓}

What do we know about the secretion and degradation of incretin hormones?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats
         description:Cardiovascular risk is closely associated with insulin resistance and type 2 diabetes. Therapy based on the actions of GLP-1 is currently seen as a novel approach to treat this disease. The aims of this study was therefore to use an animal model to determine whether (i) pre-treatment of obese, insulin resistant but pre-diabetic rats with a DPP4 inhibitor, PFK275-055, could protect the heart from ischaemia/reperfusion injury and (ii) the possible mechanisms involved in such protection. Obese, pre-diabetic rats (DIO) were treated for 4 weeks with 10 mg/kg/day of the DPP4 inhibitor PFK275-055. Ex vivo perfusion was used to subject hearts to ischaemia/reperfusion to determine infarct size, functional recovery and post-ischaemic activation of proteins associated with cardiac protection. Adult ventricular cardiomyocytes were isolated to determine insulin sensitivity. Other assessments included body weight, intra-peritoneal fat weight, insulin and GLP-1 levels as well as histological evaluation of the pancreata. Results showed that DIO animals had higher body mass and intra-peritoneal fat mass than chow-fed animals. They presented with elevated plasma insulin levels and lower GLP-1 levels. Treatment with the DPP4 inhibitor resulted in smaller infarct size development in hearts from DIO rats after ischaemia/reperfusion accompanied by activation of cardioprotective kinases. GLP-1 levels were elevated and plasma insulin levels lower after treatment. In addition, the beta-cell to alpha-cell ratio of the pancreas was improved. We conclude that treatment with PFK275-055 for 4 weeks protected the heart against ischaemia/reperfusion injury, elevated GLP-1 levels and improved metabolic control in obese, pre-diabetic rats.
         datePublished:2010-11-19T00:00:00Z
         dateModified:2010-11-19T00:00:00Z
         pageStart:13
         pageEnd:20
         sameAs:https://doi.org/10.1007/s10557-010-6271-7
         keywords:
            DPP4 inhibitor
            Heart
            Insulin resistance
            Obesity
            Cardiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig5_HTML.gif
         isPartOf:
            name:Cardiovascular Drugs and Therapy
            issn:
               1573-7241
               0920-3206
            volumeNumber:25
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Barbara Huisamen
               affiliation:
                     name:MRC Cape Heart Centre
                     address:
                        name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
                        type:PostalAddress
                     type:Organization
                     name:University of Stellenbosch
                     address:
                        name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Amanda Genis
               affiliation:
                     name:University of Stellenbosch
                     address:
                        name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Erna Marais
               affiliation:
                     name:University of Stellenbosch
                     address:
                        name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amanda Lochner
               affiliation:
                     name:MRC Cape Heart Centre
                     address:
                        name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
                        type:PostalAddress
                     type:Organization
                     name:University of Stellenbosch
                     address:
                        name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pre-treatment with a DPP-4 Inhibitor is Infarct Sparing in Hearts from Obese, Pre-diabetic Rats
      description:Cardiovascular risk is closely associated with insulin resistance and type 2 diabetes. Therapy based on the actions of GLP-1 is currently seen as a novel approach to treat this disease. The aims of this study was therefore to use an animal model to determine whether (i) pre-treatment of obese, insulin resistant but pre-diabetic rats with a DPP4 inhibitor, PFK275-055, could protect the heart from ischaemia/reperfusion injury and (ii) the possible mechanisms involved in such protection. Obese, pre-diabetic rats (DIO) were treated for 4 weeks with 10 mg/kg/day of the DPP4 inhibitor PFK275-055. Ex vivo perfusion was used to subject hearts to ischaemia/reperfusion to determine infarct size, functional recovery and post-ischaemic activation of proteins associated with cardiac protection. Adult ventricular cardiomyocytes were isolated to determine insulin sensitivity. Other assessments included body weight, intra-peritoneal fat weight, insulin and GLP-1 levels as well as histological evaluation of the pancreata. Results showed that DIO animals had higher body mass and intra-peritoneal fat mass than chow-fed animals. They presented with elevated plasma insulin levels and lower GLP-1 levels. Treatment with the DPP4 inhibitor resulted in smaller infarct size development in hearts from DIO rats after ischaemia/reperfusion accompanied by activation of cardioprotective kinases. GLP-1 levels were elevated and plasma insulin levels lower after treatment. In addition, the beta-cell to alpha-cell ratio of the pancreas was improved. We conclude that treatment with PFK275-055 for 4 weeks protected the heart against ischaemia/reperfusion injury, elevated GLP-1 levels and improved metabolic control in obese, pre-diabetic rats.
      datePublished:2010-11-19T00:00:00Z
      dateModified:2010-11-19T00:00:00Z
      pageStart:13
      pageEnd:20
      sameAs:https://doi.org/10.1007/s10557-010-6271-7
      keywords:
         DPP4 inhibitor
         Heart
         Insulin resistance
         Obesity
         Cardiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10557-010-6271-7/MediaObjects/10557_2010_6271_Fig5_HTML.gif
      isPartOf:
         name:Cardiovascular Drugs and Therapy
         issn:
            1573-7241
            0920-3206
         volumeNumber:25
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Barbara Huisamen
            affiliation:
                  name:MRC Cape Heart Centre
                  address:
                     name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
                     type:PostalAddress
                  type:Organization
                  name:University of Stellenbosch
                  address:
                     name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Amanda Genis
            affiliation:
                  name:University of Stellenbosch
                  address:
                     name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Erna Marais
            affiliation:
                  name:University of Stellenbosch
                  address:
                     name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amanda Lochner
            affiliation:
                  name:MRC Cape Heart Centre
                  address:
                     name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
                     type:PostalAddress
                  type:Organization
                  name:University of Stellenbosch
                  address:
                     name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cardiovascular Drugs and Therapy
      issn:
         1573-7241
         0920-3206
      volumeNumber:25
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:MRC Cape Heart Centre
      address:
         name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
         type:PostalAddress
      name:University of Stellenbosch
      address:
         name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
         type:PostalAddress
      name:University of Stellenbosch
      address:
         name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
         type:PostalAddress
      name:University of Stellenbosch
      address:
         name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
         type:PostalAddress
      name:MRC Cape Heart Centre
      address:
         name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
         type:PostalAddress
      name:University of Stellenbosch
      address:
         name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Barbara Huisamen
      affiliation:
            name:MRC Cape Heart Centre
            address:
               name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
               type:PostalAddress
            type:Organization
            name:University of Stellenbosch
            address:
               name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Amanda Genis
      affiliation:
            name:University of Stellenbosch
            address:
               name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
               type:PostalAddress
            type:Organization
      name:Erna Marais
      affiliation:
            name:University of Stellenbosch
            address:
               name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
               type:PostalAddress
            type:Organization
      name:Amanda Lochner
      affiliation:
            name:MRC Cape Heart Centre
            address:
               name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
               type:PostalAddress
            type:Organization
            name:University of Stellenbosch
            address:
               name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
               type:PostalAddress
            type:Organization
PostalAddress:
      name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
      name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
      name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
      name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
      name:MRC Cape Heart Centre, Cape Town, Republic of South Africa
      name:Department of Biomedical Sciences, Division Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(116)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.82s.

LINK . SPRINGER . COM {}