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month download article/chapter seer-medicare-linked database sylvia wassertheil-smoller & thomas full article pdf jean wactawski-wende jennifer beebe-dimmer privacy choices/manage cookies metabolic risk factors related subjects metabolic syndrome prevalence glucose transport system european prospective investigation case–control study ii endometrial cancer european economic area excluding waist circumference body mass index greater body size adams-campbell ll recreational physical activity visceral adiposity albert einstein college ethics declarations conflict metabolic risk score nutrition examination survey additional information publisher conditions privacy policy national health article cancer endometrial cancer risk electronic supplementary material strong risk factor twofold increased risk gastric cancer risk accepting optional cookies endometrial cancer independent dang cv article log article arthur check access instant access hofstra northwell school risk factors journal finder publish article cite juhua luo indiana university bloomington metabolic syndrome health initiative prospective study

Questions {❓}

• Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB et al (2013) Type I and II endometrial cancer: have they different risk factors?

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      headline:Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study
      description:Obesity is a strong risk factor for endometrial cancer, but it is unclear whether metabolic syndrome (MetS) contributes to endometrial cancer risk over and above the contribution of obesity. We examined the association of MetS and its components with risk of endometrial cancer in a sub-cohort of 24,210 women enrolled in the Women’s Health Initiative cohort study. Two variants of the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS were used: one including and one excluding waist circumference (WC). Cox proportional hazards models were used to estimate the association of the study exposures with disease risk. When WC was included in the definition, MetS showed an approximately two-fold increase in endometrial cancer risk (HR 2.20; 95% CI 1.61–3.02); however, when WC was excluded, MetS was no longer associated with risk. We also observed that women with hyperglycemia, dyslipidemia and hypertension, in combination, had almost a twofold increased risk of endometrial cancer, independent of WC (HR 1.94; 95% CI 1.09, 3.46). Glucose, and, in particular, WC and body mass index were also positively associated with risk. Our findings suggest that MetS may predict risk of endometrial cancer independent of obesity among women with the remaining four Mets components.
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