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Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence | Breast Cancer Research and Treatment
Description:
Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of breast cancer and integrate into the tumor stroma. We demonstrate here the effect of hMSCs on primary breast tumor growth and the progression of these tumors to hormone independence. Co-injection of bone marrow-derived hMSCs enhances primary tumor growth of the estrogen receptor-positive, hormone-dependent breast carcinoma cell line MCF-7 in the presence or absence of estrogen in SCID/beige mice. We also show hormone-independent growth of MCF-7 cells when co-injected with hMSCs. These effects were found in conjunction with increased immunohistochemical staining of the progesterone receptor in the MCF-7/hMSC tumors as compared to MCF-7 control tumors. This increase in PgR expression indicates a link between MCF-7 cells and MSCs through ER-mediated signaling. Taken together, our data reveal the relationship between tumor microenvironment and tumor growth and the progression to hormone independence. This tumor stroma-cell interaction may provide a novel target for the treatment of estrogen receptor-positive, hormone-independent, and endocrine-resistant breast carcinoma.
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cells, cancer, article, google, scholar, stem, pubmed, cas, breast, mesenchymal, center, human, tumor, tulane, university, usa, research, growth, department, orleans, tumors, health, sciences, bone, estrogen, carcinoma, cell, mcf, res, stroma, access, privacy, cookies, content, adult, hmscs, mice, receptor, marrow, metastasis, data, publish, search, hormone, independence, marrowderived, progesterone, stromal, factor, nature,
Topics {βοΈ}
mesenchymal stem cells month download article/chapter marrow stromal cells cell line-dependent manner endocrine-resistant breast carcinoma mcf-7/hmsc tumors tumor microenvironment show hormone-independent growth ovarian carcinoma tumorigenesis tumor stroma-cell interaction bone marrow stroma breast cancer metastasis breast cancer micrometastases epithelial tumour cells stem cells stem cells 20 human pancreatic carcinoma full article pdf related subjects tulane cancer center targeted-gene delivery vehicles promote hormone independence carcinoma cells breast cancer estrogen receptor-positive vegf-producing cells tulane university school privacy choices/manage cookies progesterone receptor mcf-7 cells er-mediated signaling check access stromal hyperplasia instant access tumor stroma generation tumor stroma formation 3d tumor environments scid/beige mice site-selective growth targeted-delivery vehicles interferon-beta delivery 1007/s10549-008-0216 european economic area increased immunohistochemical staining erica nierth-simpson electronic supplementary material mcf-7 control tumors tumor growth therapeutic effects anticancer agents
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headline:Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence
description:Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of breast cancer and integrate into the tumor stroma. We demonstrate here the effect of hMSCs on primary breast tumor growth and the progression of these tumors to hormone independence. Co-injection of bone marrow-derived hMSCs enhances primary tumor growth of the estrogen receptor-positive, hormone-dependent breast carcinoma cell line MCF-7 in the presence or absence of estrogen in SCID/beige mice. We also show hormone-independent growth of MCF-7 cells when co-injected with hMSCs. These effects were found in conjunction with increased immunohistochemical staining of the progesterone receptor in the MCF-7/hMSC tumors as compared to MCF-7 control tumors. This increase in PgR expression indicates a link between MCF-7 cells and MSCs through ER-mediated signaling. Taken together, our data reveal the relationship between tumor microenvironment and tumor growth and the progression to hormone independence. This tumor stroma-cell interaction may provide a novel target for the treatment of estrogen receptor-positive, hormone-independent, and endocrine-resistant breast carcinoma.
datePublished:2009-07-12T00:00:00Z
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Mesenchymal stem cells
Breast carcinoma
Progesterone receptor
Stromal-derived factor 1
Tumor microenvironment
Oncology
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headline:Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence
description:Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of breast cancer and integrate into the tumor stroma. We demonstrate here the effect of hMSCs on primary breast tumor growth and the progression of these tumors to hormone independence. Co-injection of bone marrow-derived hMSCs enhances primary tumor growth of the estrogen receptor-positive, hormone-dependent breast carcinoma cell line MCF-7 in the presence or absence of estrogen in SCID/beige mice. We also show hormone-independent growth of MCF-7 cells when co-injected with hMSCs. These effects were found in conjunction with increased immunohistochemical staining of the progesterone receptor in the MCF-7/hMSC tumors as compared to MCF-7 control tumors. This increase in PgR expression indicates a link between MCF-7 cells and MSCs through ER-mediated signaling. Taken together, our data reveal the relationship between tumor microenvironment and tumor growth and the progression to hormone independence. This tumor stroma-cell interaction may provide a novel target for the treatment of estrogen receptor-positive, hormone-independent, and endocrine-resistant breast carcinoma.
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Breast carcinoma
Progesterone receptor
Stromal-derived factor 1
Tumor microenvironment
Oncology
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