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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
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We are analyzing https://link.springer.com/article/10.1007/s10549-006-9317-6.

Title:
Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases | Breast Cancer Research and Treatment
Description:
Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and regional metastases, we have analyzed by comparative genomic hybridization 122 tissue samples from altogether 60 breast cancer patients, including 34 tumor samples obtained from different quadrants of 9 breast carcinomas, as well as paired primary-metastatic samples from 12 patients. The median intratumor genetic heterogeneity score (HS) was 17.4% and unsupervised hierarchical clustering analysis comparing the genetic features to those of an independent series of 41 breast carcinomas confirmed intratumor clonal divergence in a high proportion of cases. The median HS between paired primary breast tumors and lymph node metastases was 33.3%, but the number of genomic imbalances did not differ significantly. Clustering analysis confirmed extensive clonal divergence between primary carcinomas and lymph node metastases in several cases. In the independent series of 41 breast carcinomas, the number of genomic imbalances in primary tumors was significantly higher in patients presenting lymph node metastases (median = 15.5) than in the group with no evidence of disease spreading at diagnosis (median = 5.0). We conclude that primary breast carcinomas may be composed of several genetically heterogeneous and spatially separated cell populations and that paired primary breast tumors and lymph node metastases often present divergent clonal evolution, indicating that metastases may occur relatively early during breast carcinogenesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

cancer, breast, google, scholar, article, pubmed, cas, genomic, primary, clonal, carcinomas, heterogeneity, metastases, teixeira, genetic, patients, lymph, comparative, analysis, hybridization, res, node, tumors, chromosomes, pandis, intratumor, heim, tissue, tumor, genes, normal, pathol, privacy, cookies, content, research, divergence, manuel, samples, access, dna, publish, search, torres, ribeiro, median, number, imbalances, cell, prognostic,

Topics {✒️}

month download article/chapter node-negative breast cancer rikshospitalet-radiumhospitalet medical center intratumor genomic heterogeneity comparative genomic hybridization paired primary-metastatic samples breast cancer metastasis primary breast cancers lymph node metastases comparative genomic hybridisation full article pdf hierarchical clustering analysis tumor cell populations breast cancer patients privacy choices/manage cookies metastasis-free survival dna stemline heterogeneity human breast cancer metastatic breast cancer breast cancer polyclonality teixeira mr primary breast carcinomas nonmalignant breast tissue disparate clonal populations normal breast tissue flow cytometric analysis norwegian cancer society genomic imbalances detected tumor heterogeneity extra-tumorous samples related subjects portuguese oncology institute genetic aberrations detected european economic area world health organization standard reference intervals s-phase fraction combined chromosome banding liga portuguesa contra saint savas hospital breast carcinoma revealed normal tissue adjacent dna sequence losses conditions privacy policy clonal heterogeneity article torres genetic heterogeneity epithelial carcinogenesis disagree intratumor variability asynchronous metastasis

Schema {🗺️}

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         headline:Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases
         description:Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and regional metastases, we have analyzed by comparative genomic hybridization 122 tissue samples from altogether 60 breast cancer patients, including 34 tumor samples obtained from different quadrants of 9 breast carcinomas, as well as paired primary-metastatic samples from 12 patients. The median intratumor genetic heterogeneity score (HS) was 17.4% and unsupervised hierarchical clustering analysis comparing the genetic features to those of an independent series of 41 breast carcinomas confirmed intratumor clonal divergence in a high proportion of cases. The median HS between paired primary breast tumors and lymph node metastases was 33.3%, but the number of genomic imbalances did not differ significantly. Clustering analysis confirmed extensive clonal divergence between primary carcinomas and lymph node metastases in several cases. In the independent series of 41 breast carcinomas, the number of genomic imbalances in primary tumors was significantly higher in patients presenting lymph node metastases (median = 15.5) than in the group with no evidence of disease spreading at diagnosis (median = 5.0). We conclude that primary breast carcinomas may be composed of several genetically heterogeneous and spatially separated cell populations and that paired primary breast tumors and lymph node metastases often present divergent clonal evolution, indicating that metastases may occur relatively early during breast carcinogenesis.
         datePublished:2006-08-09T00:00:00Z
         dateModified:2006-08-09T00:00:00Z
         pageStart:143
         pageEnd:155
         sameAs:https://doi.org/10.1007/s10549-006-9317-6
         keywords:
            Breast cancer
            Comparative genomic hybridization
            Intratumor genetic heterogeneity
            Primary tumor
            Lymph node metastasis
            Oncology
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      headline:Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases
      description:Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and regional metastases, we have analyzed by comparative genomic hybridization 122 tissue samples from altogether 60 breast cancer patients, including 34 tumor samples obtained from different quadrants of 9 breast carcinomas, as well as paired primary-metastatic samples from 12 patients. The median intratumor genetic heterogeneity score (HS) was 17.4% and unsupervised hierarchical clustering analysis comparing the genetic features to those of an independent series of 41 breast carcinomas confirmed intratumor clonal divergence in a high proportion of cases. The median HS between paired primary breast tumors and lymph node metastases was 33.3%, but the number of genomic imbalances did not differ significantly. Clustering analysis confirmed extensive clonal divergence between primary carcinomas and lymph node metastases in several cases. In the independent series of 41 breast carcinomas, the number of genomic imbalances in primary tumors was significantly higher in patients presenting lymph node metastases (median = 15.5) than in the group with no evidence of disease spreading at diagnosis (median = 5.0). We conclude that primary breast carcinomas may be composed of several genetically heterogeneous and spatially separated cell populations and that paired primary breast tumors and lymph node metastases often present divergent clonal evolution, indicating that metastases may occur relatively early during breast carcinogenesis.
      datePublished:2006-08-09T00:00:00Z
      dateModified:2006-08-09T00:00:00Z
      pageStart:143
      pageEnd:155
      sameAs:https://doi.org/10.1007/s10549-006-9317-6
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         Breast cancer
         Comparative genomic hybridization
         Intratumor genetic heterogeneity
         Primary tumor
         Lymph node metastasis
         Oncology
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         name:Breast Cancer Research and Treatment
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                     name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
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            name:Franclim R. Ribeiro
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                     name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
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         name:Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
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         name:Medical Faculty, University of Oslo, Oslo, Norway
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         name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
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      name:Johan A. Andersen
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Pathology, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Sverre Heim
      affiliation:
            name:Rikshospitalet-Radiumhospitalet Medical Center
            address:
               name:Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
               type:PostalAddress
            type:Organization
            name:University of Oslo
            address:
               name:Medical Faculty, University of Oslo, Oslo, Norway
               type:PostalAddress
            type:Organization
      name:Manuel R. Teixeira
      affiliation:
            name:Portuguese Oncology Institute
            address:
               name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
               type:PostalAddress
            type:Organization
            name:University of Porto
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      name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
      name:Department of Genetics, Saint Savas Hospital, Athens, Greece
      name:Department of Pathology, Odense University Hospital, Odense, Denmark
      name:Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
      name:Medical Faculty, University of Oslo, Oslo, Norway
      name:Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
      name:Institute of Biomedical Sciences, University of Porto, Porto, Portugal
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External Links {🔗}(127)

Analytics and Tracking {📊}

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