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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10555-024-10225-3.

Title:
KIF18A inhibition: the next big player in the search for cancer therapeutics | Cancer and Metastasis Reviews
Description:
Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to regulate critical cellular processes such as chromosome movement and microtubule dynamics. KIF18A plays a vital role in controlling microtubule length, which is crucial for maintaining proper cell function and division. Notably, increased expression levels of KIF18A have been observed in various types of cancer, indicating its potential involvement in tumour progression. Although preclinical studies have demonstrated that KIF18A is not essential for normal somatic cell division, it appears to be crucial for the survival and division of cancer cells, particularly those exhibiting chromosomal instability. This dependency makes KIF18A a promising target for developing new therapeutic strategies aimed at treating chromosomally unstable cancers. This review delves into the structural and functional aspects of KIF18A, and its role in cancer development, and evaluates current and emerging approaches to targeting KIF18A with innovative cancer treatments.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, kifa, kinesin, cancer, cell, biology, microtubule, nature, journal, research, molecular, proteins, spindle, httpsdoiorgs, chromosome, mitotic, australia, protein, motor, expression, checkpoint, chen, vic, current, zhang, manuscript, cells, science, regulation, search, reviews, dynamics, superfamily, httpsdoiorgjcub, kinetochore, assembly, proliferation, liu, oncology, breast, supported, privacy, essential, cookies, function,

Topics {✒️}

month download article/chapter dynein superfamily proteins kinesin family member-18a kinesin-binding protein remodels full article pdf exhibiting chromosomal instability molecular motor proteins kinesin motor proteins comprehensive pan-cancer analysis chromosomally unstable cancers spindle assembly checkpoint peter maccallum foundation sir peter maccallum award number w81xwh2110496 cell cycle privacy choices/manage cookies microtubule minus-end regulation mitotic checkpoint inhibition mitotic kinesin kif18a joanne boag increased tumor stage mitotic vulnerability enriched kinesin 18a expression differentiated animal cells metastasis reviews aims tumour progression lung adenocarcinoma cells meiotic spindle integrity kinesin superfamily protein cure cancer australia article cancer breast cancer research akt signaling pathway ovarian cancer multitasking kinesin-8 motor cytoskeletal mechanics 5point foundation fellowship spindle length regulation increased expression levels kif18a promotes head main manuscript text nature cell biology holds exclusive rights innovative cancer treatments transl cancer res standardized kinesin nomenclature kinetochore kinesin cenp prevent microtubule binding article number 3 biophysical research communications

Schema {🗺️}

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         headline:KIF18A inhibition: the next big player in the search for cancer therapeutics
         description:Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to regulate critical cellular processes such as chromosome movement and microtubule dynamics. KIF18A plays a vital role in controlling microtubule length, which is crucial for maintaining proper cell function and division. Notably, increased expression levels of KIF18A have been observed in various types of cancer, indicating its potential involvement in tumour progression. Although preclinical studies have demonstrated that KIF18A is not essential for normal somatic cell division, it appears to be crucial for the survival and division of cancer cells, particularly those exhibiting chromosomal instability. This dependency makes KIF18A a promising target for developing new therapeutic strategies aimed at treating chromosomally unstable cancers. This review delves into the structural and functional aspects of KIF18A, and its role in cancer development, and evaluates current and emerging approaches to targeting KIF18A with innovative cancer treatments.
         datePublished:2024-11-24T00:00:00Z
         dateModified:2024-11-24T00:00:00Z
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            Chromosomal instability
            Cancer
            Drug target
            Cancer Research
            Oncology
            Biomedicine
            general
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                        name:The Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Grattan St, Parkville, Australia
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      headline:KIF18A inhibition: the next big player in the search for cancer therapeutics
      description:Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to regulate critical cellular processes such as chromosome movement and microtubule dynamics. KIF18A plays a vital role in controlling microtubule length, which is crucial for maintaining proper cell function and division. Notably, increased expression levels of KIF18A have been observed in various types of cancer, indicating its potential involvement in tumour progression. Although preclinical studies have demonstrated that KIF18A is not essential for normal somatic cell division, it appears to be crucial for the survival and division of cancer cells, particularly those exhibiting chromosomal instability. This dependency makes KIF18A a promising target for developing new therapeutic strategies aimed at treating chromosomally unstable cancers. This review delves into the structural and functional aspects of KIF18A, and its role in cancer development, and evaluates current and emerging approaches to targeting KIF18A with innovative cancer treatments.
      datePublished:2024-11-24T00:00:00Z
      dateModified:2024-11-24T00:00:00Z
      pageStart:1
      pageEnd:12
      sameAs:https://doi.org/10.1007/s10555-024-10225-3
      keywords:
         Kinesin-like protein KIF18A
         Chromosomal instability
         Cancer
         Drug target
         Cancer Research
         Oncology
         Biomedicine
         general
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                  address:
                     name:STEM College, RMIT University, Bundoora, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard Foitzik
            affiliation:
                  name:Oncology One Pty Ltd
                  address:
                     name:Oncology One Pty Ltd, Melbourne, Australia
                     type:PostalAddress
                  type:Organization
                  name:Inosi Therapeutics Pty Ltd
                  address:
                     name:Inosi Therapeutics Pty Ltd, Melbourne, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joanne Boag
            affiliation:
                  name:Oncology One Pty Ltd
                  address:
                     name:Oncology One Pty Ltd, Melbourne, Australia
                     type:PostalAddress
                  type:Organization
                  name:The Walter and Eliza Hall Institute of Medical Research
                  address:
                     name:The Walter and Eliza Hall Institute of Medical Research, Bundoora, Australia
                     type:PostalAddress
                  type:Organization
                  name:Ternarx Pty Ltd
                  address:
                     name:Ternarx Pty Ltd, Bundoora, Australia
                     type:PostalAddress
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            type:Person
            name:Kylie L. Gorringe
            affiliation:
                  name:Peter MacCallum Cancer Centre
                  address:
                     name:Peter MacCallum Cancer Centre, Melbourne, Australia
                     type:PostalAddress
                  type:Organization
                  name:Sir Peter MacCallum, The University of Melbourne, Grattan St
                  address:
                     name:Department of Oncology, Sir Peter MacCallum, The University of Melbourne, Grattan St, Parkville, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jessica K. Holien
            affiliation:
                  name:STEM College, RMIT University
                  address:
                     name:STEM College, RMIT University, Bundoora, Australia
                     type:PostalAddress
                  type:Organization
                  name:The University of Melbourne, Grattan St
                  address:
                     name:The Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Grattan St, Parkville, Australia
                     type:PostalAddress
                  type:Organization
                  name:St Vincent’s Institute of Medical Research
                  address:
                     name:St Vincent’s Institute of Medical Research, Fitzroy, Australia
                     type:PostalAddress
                  type:Organization
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      address:
         name:STEM College, RMIT University, Bundoora, Australia
         type:PostalAddress
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      address:
         name:Oncology One Pty Ltd, Melbourne, Australia
         type:PostalAddress
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      address:
         name:Inosi Therapeutics Pty Ltd, Melbourne, Australia
         type:PostalAddress
      name:Oncology One Pty Ltd
      address:
         name:Oncology One Pty Ltd, Melbourne, Australia
         type:PostalAddress
      name:The Walter and Eliza Hall Institute of Medical Research
      address:
         name:The Walter and Eliza Hall Institute of Medical Research, Bundoora, Australia
         type:PostalAddress
      name:Ternarx Pty Ltd
      address:
         name:Ternarx Pty Ltd, Bundoora, Australia
         type:PostalAddress
      name:Peter MacCallum Cancer Centre
      address:
         name:Peter MacCallum Cancer Centre, Melbourne, Australia
         type:PostalAddress
      name:Sir Peter MacCallum, The University of Melbourne, Grattan St
      address:
         name:Department of Oncology, Sir Peter MacCallum, The University of Melbourne, Grattan St, Parkville, Australia
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      name:STEM College, RMIT University
      address:
         name:STEM College, RMIT University, Bundoora, Australia
         type:PostalAddress
      name:The University of Melbourne, Grattan St
      address:
         name:The Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Grattan St, Parkville, Australia
         type:PostalAddress
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      address:
         name:St Vincent’s Institute of Medical Research, Fitzroy, Australia
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      affiliation:
            name:STEM College, RMIT University
            address:
               name:STEM College, RMIT University, Bundoora, Australia
               type:PostalAddress
            type:Organization
      name:Sarah Eastwood
      affiliation:
            name:STEM College, RMIT University
            address:
               name:STEM College, RMIT University, Bundoora, Australia
               type:PostalAddress
            type:Organization
      name:Courtney Pilcher
      affiliation:
            name:STEM College, RMIT University
            address:
               name:STEM College, RMIT University, Bundoora, Australia
               type:PostalAddress
            type:Organization
      name:Jia Q. Truong
      affiliation:
            name:STEM College, RMIT University
            address:
               name:STEM College, RMIT University, Bundoora, Australia
               type:PostalAddress
            type:Organization
      name:Richard Foitzik
      affiliation:
            name:Oncology One Pty Ltd
            address:
               name:Oncology One Pty Ltd, Melbourne, Australia
               type:PostalAddress
            type:Organization
            name:Inosi Therapeutics Pty Ltd
            address:
               name:Inosi Therapeutics Pty Ltd, Melbourne, Australia
               type:PostalAddress
            type:Organization
      name:Joanne Boag
      affiliation:
            name:Oncology One Pty Ltd
            address:
               name:Oncology One Pty Ltd, Melbourne, Australia
               type:PostalAddress
            type:Organization
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:The Walter and Eliza Hall Institute of Medical Research, Bundoora, Australia
               type:PostalAddress
            type:Organization
            name:Ternarx Pty Ltd
            address:
               name:Ternarx Pty Ltd, Bundoora, Australia
               type:PostalAddress
            type:Organization
      name:Kylie L. Gorringe
      affiliation:
            name:Peter MacCallum Cancer Centre
            address:
               name:Peter MacCallum Cancer Centre, Melbourne, Australia
               type:PostalAddress
            type:Organization
            name:Sir Peter MacCallum, The University of Melbourne, Grattan St
            address:
               name:Department of Oncology, Sir Peter MacCallum, The University of Melbourne, Grattan St, Parkville, Australia
               type:PostalAddress
            type:Organization
      name:Jessica K. Holien
      affiliation:
            name:STEM College, RMIT University
            address:
               name:STEM College, RMIT University, Bundoora, Australia
               type:PostalAddress
            type:Organization
            name:The University of Melbourne, Grattan St
            address:
               name:The Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Grattan St, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:St Vincent’s Institute of Medical Research
            address:
               name:St Vincent’s Institute of Medical Research, Fitzroy, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:STEM College, RMIT University, Bundoora, Australia
      name:STEM College, RMIT University, Bundoora, Australia
      name:STEM College, RMIT University, Bundoora, Australia
      name:STEM College, RMIT University, Bundoora, Australia
      name:Oncology One Pty Ltd, Melbourne, Australia
      name:Inosi Therapeutics Pty Ltd, Melbourne, Australia
      name:Oncology One Pty Ltd, Melbourne, Australia
      name:The Walter and Eliza Hall Institute of Medical Research, Bundoora, Australia
      name:Ternarx Pty Ltd, Bundoora, Australia
      name:Peter MacCallum Cancer Centre, Melbourne, Australia
      name:Department of Oncology, Sir Peter MacCallum, The University of Melbourne, Grattan St, Parkville, Australia
      name:STEM College, RMIT University, Bundoora, Australia
      name:The Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Grattan St, Parkville, Australia
      name:St Vincent’s Institute of Medical Research, Fitzroy, Australia
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External Links {🔗}(348)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Foundation
  • Prism.js

CDN Services {📦}

  • Crossref

4.17s.