We are analyzing https://link.springer.com/article/10.1007/s10552-005-1723-2.

Title:
Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers | Cancer Causes & Control
Description:
Objective: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained. We hypothesized that occupational airborne exposures in a traditional male dominated industry might contribute to these observations. Methods: A prospective, large cohort study of Swedish construction workers was linked to the Swedish population-based registers of Cancer, Causes of Death and Total Population. 260,052 men were followed from 1971 through 2000. Industrial hygienists assessed specific exposures for 200 job titles, and occupational airborne exposures were analyzed separately and combined. Incidence rate ratios (IRR), with 95% confidence intervals (CI), were estimated in multivariable Cox regression models adjusted for attained age, calendar period, smoking status and body mass. Results: We found positive associations between high exposure to asbestos (IRR 4.5 [95% CI 1.4–14.3]) and cement dust (IRR 3.8 [95% CI 1.5–9.6]) and risk of esophageal adenocarcinoma. Associations were seen between high exposure to asphalt fumes (IRR 2.3 [95% CI 1.0–5.3]) and wood dust (IRR 4.8 [95% CI 1.2–19.4]) and risk of cardia adenocarcinoma. No consistent associations regarding esophageal squamous-cell carcinoma were found. Conclusions: Exposure to asbestos and cement dust may be risk factors for esophageal adenocarcinoma, and exposure to asphalt fumes and wood dust may increase the risk of cardia adenocarcinoma. However, these associations cannot explain the major sex differences or the increasing incidence trends of these tumors.
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Keywords {🔍}

cancer, google, scholar, pubmed, article, esophageal, workers, med, occupational, risk, gastric, cardia, incidence, adenocarcinoma, exposure, exposures, esophagus, mortality, swedish, sweden, int, ind, construction, lagergren, study, occup, boffetta, cohort, access, health, environ, research, dust, carcinoma, oesophageal, stockholm, privacy, cookies, content, control, bergdahl, irr, nyren, epidemiology, chow, epidemiol, karolinska, department, analysis, publish,

Topics {✒️}

anti-androgenic 5α-reductase inhibitors month download article/chapter esophageal squamous-cell carcinoma squamous cell carcinoma nested case-control study swedish population-based registers mattsson le rutqvist full article pdf russian printing industry swedish construction workers related subjects norell le rutkvist occupational airborne exposures davis db thomas privacy choices/manage cookies public health sciences occupational health construction workers exposed case-control study gastrointestinal cancer mortality gastric cardia int gastric cardia adenocarcinoma french asphalt workers gastric cardia cancers strong male predominance occupational sunlight exposure benzidine dye workers diagnosed cancer cases clinical medicine article cancer continents database int swedish chimney sweeps global overview eur lower esophagus cancer karolinska university hospital european economic area major sex differences check access shaheen df ransohoff sex hormones play gutschow ah holscher iarc sci publ instant access large cohort study population-based cohort article jansson gastrointestinal cancer conditions privacy policy public health occupational exposures

Questions {❓}

J Lagergren O Nyren (1998) Do sex hormones play a role in the etiology of esophageal adenocarcinoma?

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         headline:Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers
         description:Objective: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained. We hypothesized that occupational airborne exposures in a traditional male dominated industry might contribute to these observations. Methods: A prospective, large cohort study of Swedish construction workers was linked to the Swedish population-based registers of Cancer, Causes of Death and Total Population. 260,052 men were followed from 1971 through 2000. Industrial hygienists assessed specific exposures for 200 job titles, and occupational airborne exposures were analyzed separately and combined. Incidence rate ratios (IRR), with 95% confidence intervals (CI), were estimated in multivariable Cox regression models adjusted for attained age, calendar period, smoking status and body mass. Results: We found positive associations between high exposure to asbestos (IRR 4.5 [95% CI 1.4–14.3]) and cement dust (IRR 3.8 [95% CI 1.5–9.6]) and risk of esophageal adenocarcinoma. Associations were seen between high exposure to asphalt fumes (IRR 2.3 [95% CI 1.0–5.3]) and wood dust (IRR 4.8 [95% CI 1.2–19.4]) and risk of cardia adenocarcinoma. No consistent associations regarding esophageal squamous-cell carcinoma were found. Conclusions: Exposure to asbestos and cement dust may be risk factors for esophageal adenocarcinoma, and exposure to asphalt fumes and wood dust may increase the risk of cardia adenocarcinoma. However, these associations cannot explain the major sex differences or the increasing incidence trends of these tumors.
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      headline:Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers
      description:Objective: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained. We hypothesized that occupational airborne exposures in a traditional male dominated industry might contribute to these observations. Methods: A prospective, large cohort study of Swedish construction workers was linked to the Swedish population-based registers of Cancer, Causes of Death and Total Population. 260,052 men were followed from 1971 through 2000. Industrial hygienists assessed specific exposures for 200 job titles, and occupational airborne exposures were analyzed separately and combined. Incidence rate ratios (IRR), with 95% confidence intervals (CI), were estimated in multivariable Cox regression models adjusted for attained age, calendar period, smoking status and body mass. Results: We found positive associations between high exposure to asbestos (IRR 4.5 [95% CI 1.4–14.3]) and cement dust (IRR 3.8 [95% CI 1.5–9.6]) and risk of esophageal adenocarcinoma. Associations were seen between high exposure to asphalt fumes (IRR 2.3 [95% CI 1.0–5.3]) and wood dust (IRR 4.8 [95% CI 1.2–19.4]) and risk of cardia adenocarcinoma. No consistent associations regarding esophageal squamous-cell carcinoma were found. Conclusions: Exposure to asbestos and cement dust may be risk factors for esophageal adenocarcinoma, and exposure to asphalt fumes and wood dust may increase the risk of cardia adenocarcinoma. However, these associations cannot explain the major sex differences or the increasing incidence trends of these tumors.
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      dateModified:
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         adenocarcinoma
         cardia cancer
         construction workers
         esophageal cancer
         occupational exposures
         Cancer Research
         Biomedicine
         general
         Oncology
         Public Health
         Epidemiology
         Hematology
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