We are analyzing https://link.springer.com/article/10.1007/s10549-005-0672-5.

Title:
Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer | Breast Cancer Research and Treatment
Description:
We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR–RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.
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Keywords {🔍}

cancer, article, brca, breast, rad, pubmed, google, scholar, risk, dna, genes, polymorphism, gene, research, polymorphisms, lodz, privacy, cookies, content, access, repair, poland, publish, search, blasiak, association, carriers, analysis, data, information, log, journal, sliwinski, krupa, majsterek, rykala, kolacinska, morawiec, drzewoski, zadrozny, janusz, variants, discover, genetic, genetics, nature, download, author, springer, optional,

Topics {✒️}

month download article/chapter population-based studies conducted gene-gene interaction davies sc west breast cancer risk brca2-met1915thr thr/thr ireneusz majsterek & janusz blasiak case-control study related subjects brca1 carriers full article pdf privacy choices/manage cookies dna repair genes breast cancer brca1/2 variants molecular genetics genetic polymorphisms brca2 carriers brca2-rad51 complex single-nucleotide polymorphism single nucleotide polymorphism her2 gene polymorphisms rab163/mouse brca2 european economic area hamburger ra eeles albrecht ds lim copeland na jenkins lalande fw alt guanidine isothiocyanate acid enewold pg shields chorazy cc harris modan sm ebbers chetrit gh yechezkel author correspondence dna analysis poznan conditions privacy policy dna repair check access instant access article sliwinski accepting optional cookies radiation hypersensitivity mediated rad51 gene brca2 gene janusz blasiak cancer occurrence met/val article log journal finder publish clinical pharmacology

Schema {🗺️}

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      headline:Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer
      description:We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR–RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.
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