We are analyzing https://link.springer.com/article/10.1007/s10495-010-0469-9.

Title:
Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells | Apoptosis
Description:
One of the ultimate goals in transplantation is to develop novel therapeutic methods for induction of donor-specific tolerance to reduce the side effects caused by the generalized immunosuppression associated to the currently used pharmacologic regimens. Interaction or phagocytosis of cells in early apoptosis exerts potent anti-inflammatory and immunosuppressive effects on antigen (Ag)-presenting cells (APC) like dendritic cells (DC) and macrophages. This observation led to the idea that apoptotic cell-based therapies could be employed to deliver donor-Ag in combination with regulatory signals to recipient’s APC as therapeutic approach to restrain the anti-donor response. This review describes the multiple mechanisms by which apoptotic cells down-modulate the immuno-stimulatory and pro-inflammatory functions of DC and macrophages, and the role of the interaction between apoptotic cells and APC in self-tolerance and in apoptotic cell-based therapies to prevent/treat allograft rejection and graft-versus-host disease in murine experimental systems and in humans. It also explores the role that in vivo-generated apoptotic cells could have in the beneficial effects of extracorporeal photopheresis, donor-specific transfusion, and tolerogenic DC-based therapies in transplantation.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, apoptotic, google, scholar, article, pubmed, cas, cell, transplantation, dendritic, donor, apc, recipients, effect, rejection, vivo, effects, therapies, response, mice, immunol, tolerance, allograft, transplant, macrophages, photopheresis, immune, immature, peripheral, immunosuppressive, function, survival, leukocytes, splenocytes, apoptosis, mechanisms, extracorporeal, med, regulatory, exp, cardiac, indirect, treg, administration, blood, role, therapeutic, immunoregulatory, secretion, ecp,

Topics {✒️}

chronic graft-versus-host disease anti-apoptotic protein bcl-xl apoptotic cell-derived allo-peptides graft-versus-host disease patients class i-restricted cross-presentation anti-inflammatory/immuno-suppressive mediators anti-cd3 ab-induced immunosuppression pro-inflammatory cytokines il-1α apoptotic cell-derived allo-ag graft-versus-host disease graft-versus-host-disease growth arrest-specific gene-6 uv-b-irradiated splenocytes injected long-term immune tolerance anti-cd3 monoclonal ab promote th2-biased responses cell-based therapies previously cutaneous t-cell lymphoma anti-cd3 ab immunotherapy donor-derived apoptotic leukocytes long-tern allograft survival apoptotic cell-based therapies tgf-β secretion resulted long-term pharmacological immunosuppression pre-formed circulating antibodies monocyte-derived dendritic cells anti-donor allo-antibodies living cell-based therapies article download pdf releasing pro-inflammatory mediators clodronate liposomes abrogated promote donor-specific immunosuppression immature/semi-mature dc mitogen-activated protein kinase clonal t-cell exhaustion induce donor-specific immunosuppression mhc class-ii ag donor-derived apoptotic cells pro-inflammatory mediators released tolerogenic dc-based therapies cell-based therapies employed mononuclear cell-enriched fraction end-stage organ disorders allogeneic bone-marrow accelerated fas-mediated apoptosis keratin-stripped human epidermis immature/semi-mature apc stomach-draining lymph nodes systemic ag-specific immunoregulation donor-specific immunosuppressive therapies

Questions {❓}

Albert M (2004) Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
How do apoptotic cells control the immunostimulatory function of APC?
In this regard, it would be interesting to know: what is the probability of triggering autoimmunity or causing allo-sensitization in transplant recipients following single or repetitive administration of apoptotic cells?
Rizzo R, Melchiorri L, Tazzari PL, Tassi C, Soli M, Lunghi M, Belloni M, Conte R, Baricordi OR (2005) Increased production of soluble HLA-G molecules in stimulated peripheral blood mononuclear cells following extracorporeal photopheresis: is it a mechanisms involved in the therapeutic effect of the procedure?

Schema {🗺️}

WebPage:
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         headline:Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells
         description:One of the ultimate goals in transplantation is to develop novel therapeutic methods for induction of donor-specific tolerance to reduce the side effects caused by the generalized immunosuppression associated to the currently used pharmacologic regimens. Interaction or phagocytosis of cells in early apoptosis exerts potent anti-inflammatory and immunosuppressive effects on antigen (Ag)-presenting cells (APC) like dendritic cells (DC) and macrophages. This observation led to the idea that apoptotic cell-based therapies could be employed to deliver donor-Ag in combination with regulatory signals to recipient’s APC as therapeutic approach to restrain the anti-donor response. This review describes the multiple mechanisms by which apoptotic cells down-modulate the immuno-stimulatory and pro-inflammatory functions of DC and macrophages, and the role of the interaction between apoptotic cells and APC in self-tolerance and in apoptotic cell-based therapies to prevent/treat allograft rejection and graft-versus-host disease in murine experimental systems and in humans. It also explores the role that in vivo-generated apoptotic cells could have in the beneficial effects of extracorporeal photopheresis, donor-specific transfusion, and tolerogenic DC-based therapies in transplantation.
         datePublished:2010-02-06T00:00:00Z
         dateModified:2010-02-06T00:00:00Z
         pageStart:1083
         pageEnd:1097
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            Dendritic cells
            Extracorporeal photopheresis
            Cancer Research
            Cell Biology
            Oncology
            Biochemistry
            general
            Virology
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ScholarlyArticle:
      headline:Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells
      description:One of the ultimate goals in transplantation is to develop novel therapeutic methods for induction of donor-specific tolerance to reduce the side effects caused by the generalized immunosuppression associated to the currently used pharmacologic regimens. Interaction or phagocytosis of cells in early apoptosis exerts potent anti-inflammatory and immunosuppressive effects on antigen (Ag)-presenting cells (APC) like dendritic cells (DC) and macrophages. This observation led to the idea that apoptotic cell-based therapies could be employed to deliver donor-Ag in combination with regulatory signals to recipient’s APC as therapeutic approach to restrain the anti-donor response. This review describes the multiple mechanisms by which apoptotic cells down-modulate the immuno-stimulatory and pro-inflammatory functions of DC and macrophages, and the role of the interaction between apoptotic cells and APC in self-tolerance and in apoptotic cell-based therapies to prevent/treat allograft rejection and graft-versus-host disease in murine experimental systems and in humans. It also explores the role that in vivo-generated apoptotic cells could have in the beneficial effects of extracorporeal photopheresis, donor-specific transfusion, and tolerogenic DC-based therapies in transplantation.
      datePublished:2010-02-06T00:00:00Z
      dateModified:2010-02-06T00:00:00Z
      pageStart:1083
      pageEnd:1097
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s10495-010-0469-9
      keywords:
         Transplantation
         Tolerance
         Apoptotic cells
         Dendritic cells
         Extracorporeal photopheresis
         Cancer Research
         Cell Biology
         Oncology
         Biochemistry
         general
         Virology
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                     name:Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA
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      name:Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA
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      name:Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, USA
      name:Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, USA

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