We are analyzing https://link.springer.com/article/10.1007/s10555-010-9235-2.

Title:
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals | Cancer and Metastasis Reviews
Description:
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of about 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. How our diet can prevent cancer is the focus of this review. Specifically, we will discuss how nutraceuticals, such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, γ-tocotrienol, and zerumbone, derived from spices, legumes, fruits, nuts, and vegetables, can modulate inflammatory pathways and thus affect the survival, proliferation, invasion, angiogenesis, and metastasis of the tumor. Various cell signaling pathways that are modulated by these agents will also be discussed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

google, scholar, cas, pubmed, article, cancer, cells, journal, human, cell, apoptosis, research, expression, inhibits, aggarwal, activation, molecular, inhibition, growth, invasion, tumor, kim, breast, angiogenesis, nuclear, pathway, gene, lee, signaling, nfkappab, prostate, proliferation, suppression, international, metastasis, acid, carcinoma, kinase, induces, matrix, wang, chen, liu, lung, factor, biological, chemistry, carcinogenesis, prevention, nutrition,

Topics {✒️}

12-o-tetradecanoylphorbol-13-acetate-induced nf-kappab activation wnt/egfr/nf-kappab-signaling pathways wnt/beta-catenin signaling pathway nf-kappab-regulated gene expression suppressing nf-kappab-regulated antiapoptotic tumour necrosis factor-alpha tnf-alpha-induced icam-1 expression c-jun n-terminal kinase inducible nuclear factor-kappa month download article/chapter nuclear factor-kappab pathway ultraviolet b-mediated activation nuclear factor-kappabalpha kinase targeting nuclear factor-kappa transforming growth factor-alpha inducible nf-kappab activation guggulsterone inhibits nf-kappab cas google scholar mitogen-activated protein kinases nf-kappab signaling pathway growth factor-stimulated proliferation transcription factor nf-kappa regulating nuclear factor-kappa nonpeptidic small-molecule antagonists inhibit tumour-specific angiogenesis e-cadherin/catenin complexes prostaglandin synthase/cyclooxygenase homologue anti-apoptotic gene products inhibiting nf-kappab activation c-rel transcription factor nik/ikk signalling complex protecting rb-e2f-1 complex nf-kappab/ap-1-dependent inhibiting cell–ecm adhesion enhances trail-induced apoptosis key cell-cycle regulators radiation-induced g1 arrest interleukin-6-inducible stat3 activation nuclear factor-kappab nuclear factor kappab zerumbone abolishes nf-kappab inhibits nuclear factor erk1-dependent signaling pathway hormone-refractory prostate cancer alpha/ikk signaling pathways prb-mediated growth suppression nuclear factor-kappa hot chili pepper reactive oxygen species increases e-cadherin production

Questions {❓}

Angiogenesis: An organizing principle for drug discovery?
Capsaicin in hot chili pepper: Carcinogen, co-carcinogen or anticarcinogen?
Inflammation and cancer: How friendly is the relationship for cancer patients?
Is there a benefit from lycopene supplementation in men with prostate cancer?
Nutraceuticals: Poised for a healthy slice of the healthcare market?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
         description:Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of about 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. How our diet can prevent cancer is the focus of this review. Specifically, we will discuss how nutraceuticals, such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, γ-tocotrienol, and zerumbone, derived from spices, legumes, fruits, nuts, and vegetables, can modulate inflammatory pathways and thus affect the survival, proliferation, invasion, angiogenesis, and metastasis of the tumor. Various cell signaling pathways that are modulated by these agents will also be discussed.
         datePublished:2010-08-25T00:00:00Z
         dateModified:2010-08-25T00:00:00Z
         pageStart:405
         pageEnd:434
         sameAs:https://doi.org/10.1007/s10555-010-9235-2
         keywords:
            Inflammation
            NF-κB
            Nutraceuticals
            Therapeutics
            Tumorigenesis
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3a_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3b_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3c_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig4_HTML.gif
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Subash C. Gupta
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ji Hye Kim
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sahdeo Prasad
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bharat B. Aggarwal
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
      description:Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of about 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. How our diet can prevent cancer is the focus of this review. Specifically, we will discuss how nutraceuticals, such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, γ-tocotrienol, and zerumbone, derived from spices, legumes, fruits, nuts, and vegetables, can modulate inflammatory pathways and thus affect the survival, proliferation, invasion, angiogenesis, and metastasis of the tumor. Various cell signaling pathways that are modulated by these agents will also be discussed.
      datePublished:2010-08-25T00:00:00Z
      dateModified:2010-08-25T00:00:00Z
      pageStart:405
      pageEnd:434
      sameAs:https://doi.org/10.1007/s10555-010-9235-2
      keywords:
         Inflammation
         NF-κB
         Nutraceuticals
         Therapeutics
         Tumorigenesis
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3a_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3b_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig3c_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-010-9235-2/MediaObjects/10555_2010_9235_Fig4_HTML.gif
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Subash C. Gupta
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ji Hye Kim
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sahdeo Prasad
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bharat B. Aggarwal
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:29
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Subash C. Gupta
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Ji Hye Kim
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Sahdeo Prasad
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Bharat B. Aggarwal
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(772)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.58s.

LINK . SPRINGER . COM {}