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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
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We are analyzing https://link.springer.com/article/10.1007/s10549-010-1163-x.

Title:
HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial | Breast Cancer Research and Treatment
Description:
There is a growing body of evidence that HER2 status can change during disease recurrence or progression in breast cancer patients. In this context, re-evaluation of HER2 status by assessment of HER2 expression on circulating tumor cells (CTCs) is a strategy with potential clinical application. The aim of this trial was to determine the HER2 status of CTCs in metastatic breast cancer patients comparing two CTC assays. A total of 254 patients with metastatic breast cancer from nine German university breast cancer centers were enrolled in this prospective study. HER2 status of CTCs was assessed using both the FDA-approved CellSearch® assay and AdnaTest BreastCancer™. Using the CellSearch assay, 122 of 245 (50%) patients had ≥5 CTCs, and HER2-positive CTCs were observed in 50 (41%) of these patients. Ninety of 229 (39%) patients were CTC positive using AdnaTest BreastCancer, and HER2 positivity rate was 47% (42 of 90). The rate of breast cancer patients with HER2-negative primary tumors but HER2-positive CTCs was 32% (25 of 78) and 49% (28 of 57) using the CellSearch assay and AdnaTest BreastCancer, respectively. Considering only those patients who had CTCs on both tests (n = 62), concordant results regarding HER2 positivity were obtained in 50% of the patients (31/62) (P = 0.96, κ = −0.006). HER2-positive CTCs can be detected in a relevant number of patients with HER2 negative primary tumors. Therefore, it will be mandatory to correlate the assay-dependent HER2 status of CTCs to the clinical response on HER2-targeted therapies.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

cancer, breast, article, google, scholar, pubmed, patients, cas, tumor, circulating, cells, metastatic, status, primary, res, germany, university, receptor, clin, oncol, fehm, department, gynecology, ctcs, obstetrics, study, research, expression, access, data, trial, müller, aktas, cell, human, hayes, miller, privacy, cookies, content, clinical, riethdorf, kasimirbauer, wallwiener, pantel, cellsearch, comparison, metastases, therapy, epidermal,

Topics {✒️}

ck-19/mammaglobin rt-pcr month download article/chapter erbb-related gene encoding epithelial-mesenchymal transition markers nci-eortc working group human breast cancer related subjects franz-josef-strauss-allee 11 tyrosine kinase receptor her2-negative primary tumors breast cancer research metastatic breast cancer clinical oncology/college assay-dependent her2 status anti-her2 therapy management advanced breast cancer full article pdf breast cancer progression breast cancer res fda-approved cellsearch® assay resectable breast cancer recurrent breast cancer breast cancer progresses primary breast cancer van der spoel breast cancer patients triple-receptor measurements circulating epithelial cells privacy choices/manage cookies breast tumor cells unrestricted research grant sabine kasimir-bauer open-label her2-positive ctcs anti-her2 therapy steroid hormone receptors circulating tumour cells van laere sj circulating tumor cells colorectal cancer patients bone marrow micrometastasis her2-targeted therapies check access instant access distant metastatic sites tumor marker studies 000-mr tumour antigen miller medical communications neoadjuvant geparquattro trial unknown her2 status

Questions {❓}

  • Simmons C, Miller N, Geddie W, Gianfelice D, Oldfield M, Dranitsaris G, Clemons MJ (2009) Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?
  • Vincent-Salomon A, Pierga JY, Couturier J, d’Enghien CD, Nos C, Sigal-Zafrani B, Lae M, Fréneaux P, Diéras V, Thiéry JP, Sastre-Garau X (2007) HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management?

Schema {🗺️}

WebPage:
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         headline:HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial
         description:There is a growing body of evidence that HER2 status can change during disease recurrence or progression in breast cancer patients. In this context, re-evaluation of HER2 status by assessment of HER2 expression on circulating tumor cells (CTCs) is a strategy with potential clinical application. The aim of this trial was to determine the HER2 status of CTCs in metastatic breast cancer patients comparing two CTC assays. A total of 254 patients with metastatic breast cancer from nine German university breast cancer centers were enrolled in this prospective study. HER2 status of CTCs was assessed using both the FDA-approved CellSearch® assay and AdnaTest BreastCancer™. Using the CellSearch assay, 122 of 245 (50%) patients had ≥5 CTCs, and HER2-positive CTCs were observed in 50 (41%) of these patients. Ninety of 229 (39%) patients were CTC positive using AdnaTest BreastCancer, and HER2 positivity rate was 47% (42 of 90). The rate of breast cancer patients with HER2-negative primary tumors but HER2-positive CTCs was 32% (25 of 78) and 49% (28 of 57) using the CellSearch assay and AdnaTest BreastCancer, respectively. Considering only those patients who had CTCs on both tests (n = 62), concordant results regarding HER2 positivity were obtained in 50% of the patients (31/62) (P = 0.96, κ = −0.006). HER2-positive CTCs can be detected in a relevant number of patients with HER2 negative primary tumors. Therefore, it will be mandatory to correlate the assay-dependent HER2 status of CTCs to the clinical response on HER2-targeted therapies.
         datePublished:2010-09-22T00:00:00Z
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      headline:HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial
      description:There is a growing body of evidence that HER2 status can change during disease recurrence or progression in breast cancer patients. In this context, re-evaluation of HER2 status by assessment of HER2 expression on circulating tumor cells (CTCs) is a strategy with potential clinical application. The aim of this trial was to determine the HER2 status of CTCs in metastatic breast cancer patients comparing two CTC assays. A total of 254 patients with metastatic breast cancer from nine German university breast cancer centers were enrolled in this prospective study. HER2 status of CTCs was assessed using both the FDA-approved CellSearch® assay and AdnaTest BreastCancer™. Using the CellSearch assay, 122 of 245 (50%) patients had ≥5 CTCs, and HER2-positive CTCs were observed in 50 (41%) of these patients. Ninety of 229 (39%) patients were CTC positive using AdnaTest BreastCancer, and HER2 positivity rate was 47% (42 of 90). The rate of breast cancer patients with HER2-negative primary tumors but HER2-positive CTCs was 32% (25 of 78) and 49% (28 of 57) using the CellSearch assay and AdnaTest BreastCancer, respectively. Considering only those patients who had CTCs on both tests (n = 62), concordant results regarding HER2 positivity were obtained in 50% of the patients (31/62) (P = 0.96, κ = −0.006). HER2-positive CTCs can be detected in a relevant number of patients with HER2 negative primary tumors. Therefore, it will be mandatory to correlate the assay-dependent HER2 status of CTCs to the clinical response on HER2-targeted therapies.
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      dateModified:2010-09-22T00:00:00Z
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         Breast cancer
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                  name:University Hospital of Essen
                  address:
                     name:Department of Gynecology and Obstetrics, University Hospital of Essen, Essen, Germany
                     type:PostalAddress
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            name:Wolfgang Janni
            affiliation:
                  name:University of Düsseldorf
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                     name:Department of Gynecology and Obstetrics, University of Düsseldorf, Düsseldorf, Germany
                     type:PostalAddress
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                     type:PostalAddress
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                     type:PostalAddress
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                     type:PostalAddress
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            name:Christoph Klein
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                  name:University of Regensburg
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            name:University of Homburg
            address:
               name:Department of Gynecology and Obstetrics, University of Homburg, Homburg/Saar, Germany
               type:PostalAddress
            type:Organization
      name:Brigitte Rack
      affiliation:
            name:University of Munich
            address:
               name:Department of Gynecology and Obstetrics, University of Munich, München, Germany
               type:PostalAddress
            type:Organization
      name:Sabine Riethdorf
      affiliation:
            name:University Medical Center Hamburg-Eppendorf
            address:
               name:Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
               type:PostalAddress
            type:Organization
      name:Christoph Klein
      affiliation:
            name:University of Regensburg
            address:
               name:Institute of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany
               type:PostalAddress
            type:Organization
      name:Christian Schindlbeck
      affiliation:
            name:University of Munich
            address:
               name:Department of Gynecology and Obstetrics, University of Munich, München, Germany
               type:PostalAddress
            type:Organization
      name:Kerstin Brocker
      affiliation:
            name:University of Heidelberg
            address:
               name:Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Sabine Kasimir-Bauer
      affiliation:
            name:University Hospital of Essen
            address:
               name:Department of Gynecology and Obstetrics, University Hospital of Essen, Essen, Germany
               type:PostalAddress
            type:Organization
      name:Diethelm Wallwiener
      affiliation:
            name:University of Tübingen
            address:
               name:Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Klaus Pantel
      affiliation:
            name:University Medical Center Hamburg-Eppendorf
            address:
               name:Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany
      name:Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
      name:Department of Gynecology and Obstetrics, University Hospital of Essen, Essen, Germany
      name:Department of Gynecology and Obstetrics, University of Düsseldorf, Düsseldorf, Germany
      name:Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
      name:Department of Gynecology and Obstetrics, University of Freiburg, Freiburg, Germany
      name:Department of Gynecology and Obstetrics, University of Regensburg, Regensburg, Germany
      name:Department of Gynecology and Obstetrics, University of Erlangen, Erlangen, Germany
      name:Department of Gynecology and Obstetrics, University of Homburg, Homburg/Saar, Germany
      name:Department of Gynecology and Obstetrics, University of Munich, München, Germany
      name:Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
      name:Institute of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany
      name:Department of Gynecology and Obstetrics, University of Munich, München, Germany
      name:Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
      name:Department of Gynecology and Obstetrics, University Hospital of Essen, Essen, Germany
      name:Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany
      name:Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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