We are analyzing https://link.springer.com/article/10.1007/s10549-004-1720-2.

Title:
A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer | Breast Cancer Research and Treatment
Description:
Background. Epidermal growth factor receptor (EGFR) is considered to be a viable drug target in a variety of solid tumors. The clinical benefit and safety of the EGFR tyrosine kinase inhibitor gefitinib (‘Iressa’)1 was evaluated in this Phase II, multicentre study of patients with taxane and anthracycline pretreated, metastatic breast cancer. Methods. Gefitinib (500 mg/day) was given to 58 patients until disease progression. Primary endpoint was the clinical response rate to the study treatment. Results. One patient (1.7%) had objective partial tumor response of her liver and pleural metastasis. Fifty-seven patients (98.3%) were non-responders with 52 patients (89.7%) having progressive disease and five patients (8.6%) were not evaluable. Two patients reported a significant improvement in pain at metastatic sites (1 liver, 1 bone). The median time to progression was 61 days (95% CI : 54–82 days) and the proportion of patients alive and progression free at 6 months at trial closure was 1.8% (95% CI : 0.0–5.2%). The median survival time was 357 days (95% CI : 257–441 days). Fifty-four patients (93.1%) discontinued study medication prematurely due to disease progression and three (5.2%) due to adverse events (diarrhea, pruritus, peripheral edema). Conclusions. Gefitinib monotherapy at 500 mg daily did not appear to be efficacious in the treatment of heavily pretreated metastatic breast cancer patients. It was well tolerated and the side effect profile was as expected from current knowledge of the drug. There was no correlation between EGFR expression and response in this study.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cancer, breast, google, scholar, cas, pubmed, article, patients, metastatic, phase, study, gefitinib, oncol, treatment, clin, growth, factor, receptor, trial, minckwitz, epidermal, inhibitor, research, access, privacy, cookies, content, tyrosine, kinase, iressa, response, results, chemotherapy, therapy, publish, search, jonat, andreas, egfr, solid, safety, progression, days, advanced, doxorubicin, randomized, multicenter, lung, data, european,

Topics {✒️}

er/her2-positive breast cancer metastatic breast cancer-report month download article/chapter kaufmann hj luck cancer therapy-breast small-cell lung cancer small-cell lung cancer metastatic breast cancer cancer therapy scale andreas du bois related subjects gunter von minckwitz hans-joachim lück full article pdf metastatic cervical cancer neu-isenburg/frankfurt egfr inhibitor gefitinib fgfr inhibitor azd4547 privacy choices/manage cookies national cancer institute janicke dg kieback gynaekologische onkologie phase iii trial breast cancer anthracycline pretreated frauenklinik der mhh henriettenstiftung neu-bethesda european economic area kuhn ae schindler staedtisches klinikum magdeburg open-label s-phase fraction peter fasching oral capecitabine tumor pharmacodynamic study check access instant access jörn hilfrich side effect profile marty jl misset ochs pm lorusso baum gp magquire shaughnessy jl misset fehrenbacher dj slamon murphy wf novotny shak sj stewart additive antitumour effect horst-schmidt-kliniken line therapy conditions privacy policy

Questions {❓}

LJ Fallowfield M Baum GP Magquire (1987) Do psychological studies upset patients?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer
         description:Background. Epidermal growth factor receptor (EGFR) is considered to be a viable drug target in a variety of solid tumors. The clinical benefit and safety of the EGFR tyrosine kinase inhibitor gefitinib (‘Iressa’)1 was evaluated in this Phase II, multicentre study of patients with taxane and anthracycline pretreated, metastatic breast cancer. Methods. Gefitinib (500 mg/day) was given to 58 patients until disease progression. Primary endpoint was the clinical response rate to the study treatment. Results. One patient (1.7%) had objective partial tumor response of her liver and pleural metastasis. Fifty-seven patients (98.3%) were non-responders with 52 patients (89.7%) having progressive disease and five patients (8.6%) were not evaluable. Two patients reported a significant improvement in pain at metastatic sites (1 liver, 1 bone). The median time to progression was 61 days (95% CI : 54–82 days) and the proportion of patients alive and progression free at 6 months at trial closure was 1.8% (95% CI : 0.0–5.2%). The median survival time was 357 days (95% CI : 257–441 days). Fifty-four patients (93.1%) discontinued study medication prematurely due to disease progression and three (5.2%) due to adverse events (diarrhea, pruritus, peripheral edema). Conclusions. Gefitinib monotherapy at 500 mg daily did not appear to be efficacious in the treatment of heavily pretreated metastatic breast cancer patients. It was well tolerated and the side effect profile was as expected from current knowledge of the drug. There was no correlation between EGFR expression and response in this study.
         datePublished:
         dateModified:
         pageStart:165
         pageEnd:172
         sameAs:https://doi.org/10.1007/s10549-004-1720-2
         keywords:
            gefitinib
            metastatic breast cancer
            phase II
            taxane-pretreated
            Oncology
         image:
         isPartOf:
            name:Breast Cancer Research and Treatment
            issn:
               1573-7217
               0167-6806
            volumeNumber:89
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Kluwer Academic Publishers
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Gunter von Minckwitz
               affiliation:
                     name:German Breast Group/Universitäts-Frauenklinik Frankfurt
                     address:
                        name:German Breast Group/Universitäts-Frauenklinik Frankfurt, Neu-Isenburg/Frankfurt, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Walter Jonat
               affiliation:
                     name:Universitaetsklinikum Kiel
                     address:
                        name:Klinik fuer Gynaekologie und Geburtshilfe, Universitaetsklinikum Kiel, Kiel
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter Fasching
               affiliation:
                     name:Universitaetsklinikum Erlangen
                     address:
                        name:Klinik fuer Frauenheilkunde, Universitaetsklinikum Erlangen, Erlangen
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andreas du Bois
               affiliation:
                     name:Dr.-Horst-Schmidt-Kliniken
                     address:
                        name:Klinik fuer Gynaekologie und Gynaekologische Onkologie, Dr.-Horst-Schmidt-Kliniken, Wiesbaden
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ulrich Kleeberg
               affiliation:
                     name:Haematologisch-onkologische Praxis Altona
                     address:
                        name:Haematologisch-onkologische Praxis Altona, Hamburg
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hans-Joachim Lück
               affiliation:
                     name:Krankenhaus Oststadt, Frauenklinik der MHH
                     address:
                        name:Abt. Gynaekologische Onkologie, Krankenhaus Oststadt, Frauenklinik der MHH, Hannover
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Erika Kettner
               affiliation:
                     name:Staedtisches Klinikum Magdeburg
                     address:
                        name:Haematologische Abteilung, Staedtisches Klinikum Magdeburg, Magdeburg
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jörn Hilfrich
               affiliation:
                     name:Henriettenstiftung Neu-Bethesda
                     address:
                        name:Standort Kirchrode, Gynaekologie, Henriettenstiftung Neu-Bethesda, Hannover
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wolfgang Eiermann
               affiliation:
                     name:Frauenklinik vom Roten Kreuz
                     address:
                        name:Frauenklinik vom Roten Kreuz, Munich
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julie Torode
               affiliation:
                     name:AstraZeneca GmbH
                     address:
                        name:AstraZeneca GmbH, Wedel
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andreas Schneeweiss
               affiliation:
                     name:Universitaetsklinikum Heidelberg
                     address:
                        name:Universitaetsklinikum Heidelberg, Frauenklinik, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer
      description:Background. Epidermal growth factor receptor (EGFR) is considered to be a viable drug target in a variety of solid tumors. The clinical benefit and safety of the EGFR tyrosine kinase inhibitor gefitinib (‘Iressa’)1 was evaluated in this Phase II, multicentre study of patients with taxane and anthracycline pretreated, metastatic breast cancer. Methods. Gefitinib (500 mg/day) was given to 58 patients until disease progression. Primary endpoint was the clinical response rate to the study treatment. Results. One patient (1.7%) had objective partial tumor response of her liver and pleural metastasis. Fifty-seven patients (98.3%) were non-responders with 52 patients (89.7%) having progressive disease and five patients (8.6%) were not evaluable. Two patients reported a significant improvement in pain at metastatic sites (1 liver, 1 bone). The median time to progression was 61 days (95% CI : 54–82 days) and the proportion of patients alive and progression free at 6 months at trial closure was 1.8% (95% CI : 0.0–5.2%). The median survival time was 357 days (95% CI : 257–441 days). Fifty-four patients (93.1%) discontinued study medication prematurely due to disease progression and three (5.2%) due to adverse events (diarrhea, pruritus, peripheral edema). Conclusions. Gefitinib monotherapy at 500 mg daily did not appear to be efficacious in the treatment of heavily pretreated metastatic breast cancer patients. It was well tolerated and the side effect profile was as expected from current knowledge of the drug. There was no correlation between EGFR expression and response in this study.
      datePublished:
      dateModified:
      pageStart:165
      pageEnd:172
      sameAs:https://doi.org/10.1007/s10549-004-1720-2
      keywords:
         gefitinib
         metastatic breast cancer
         phase II
         taxane-pretreated
         Oncology
      image:
      isPartOf:
         name:Breast Cancer Research and Treatment
         issn:
            1573-7217
            0167-6806
         volumeNumber:89
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Kluwer Academic Publishers
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Gunter von Minckwitz
            affiliation:
                  name:German Breast Group/Universitäts-Frauenklinik Frankfurt
                  address:
                     name:German Breast Group/Universitäts-Frauenklinik Frankfurt, Neu-Isenburg/Frankfurt, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Walter Jonat
            affiliation:
                  name:Universitaetsklinikum Kiel
                  address:
                     name:Klinik fuer Gynaekologie und Geburtshilfe, Universitaetsklinikum Kiel, Kiel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter Fasching
            affiliation:
                  name:Universitaetsklinikum Erlangen
                  address:
                     name:Klinik fuer Frauenheilkunde, Universitaetsklinikum Erlangen, Erlangen
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas du Bois
            affiliation:
                  name:Dr.-Horst-Schmidt-Kliniken
                  address:
                     name:Klinik fuer Gynaekologie und Gynaekologische Onkologie, Dr.-Horst-Schmidt-Kliniken, Wiesbaden
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ulrich Kleeberg
            affiliation:
                  name:Haematologisch-onkologische Praxis Altona
                  address:
                     name:Haematologisch-onkologische Praxis Altona, Hamburg
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hans-Joachim Lück
            affiliation:
                  name:Krankenhaus Oststadt, Frauenklinik der MHH
                  address:
                     name:Abt. Gynaekologische Onkologie, Krankenhaus Oststadt, Frauenklinik der MHH, Hannover
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Erika Kettner
            affiliation:
                  name:Staedtisches Klinikum Magdeburg
                  address:
                     name:Haematologische Abteilung, Staedtisches Klinikum Magdeburg, Magdeburg
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jörn Hilfrich
            affiliation:
                  name:Henriettenstiftung Neu-Bethesda
                  address:
                     name:Standort Kirchrode, Gynaekologie, Henriettenstiftung Neu-Bethesda, Hannover
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wolfgang Eiermann
            affiliation:
                  name:Frauenklinik vom Roten Kreuz
                  address:
                     name:Frauenklinik vom Roten Kreuz, Munich
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julie Torode
            affiliation:
                  name:AstraZeneca GmbH
                  address:
                     name:AstraZeneca GmbH, Wedel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas Schneeweiss
            affiliation:
                  name:Universitaetsklinikum Heidelberg
                  address:
                     name:Universitaetsklinikum Heidelberg, Frauenklinik, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research and Treatment
      issn:
         1573-7217
         0167-6806
      volumeNumber:89
Organization:
      name:Kluwer Academic Publishers
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:German Breast Group/Universitäts-Frauenklinik Frankfurt
      address:
         name:German Breast Group/Universitäts-Frauenklinik Frankfurt, Neu-Isenburg/Frankfurt, Germany
         type:PostalAddress
      name:Universitaetsklinikum Kiel
      address:
         name:Klinik fuer Gynaekologie und Geburtshilfe, Universitaetsklinikum Kiel, Kiel
         type:PostalAddress
      name:Universitaetsklinikum Erlangen
      address:
         name:Klinik fuer Frauenheilkunde, Universitaetsklinikum Erlangen, Erlangen
         type:PostalAddress
      name:Dr.-Horst-Schmidt-Kliniken
      address:
         name:Klinik fuer Gynaekologie und Gynaekologische Onkologie, Dr.-Horst-Schmidt-Kliniken, Wiesbaden
         type:PostalAddress
      name:Haematologisch-onkologische Praxis Altona
      address:
         name:Haematologisch-onkologische Praxis Altona, Hamburg
         type:PostalAddress
      name:Krankenhaus Oststadt, Frauenklinik der MHH
      address:
         name:Abt. Gynaekologische Onkologie, Krankenhaus Oststadt, Frauenklinik der MHH, Hannover
         type:PostalAddress
      name:Staedtisches Klinikum Magdeburg
      address:
         name:Haematologische Abteilung, Staedtisches Klinikum Magdeburg, Magdeburg
         type:PostalAddress
      name:Henriettenstiftung Neu-Bethesda
      address:
         name:Standort Kirchrode, Gynaekologie, Henriettenstiftung Neu-Bethesda, Hannover
         type:PostalAddress
      name:Frauenklinik vom Roten Kreuz
      address:
         name:Frauenklinik vom Roten Kreuz, Munich
         type:PostalAddress
      name:AstraZeneca GmbH
      address:
         name:AstraZeneca GmbH, Wedel
         type:PostalAddress
      name:Universitaetsklinikum Heidelberg
      address:
         name:Universitaetsklinikum Heidelberg, Frauenklinik, Heidelberg, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Gunter von Minckwitz
      affiliation:
            name:German Breast Group/Universitäts-Frauenklinik Frankfurt
            address:
               name:German Breast Group/Universitäts-Frauenklinik Frankfurt, Neu-Isenburg/Frankfurt, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Walter Jonat
      affiliation:
            name:Universitaetsklinikum Kiel
            address:
               name:Klinik fuer Gynaekologie und Geburtshilfe, Universitaetsklinikum Kiel, Kiel
               type:PostalAddress
            type:Organization
      name:Peter Fasching
      affiliation:
            name:Universitaetsklinikum Erlangen
            address:
               name:Klinik fuer Frauenheilkunde, Universitaetsklinikum Erlangen, Erlangen
               type:PostalAddress
            type:Organization
      name:Andreas du Bois
      affiliation:
            name:Dr.-Horst-Schmidt-Kliniken
            address:
               name:Klinik fuer Gynaekologie und Gynaekologische Onkologie, Dr.-Horst-Schmidt-Kliniken, Wiesbaden
               type:PostalAddress
            type:Organization
      name:Ulrich Kleeberg
      affiliation:
            name:Haematologisch-onkologische Praxis Altona
            address:
               name:Haematologisch-onkologische Praxis Altona, Hamburg
               type:PostalAddress
            type:Organization
      name:Hans-Joachim Lück
      affiliation:
            name:Krankenhaus Oststadt, Frauenklinik der MHH
            address:
               name:Abt. Gynaekologische Onkologie, Krankenhaus Oststadt, Frauenklinik der MHH, Hannover
               type:PostalAddress
            type:Organization
      name:Erika Kettner
      affiliation:
            name:Staedtisches Klinikum Magdeburg
            address:
               name:Haematologische Abteilung, Staedtisches Klinikum Magdeburg, Magdeburg
               type:PostalAddress
            type:Organization
      name:Jörn Hilfrich
      affiliation:
            name:Henriettenstiftung Neu-Bethesda
            address:
               name:Standort Kirchrode, Gynaekologie, Henriettenstiftung Neu-Bethesda, Hannover
               type:PostalAddress
            type:Organization
      name:Wolfgang Eiermann
      affiliation:
            name:Frauenklinik vom Roten Kreuz
            address:
               name:Frauenklinik vom Roten Kreuz, Munich
               type:PostalAddress
            type:Organization
      name:Julie Torode
      affiliation:
            name:AstraZeneca GmbH
            address:
               name:AstraZeneca GmbH, Wedel
               type:PostalAddress
            type:Organization
      name:Andreas Schneeweiss
      affiliation:
            name:Universitaetsklinikum Heidelberg
            address:
               name:Universitaetsklinikum Heidelberg, Frauenklinik, Heidelberg, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:German Breast Group/Universitäts-Frauenklinik Frankfurt, Neu-Isenburg/Frankfurt, Germany
      name:Klinik fuer Gynaekologie und Geburtshilfe, Universitaetsklinikum Kiel, Kiel
      name:Klinik fuer Frauenheilkunde, Universitaetsklinikum Erlangen, Erlangen
      name:Klinik fuer Gynaekologie und Gynaekologische Onkologie, Dr.-Horst-Schmidt-Kliniken, Wiesbaden
      name:Haematologisch-onkologische Praxis Altona, Hamburg
      name:Abt. Gynaekologische Onkologie, Krankenhaus Oststadt, Frauenklinik der MHH, Hannover
      name:Haematologische Abteilung, Staedtisches Klinikum Magdeburg, Magdeburg
      name:Standort Kirchrode, Gynaekologie, Henriettenstiftung Neu-Bethesda, Hannover
      name:Frauenklinik vom Roten Kreuz, Munich
      name:AstraZeneca GmbH, Wedel
      name:Universitaetsklinikum Heidelberg, Frauenklinik, Heidelberg, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(97)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.25s.

LINK . SPRINGER . COM {}