We are analyzing https://link.springer.com/article/10.1007/s10529-012-1036-y.

Title:
Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells | Biotechnology Letters
Description:
A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
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article, lee, google, scholar, pubmed, cas, liver, receptor, lipid, belamcanda, chinensis, lxr, cholesterol, research, korea, iristectorigenin, jun, privacy, cookies, content, expression, macrophage, cells, hoang, access, information, publish, search, biotechnology, modulator, abcg, woo, hwang, accumulation, genes, chem, res, kim, forest, science, south, data, log, journal, isolated, abca, heejin, minhhien, jia, seo,

Topics {✒️}

month download article/chapter lxr-α/-β-responsive genes sung-joon lee bang yeon hwang woo-duck seo stz-induced diabetic rats jin woo lee receptor ligands—competitive recruitment dong-ho lee hak-ju lee inhibits protein kinase full article pdf sterol-dependent transactivation privacy choices/manage cookies minh-hien hoang immune modulation independently national research foundation dual-lxr agonist ji-hae lee suppressed cholesterol accumulation forest resources utilization lxr modulator access korean forest service cellular cholesterol handling induces cholesterol efflux european economic area dose-dependent manner fatty acid synthase stearoyl-coa desaturase-1 abcg family members potential active faction green business management affecting lipid accumulation article jun conditions privacy policy coronary heart disease anti-tumor activities author information authors lee jh bile acid metabolism electronic supplementary material hea-won kim technology development program chungbuk national university β article 10 accepting optional cookies inducing liver steatosis main content log journal finder publish article log

Schema {🗺️}

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         headline:Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells
         description:A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
         datePublished:2012-09-26T00:00:00Z
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            Cholesterol
            Iristectorigenin B
            LXR modulator
            Microbiology
            Biotechnology
            Applied Microbiology
            Biochemistry
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      headline:Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells
      description:A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
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         Cholesterol
         Iristectorigenin B
         LXR modulator
         Microbiology
         Biotechnology
         Applied Microbiology
         Biochemistry
         general
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      name:Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
      name:Division of Green Business Management, Department of Forest Resources Utilization, Korean Forest Research Institute, Seoul, South Korea
      name:Department of Functional Crop, National Institute of Crop Science, Miryang, South Korea
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      name:Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
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