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Title:
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity | Cancer and Metastasis Reviews
Description:
Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis. However, the same innate leukocytes also participate in anti-tumor immunity and restraint of malignant disease. While many factors regulate the propensity of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their functional capabilities. Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors.
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mainEntity:
headline:Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
description:Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis. However, the same innate leukocytes also participate in anti-tumor immunity and restraint of malignant disease. While many factors regulate the propensity of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their functional capabilities. Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors.
datePublished:2010-04-21T00:00:00Z
dateModified:2010-04-21T00:00:00Z
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Cancer
Inflammation
Lymphocyte
Macrophage
Metastasis
Cancer Research
Oncology
Biomedicine
general
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headline:Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
description:Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis. However, the same innate leukocytes also participate in anti-tumor immunity and restraint of malignant disease. While many factors regulate the propensity of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their functional capabilities. Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors.
datePublished:2010-04-21T00:00:00Z
dateModified:2010-04-21T00:00:00Z
pageStart:309
pageEnd:316
license:https://creativecommons.org/licenses/by-nc/2.0
sameAs:https://doi.org/10.1007/s10555-010-9223-6
keywords:
Cancer
Inflammation
Lymphocyte
Macrophage
Metastasis
Cancer Research
Oncology
Biomedicine
general
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