We are analyzing https://link.springer.com/article/10.1007/s10555-024-10221-7.

Title:
Vaping and tumor metastasis: current insights and progress | Cancer and Metastasis Reviews
Description:
Tumor metastasis is the primary cause of cancer-related mortality and remains a major hurdle in cancer treatment. Traditional cigarette smoking has been extensively studied for its role in promoting metastasis. However, the impact of e-cigarette (e-cig) on cancer metastasis is not well understood despite their increasing popularity as a supposedly safer alternative. This mini review synthesizes current literature on the effects of e-cig on cancer metastasis, focusing on the processes of dissemination, dormancy, and colonization. It also incorporates recent findings from our laboratory regarding the role of e-cig in tumor progression. E-cig exposure enhances metastatic potential through various mechanisms: it induces epithelial-mesenchymal transition (EMT), increasing cell migratory and invasive capabilities; promotes lymphangiogenesis, aiding tumor cell spread; and alters the pre-metastatic niche to support dormant tumor cells, enhancing their reactivation and colonization. Furthermore, e-cig induce significant epigenetic changes, such as DNA methylation and histone modifications, which regulate genes involved in metastasis. Our data suggest that e-cig upregulate histone demethylases like KDM6B in macrophages, impacting the TME and promoting metastasis. These findings underscore the need for further research to understand the long-term health implications of e-cig use and inform public health policies to reduce e-cig use. Graphical abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

month download article/chapter flavored e-cigarette e-liquids high-plasticity cell state induces epithelial-mesenchymal transition macrophage-tumor cells crosstalk aryl hydrocarbon receptor generating pre-metastatic niche flavored e-cigarette liquids ceramic wick-based technology e-cigarette flavoring chemicals onco-suppressor dab2ip expression kras-mutant lung cancer e-cigarette vaping surge mir-155-5p/ndfip1 axis epithelial-mesenchymal transition distinct immune microenvironment histone methyltransferase ezh2 nod-scid-gamma mice solid tumor microenvironment immunosuppressive tumor microenvironment high school students central neural control full article pdf bronchial epithelial cells squamous cell carcinoma pre-metastatic niche e-cigarette liquids long-term health implications jama network open post-translational modifications related subjects reduce e-cig cancer-related mortality lung cancer cells disseminated tumor cells immune-mediated pruning oral cavity cancer privacy choices/manage cookies human breast cancer nature cell biology breast cancer metastasis tumor-immune ecosystem cigarette smoke affects e-cigarette users nature reviews cancer high-income countries extensive electronic cigarette lung cancer metastasis nicotine vaping products reducing combustible cigarette

Questions {❓}

Are e-cigarette users at an increased risk of bladder and lung cancer?
The effect of hypoxia and hypoxia-associated pathways in the regulation of antitumor response: Friends or foes?
Tissue regeneration: Reserve or reverse?

Schema {🗺️}

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