We are analyzing https://link.springer.com/article/10.1007/s10549-009-0619-3.

Title:
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment | Breast Cancer Research and Treatment
Description:
The concept of cancer cells being hierarchically organized and arising from their own progenitor stem cells will have important implications on cancer therapy. If this hypothesis were to be true then the paucity of estrogen receptors in stem cells as well as their inherent drug resistance mechanisms pose a challenge to current targeted therapies. In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was observed in the postneoadjuvant therapy specimens compared to pretreatment samples. On the other hand, high degree of stromal expression was significantly associated with best disease-free survival as well as a trend for overall survival. The association of stromal expression was confirmed in an independent cohort of triple negative cases. The novel finding is that tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors.
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Keywords {🔍}

cancer, breast, article, google, scholar, cells, pubmed, stem, cas, cell, res, aldh, expression, tumor, research, prognostic, reisfilho, badve, access, clin, wicha, usa, pathology, privacy, cookies, content, microenvironment, resetkova, therapy, resistance, invasive, negative, human, natl, clarke, information, publish, search, impact, nakshatri, marker, series, cases, triple, basallike, aldehyde, dehydrogenase, markers, mammary, inst,

Topics {✒️}

month download article/chapter cancer stem cells—perspectives cd44−/cd24+ tumor cells cancer stem-cell hypothesis aldh1 positive cells triple negative cases reis-filho contributed equally adjuvant anthracycline-treated patients related subjects progenitor stem cells stem/progenitor cells cancer stem cells breast cancer cells invasive breast carcinomas human breast carcinoma human breast tumors full article pdf epithelial-mesenchymal transition breast cancer prevention breast cancer relates invasive breast carcinoma privacy choices/manage cookies her2 tumor types candidate target population metastatic breast cancer her2 gene amplification 245 invasive cancers breast cancers tumor microenvironment high aldehyde dehydrogenase cell mol med anderson cancer center epirubicin-based chemotherapy article resetkova neo-adjuvant chemotherapy cancer research estrogen receptors cd44+/cd24− phenotype reis-filho js distinct molecular signature stem cells european economic area cohorts analyzed included enhanced malignant rodriguez-pinilla sm asselin-labat ml aberrant luminal progenitors brca1 mutation carriers retinal oxidation activity cancer cells

Questions {❓}

O’Brien CS, Farnie G, Howell SJ, Clarke RB (2008) Are stem-like cells responsible for resistance to therapy in breast cancer?

Schema {🗺️}

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         description:The concept of cancer cells being hierarchically organized and arising from their own progenitor stem cells will have important implications on cancer therapy. If this hypothesis were to be true then the paucity of estrogen receptors in stem cells as well as their inherent drug resistance mechanisms pose a challenge to current targeted therapies. In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was observed in the postneoadjuvant therapy specimens compared to pretreatment samples. On the other hand, high degree of stromal expression was significantly associated with best disease-free survival as well as a trend for overall survival. The association of stromal expression was confirmed in an independent cohort of triple negative cases. The novel finding is that tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors.
         datePublished:2009-11-13T00:00:00Z
         dateModified:2009-11-13T00:00:00Z
         pageStart:97
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      description:The concept of cancer cells being hierarchically organized and arising from their own progenitor stem cells will have important implications on cancer therapy. If this hypothesis were to be true then the paucity of estrogen receptors in stem cells as well as their inherent drug resistance mechanisms pose a challenge to current targeted therapies. In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The four cohorts analyzed included an adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and two series of 58 and 40 triple negative cases, respectively. Both tumor cell and stromal expression for ALDH1 was evaluated, where possible. Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in the adjuvant series and tumor grade in the neoadjuvant cohort. No significant enrichment for ALDH1 positive cells was observed in the postneoadjuvant therapy specimens compared to pretreatment samples. On the other hand, high degree of stromal expression was significantly associated with best disease-free survival as well as a trend for overall survival. The association of stromal expression was confirmed in an independent cohort of triple negative cases. The novel finding is that tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors.
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      dateModified:2009-11-13T00:00:00Z
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      pageEnd:108
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         ALDH1
         Breast
         Stem cells
         Tumor microenvironment
         Chemotherapy
         Oncology
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