We are analyzing https://link.springer.com/article/10.1007/s10555-007-9103-x.

Title:
A “class action” against the microenvironment: do cancer cells cooperate in metastasis? | Cancer and Metastasis Reviews
Description:
The authors review how cancer cells may cooperate in metastasis by means of microenvironmental changes. The main mechanisms underlying this cooperation are clustered migration of cancer cells, extracellular matrix degradation, paracrine loops of released signaling factors and/or induction of adhesion molecules on stromal cells. Another critical factor could be temporal cooperation: successive waves of cancer cells may induce progressive conditioning of the microenvironment. The “class action” of cancer cells against the microenvironment involves successive steps of the metastatic process: invasion of the primary tumor microenvironment, collective migration through the extracellular matrix, blood vessel disruption, vascular or lymphatic tumor emboli, establishment of a premetastatic niche by secreted factors and endothelial precursor recruitment, induction of cell adhesion molecule expression in endothelial cells, extravasation, micrometastasis dormancy and establishment of a new growth in distant sites. As a result, after completion of the metastatic process, the series of microenvironmental changes from the primary tumor to the metastatic site may promote colonization of metastases by nonmetastatic cancer cells of the primary tumor.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

cancer, google, scholar, article, pubmed, cas, metastasis, cells, tumor, cell, journal, metastatic, breast, research, reviews, microenvironment, migration, nature, bone, invasion, clinical, bidard, marrow, primary, oncology, biology, progression, pathology, privacy, cookies, content, mechanisms, matrix, international, interactions, liver, analysis, data, publish, search, françoisclément, vincentsalomon, cooperation, adhesion, collective, premetastatic, niche, micrometastasis, access, endothelium,

Topics {✒️}

month download article/chapter françois-clément bidard dynamic hetero-cellular communications jean-yves pierga collective cell movement stromal-derived matrix metalloproteinases tumour-mediated upregulation lung-metastatic cancer cells full article pdf cell–cell interaction e-selectin expression privacy choices/manage cookies collective migration minimal residual disease article bidard premetastatic niche therapeutic aid multicellular resistance carcinoma invasion host proinflammatory response pre-metastatic niche �pre-metastatic niche living mouse liver cell–matrix adhesion related subjects tumor cell motility specific colonization clinical breast cancer cell adhesive interactions tumour metastasis cancer cell interactions primary melanoma explants independent prognostic factor powerful prognostic factor iii breast cancer nature cell biology latent disseminated cells nature clinical practice primary tumor microenvironment metastatic breast cancer clinical cancer research induce progressive conditioning blood vessel disruption real-time observation aacr annual meeting breast cancer cells main mechanisms underlying bone marrow cells molecular cell biology local matrix reorganization

Questions {❓}

A “class action” against the microenvironment: do cancer cells cooperate in metastasis?
A “class action” against the microenvironment: do cancer cells cooperate in metastasis?
Active versus passive mechanisms in metastasis: Do cancer cells crawl into vessels, or are they pushed?
Can detection of circulating tumor cells in peripheral blood provide prognostic data in breast cancer?
Tumour metastasis: Is tissue an issue?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A “class action” against the microenvironment: do cancer cells cooperate in metastasis?
         description:The authors review how cancer cells may cooperate in metastasis by means of microenvironmental changes. The main mechanisms underlying this cooperation are clustered migration of cancer cells, extracellular matrix degradation, paracrine loops of released signaling factors and/or induction of adhesion molecules on stromal cells. Another critical factor could be temporal cooperation: successive waves of cancer cells may induce progressive conditioning of the microenvironment. The “class action” of cancer cells against the microenvironment involves successive steps of the metastatic process: invasion of the primary tumor microenvironment, collective migration through the extracellular matrix, blood vessel disruption, vascular or lymphatic tumor emboli, establishment of a premetastatic niche by secreted factors and endothelial precursor recruitment, induction of cell adhesion molecule expression in endothelial cells, extravasation, micrometastasis dormancy and establishment of a new growth in distant sites. As a result, after completion of the metastatic process, the series of microenvironmental changes from the primary tumor to the metastatic site may promote colonization of metastases by nonmetastatic cancer cells of the primary tumor.
         datePublished:2007-12-08T00:00:00Z
         dateModified:2007-12-08T00:00:00Z
         pageStart:5
         pageEnd:10
         sameAs:https://doi.org/10.1007/s10555-007-9103-x
         keywords:
            Metastasis
            Microenvironment
            Collective migration
            Premetastatic niche
            Cooperation
            Colonization
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-007-9103-x/MediaObjects/10555_2007_9103_Fig1_HTML.gif
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:27
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:François-Clément Bidard
               affiliation:
                     name:Institut Curie
                     address:
                        name:Department of Translational Research, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
                     name:Institut Curie
                     address:
                        name:Department of Medical Oncology, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jean-Yves Pierga
               affiliation:
                     name:Institut Curie
                     address:
                        name:Department of Medical Oncology, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anne Vincent-Salomon
               affiliation:
                     name:Institut Curie
                     address:
                        name:Department of Pathology, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marie-France Poupon
               affiliation:
                     name:Institut Curie
                     address:
                        name:Department of Translational Research, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A “class action” against the microenvironment: do cancer cells cooperate in metastasis?
      description:The authors review how cancer cells may cooperate in metastasis by means of microenvironmental changes. The main mechanisms underlying this cooperation are clustered migration of cancer cells, extracellular matrix degradation, paracrine loops of released signaling factors and/or induction of adhesion molecules on stromal cells. Another critical factor could be temporal cooperation: successive waves of cancer cells may induce progressive conditioning of the microenvironment. The “class action” of cancer cells against the microenvironment involves successive steps of the metastatic process: invasion of the primary tumor microenvironment, collective migration through the extracellular matrix, blood vessel disruption, vascular or lymphatic tumor emboli, establishment of a premetastatic niche by secreted factors and endothelial precursor recruitment, induction of cell adhesion molecule expression in endothelial cells, extravasation, micrometastasis dormancy and establishment of a new growth in distant sites. As a result, after completion of the metastatic process, the series of microenvironmental changes from the primary tumor to the metastatic site may promote colonization of metastases by nonmetastatic cancer cells of the primary tumor.
      datePublished:2007-12-08T00:00:00Z
      dateModified:2007-12-08T00:00:00Z
      pageStart:5
      pageEnd:10
      sameAs:https://doi.org/10.1007/s10555-007-9103-x
      keywords:
         Metastasis
         Microenvironment
         Collective migration
         Premetastatic niche
         Cooperation
         Colonization
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-007-9103-x/MediaObjects/10555_2007_9103_Fig1_HTML.gif
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:27
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:François-Clément Bidard
            affiliation:
                  name:Institut Curie
                  address:
                     name:Department of Translational Research, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:Institut Curie
                  address:
                     name:Department of Medical Oncology, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jean-Yves Pierga
            affiliation:
                  name:Institut Curie
                  address:
                     name:Department of Medical Oncology, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anne Vincent-Salomon
            affiliation:
                  name:Institut Curie
                  address:
                     name:Department of Pathology, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-France Poupon
            affiliation:
                  name:Institut Curie
                  address:
                     name:Department of Translational Research, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:27
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institut Curie
      address:
         name:Department of Translational Research, Institut Curie, Paris, France
         type:PostalAddress
      name:Institut Curie
      address:
         name:Department of Medical Oncology, Institut Curie, Paris, France
         type:PostalAddress
      name:Institut Curie
      address:
         name:Department of Medical Oncology, Institut Curie, Paris, France
         type:PostalAddress
      name:Institut Curie
      address:
         name:Department of Pathology, Institut Curie, Paris, France
         type:PostalAddress
      name:Institut Curie
      address:
         name:Department of Translational Research, Institut Curie, Paris, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:François-Clément Bidard
      affiliation:
            name:Institut Curie
            address:
               name:Department of Translational Research, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
            name:Institut Curie
            address:
               name:Department of Medical Oncology, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jean-Yves Pierga
      affiliation:
            name:Institut Curie
            address:
               name:Department of Medical Oncology, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
      name:Anne Vincent-Salomon
      affiliation:
            name:Institut Curie
            address:
               name:Department of Pathology, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
      name:Marie-France Poupon
      affiliation:
            name:Institut Curie
            address:
               name:Department of Translational Research, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Translational Research, Institut Curie, Paris, France
      name:Department of Medical Oncology, Institut Curie, Paris, France
      name:Department of Medical Oncology, Institut Curie, Paris, France
      name:Department of Pathology, Institut Curie, Paris, France
      name:Department of Translational Research, Institut Curie, Paris, France
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(177)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.62s.

LINK . SPRINGER . COM {}