We are analyzing https://link.springer.com/article/10.1007/s10522-011-9324-9.

Title:
The role of autophagy in genetic pathways influencing ageing | Biogerontology
Description:
Autophagy is a conserved cellular degradation pathway for the breakdown of cytosolic macromolecules and organelles. Constitutive autophagy has a housekeeping role and is essential for survival, development and metabolic regulation. Autophagy is also responsive to stress and can degrade damaged proteins and organelles, oxidized lipids and intracellular pathogens. Defects in the autophagic degradation system are linked to disease pathogenesis and ageing. Different signalling pathways converge on autophagy to regulate lifespan in diverse organisms. We discuss recent findings that provide insight into the cross-talk between this critical regulator of metabolic homeostasis and molecular mechanisms that promote longevity.
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Keywords {🔍}

article, google, scholar, pubmed, cas, autophagy, cell, elegans, life, biol, genes, lifespan, tavernarakis, span, nature, drosophila, ageing, longevity, aging, protein, restriction, death, role, development, extension, caenorhabditis, pathway, tor, science, levine, regulation, disease, yeast, dev, nat, privacy, essential, cookies, content, research, pathways, markaki, kinase, rapamycin, signaling, mice, mizushima, kaeberlein, publish, search,

Topics {✒️}

month download article/chapter spermidine promotes longevity powers rw iii longevity-promoting factor skn-1 resveratrol promote longevity life span-prolonging effect caloric restriction full article pdf article biogerontology aims tor signaling pathway insulin signaling pathway tor pathway interacts rapamycin fed late privacy choices/manage cookies age-related decline chaperone-mediated autophagy european research council calorie restriction work drosophila life span article markaki neurodegeneration induces upregulation tor kinase extending life span chronological life span metabolic homeostasis signalling pathways converge insulin/insulin nektarios tavernarakis autophagic degradation system p53 extends life-span longevity pathways converge european economic area axonal homeostasis check access instant access autophagy genes mediate autophagy protein atg7 degrade damaged proteins discuss recent findings pyrazinamidase/nicotinamidase ptdins3k dunn wa jr polyglutamine expansion proteins salmonella typhimurium infection long-lived mutants central nervous system friedrich vl jr food-derived odors sirtuin-1- dependent induction mimics transcriptional aspects

Questions {❓}

Hands SL, Proud CG, Wyttenbach A (2009) mTOR’s role in ageing: protein synthesis or autophagy?
Koubova J, Guarente L (2003) How does calorie restriction work?
Madeo F, Tavernarakis N, Kroemer G (2010) Can autophagy promote longevity?
Tavernarakis N (2008) Ageing and the regulation of protein synthesis: a balancing act?

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