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  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
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We are analyzing https://link.springer.com/article/10.1007/s10549-007-9781-7.

Title:
Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients | Breast Cancer Research and Treatment
Description:
Background Data on distant disease-free interval (DDFI) and the localization of the first distant metastasis (DM) in BRCA1- and BRCA2-associated breast cancer (BC) patients are as yet scarcely available. Patients and methods We identified 57 BRCA1-associated and 31 BRCA2-associated BC patients, diagnosed between 1980 and 2001, and developing DM disease before 2004, July 1. DDFI, the site(s) of first DM and post-relapse survival of these patients were compared with those of 192 sporadic BC patients. Results As compared to sporadic patients, BRCA1 patients developed less often bone DM (30% vs. 51%; P = 0.005), but tended to develop more often lung DM (26% vs. 16%; P = 0.07), and DM at multiple sites (44% vs. 32%; P = 0.11). In BRCA2-associated compared to sporadic patients, first DM more commonly occurred in lymph nodes (23% vs. 7%; P = 0.007) and at multiple sites (48% vs. 32%; P = 0.08). Adjuvant systemic therapy appeared to be most effective in BRCA2 mutation carriers. Post-relapse survival was worse for BRCA1- and better for BRCA2-associated patients as compared to sporadic patients, but differences disappeared after adjustment for ER-status, site of first DM and DDFI. Conclusion The site of first DM is different between BRCA1- and BRCA2-associated and sporadic BC patients. Differences in post-relapse survival could be explained by differences in site of first DM, in ER-status and in DDFI. Treatment efficacy may differ dependent on genetic status.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Science
  • Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

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Keywords {🔍}

cancer, breast, brca, article, google, scholar, pubmed, cas, patients, survival, brcaassociated, sporadic, site, van, mutations, oncol, res, distant, compared, seynaeve, differences, clin, treatment, diseasefree, relapse, postrelapse, brekelmans, metastasis, mutation, privacy, cookies, content, data, research, interval, ddfi, carriers, status, access, receptor, characteristics, clinical, publish, search, kriege, meijersheijboer, related, cancers, estrogen, hereditary,

Topics {✒️}

distant disease-free interval month download article/chapter tilanus-linthorst & bert van geel van den ouweland hanne meijers-heijboer brca1-related breast cancer bert van geel full article pdf breast cancer metastasis cancer genomics center post-relapse survival sporadic breast cancers privacy choices/manage cookies developing dm disease hereditary breast cancer breast cancer relapse margriet collee van putten wl russian breast cancer familial breast cancer metastatic breast cancer operable breast cancer erasmus mc dutch cancer society vu medical center primary breast cancer breast-cancer patients brca1/brca2 mutation status distant metastasis breast carcinomas arising related subjects tilanus-linthorst mm cancers involving brca1 breast-conserving treatment comprehensive mutation screening article kriege european economic area brca mutation status chappuis po sledge gw jr foulkes wd highly increased incidence dna repair defect brca mutant cells reis-filho js meijers-heijboer immunohistochemical characteristics defined conditions privacy policy brca mutational status tumor dissemination pattern

Schema {🗺️}

WebPage:
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         headline:Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients
         description:Background Data on distant disease-free interval (DDFI) and the localization of the first distant metastasis (DM) in BRCA1- and BRCA2-associated breast cancer (BC) patients are as yet scarcely available. Patients and methods We identified 57 BRCA1-associated and 31 BRCA2-associated BC patients, diagnosed between 1980 and 2001, and developing DM disease before 2004, July 1. DDFI, the site(s) of first DM and post-relapse survival of these patients were compared with those of 192 sporadic BC patients. Results As compared to sporadic patients, BRCA1 patients developed less often bone DM (30% vs. 51%; P = 0.005), but tended to develop more often lung DM (26% vs. 16%; P = 0.07), and DM at multiple sites (44% vs. 32%; P = 0.11). In BRCA2-associated compared to sporadic patients, first DM more commonly occurred in lymph nodes (23% vs. 7%; P = 0.007) and at multiple sites (48% vs. 32%; P = 0.08). Adjuvant systemic therapy appeared to be most effective in BRCA2 mutation carriers. Post-relapse survival was worse for BRCA1- and better for BRCA2-associated patients as compared to sporadic patients, but differences disappeared after adjustment for ER-status, site of first DM and DDFI. Conclusion The site of first DM is different between BRCA1- and BRCA2-associated and sporadic BC patients. Differences in post-relapse survival could be explained by differences in site of first DM, in ER-status and in DDFI. Treatment efficacy may differ dependent on genetic status.
         datePublished:2007-10-19T00:00:00Z
         dateModified:2007-10-19T00:00:00Z
         pageStart:303
         pageEnd:311
         sameAs:https://doi.org/10.1007/s10549-007-9781-7
         keywords:
            BRCA1
            BRCA2
            Breast cancer
            Distant disease-free interval
            Post-relapse survival
            Site of first relapse
            Oncology
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                        name:Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
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                        name:Family Cancer Clinic, Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
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                     name:Erasmus MC-Daniel den Hoed Cancer Center
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                        name:Family Cancer Clinic, Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
                        type:PostalAddress
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               name:Cecile T. M. Brekelmans
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                     name:Erasmus MC-Daniel den Hoed Cancer Center
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                        name:Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
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      headline:Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients
      description:Background Data on distant disease-free interval (DDFI) and the localization of the first distant metastasis (DM) in BRCA1- and BRCA2-associated breast cancer (BC) patients are as yet scarcely available. Patients and methods We identified 57 BRCA1-associated and 31 BRCA2-associated BC patients, diagnosed between 1980 and 2001, and developing DM disease before 2004, July 1. DDFI, the site(s) of first DM and post-relapse survival of these patients were compared with those of 192 sporadic BC patients. Results As compared to sporadic patients, BRCA1 patients developed less often bone DM (30% vs. 51%; P = 0.005), but tended to develop more often lung DM (26% vs. 16%; P = 0.07), and DM at multiple sites (44% vs. 32%; P = 0.11). In BRCA2-associated compared to sporadic patients, first DM more commonly occurred in lymph nodes (23% vs. 7%; P = 0.007) and at multiple sites (48% vs. 32%; P = 0.08). Adjuvant systemic therapy appeared to be most effective in BRCA2 mutation carriers. Post-relapse survival was worse for BRCA1- and better for BRCA2-associated patients as compared to sporadic patients, but differences disappeared after adjustment for ER-status, site of first DM and DDFI. Conclusion The site of first DM is different between BRCA1- and BRCA2-associated and sporadic BC patients. Differences in post-relapse survival could be explained by differences in site of first DM, in ER-status and in DDFI. Treatment efficacy may differ dependent on genetic status.
      datePublished:2007-10-19T00:00:00Z
      dateModified:2007-10-19T00:00:00Z
      pageStart:303
      pageEnd:311
      sameAs:https://doi.org/10.1007/s10549-007-9781-7
      keywords:
         BRCA1
         BRCA2
         Breast cancer
         Distant disease-free interval
         Post-relapse survival
         Site of first relapse
         Oncology
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-007-9781-7/MediaObjects/10549_2007_9781_Fig1_HTML.gif
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                  address:
                     name:Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands
                     type:PostalAddress
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            name:J. Margriet Collee
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                  address:
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                     type:PostalAddress
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                  address:
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                     name:Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
                     type:PostalAddress
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            address:
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            name:Erasmus MC-Daniel den Hoed Cancer Center
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            name:Erasmus MC-Daniel den Hoed Cancer Center
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      affiliation:
            name:Erasmus MC-Daniel den Hoed Cancer Center
            address:
               name:Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Jan G. M. Klijn
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            name:Erasmus MC-Daniel den Hoed Cancer Center
            address:
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      name:Family Cancer Clinic, Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Clinical Genetics, VU Medical Center, Amsterdam, The Netherlands
      name:Family Cancer Clinic, Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
      name:Family Cancer Clinic, Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
      name:Family Cancer Clinic, Department of Surgery, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
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