We are analyzing https://link.springer.com/article/10.1007/s10549-009-0461-7.

Title:
Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients | Breast Cancer Research and Treatment
Description:
Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
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Keywords {🔍}

cancer, breast, article, google, scholar, pubmed, tumor, cells, cas, circulating, patients, status, primary, clin, res, research, blood, metastatic, clinical, ctcs, access, oncol, tumors, herpositive, detection, privacy, cookies, content, silvia, leo, peripheral, disease, prognostic, italy, information, publish, search, correlation, pestrin, bessi, angelo, open, therapy, comparison, treat, unit, prato, data, log, journal,

Topics {✒️}

her2/neu-positive breast cancer month download article/chapter real-time tumor biopsy anti-her2 therapy her2-positive primary tumors her2-negative primary tumors angelo di leo positive ctc sample related subjects advanced breast cancer her2-positive ctcs metastatic breast cancer human breast cancer unknown her2 status full article pdf early breast cancer primary breast cancer breast cancer progresses breast cancer metastases recurrent breast cancer operable breast cancer her2-negative ctcs privacy choices/manage cookies circulating tumor cells breast cancer patients clinical oncology/college biological targeting therapy assessed her2 status epithelial tumor cells circulating tumour cells institutional research program breast cancer progression serum her2 levels cancer markers biostatistics unit ispo check access instant access tumor cells circulate disseminated tumor cells disseminating tumour cells annibale biggeri distant metastatic sites financial support provided tumor markers her2/neu oncogene article pestrin di leo european economic area hayes df specific biological properties

Questions {❓}

Hayes DF, Smerage J (2008) Is there a role for circulating tumor cells in the management of breast cancer?

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         headline:Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
         description:Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
         datePublished:2009-07-12T00:00:00Z
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            HER2 status
            Circulating tumor cells
            Predictive markers
            Anti-HER2 therapies
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      headline:Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
      description:Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
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         HER2 status
         Circulating tumor cells
         Predictive markers
         Anti-HER2 therapies
         Oncology
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