We are analyzing https://link.springer.com/article/10.1007/s10495-008-0244-3.

Title:
Protection of human colon epithelial cells against deoxycholate by rottlerin | Apoptosis
Description:
The bile salt, deoxycholate (DOC), can harm cells and cause disease. Hence, there is interest in identifying compounds capable of protecting cells against DOC. In HCT-116 colon epithelial cells, DOC increased generation of reactive oxygen species and caused DNA damage and apoptosis. These effects of DOC were inhibited by rottlerin, which is a phenolic compound of plant origin. In elucidating its mechansim, rottlerin prevented the release of cytochrome c from mitochondria into cytosol, and also prevented the cleavage of caspase-3. Yet, rottlerin by itself markedly decreased mitochondrial membrane potential and increased mitochondrial superoxide production, but this did not result in cytochrome c release or in caspase-3 cleavage. At a higher test concentration, two other phenolic phytochemicals, namely, quercetin and resveratrol, were each able to largely prevent the occurrence of apoptosis in cells exposed to DOC. In contrast, epigallocatechin gallate, curcumin, and genistein were ineffective.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter nuclear factor-kappab activation pkc-delta-independent pathway nqo1 suppression-enhanced sensitivity short-chain fatty acids related subjects apoptotic cell death article apoptosis aims scfa-induced apoptosis hydrophobic bile acids full article pdf colon epithelial cells deoxycholate-induced apoptosis haematopoietic cell lines deoxycholate-induced colitis privacy choices/manage cookies longpre & george loo phenolic compound protein kinase inhibitors national research initiative human gastric cells protein kinase inhibitor human gastrointestinal cancers cell death article longpre mitochondrial membrane depolarization cell proliferation activity gene expression profiles bile acids isolated rat hepatocytes hepatic mitochondria exposed mitochondrial intermembrane proteins mitochondrial permeability transition cell culture media pkc delta inhibitor european economic area identifying compounds capable reactive oxygen species caused dna damage higher test concentration vivo biological activities dodonaea viscosa flowers cholestatic liver diseases sing-yeung ka high fat consumption winklhofer-roob bm wild-type p53 stable free radical tyrosine phosphorylation s-nitrosylated proteins

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         description:The bile salt, deoxycholate (DOC), can harm cells and cause disease. Hence, there is interest in identifying compounds capable of protecting cells against DOC. In HCT-116 colon epithelial cells, DOC increased generation of reactive oxygen species and caused DNA damage and apoptosis. These effects of DOC were inhibited by rottlerin, which is a phenolic compound of plant origin. In elucidating its mechansim, rottlerin prevented the release of cytochrome c from mitochondria into cytosol, and also prevented the cleavage of caspase-3. Yet, rottlerin by itself markedly decreased mitochondrial membrane potential and increased mitochondrial superoxide production, but this did not result in cytochrome c release or in caspase-3 cleavage. At a higher test concentration, two other phenolic phytochemicals, namely, quercetin and resveratrol, were each able to largely prevent the occurrence of apoptosis in cells exposed to DOC. In contrast, epigallocatechin gallate, curcumin, and genistein were ineffective.
         datePublished:2008-07-26T00:00:00Z
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      headline:Protection of human colon epithelial cells against deoxycholate by rottlerin
      description:The bile salt, deoxycholate (DOC), can harm cells and cause disease. Hence, there is interest in identifying compounds capable of protecting cells against DOC. In HCT-116 colon epithelial cells, DOC increased generation of reactive oxygen species and caused DNA damage and apoptosis. These effects of DOC were inhibited by rottlerin, which is a phenolic compound of plant origin. In elucidating its mechansim, rottlerin prevented the release of cytochrome c from mitochondria into cytosol, and also prevented the cleavage of caspase-3. Yet, rottlerin by itself markedly decreased mitochondrial membrane potential and increased mitochondrial superoxide production, but this did not result in cytochrome c release or in caspase-3 cleavage. At a higher test concentration, two other phenolic phytochemicals, namely, quercetin and resveratrol, were each able to largely prevent the occurrence of apoptosis in cells exposed to DOC. In contrast, epigallocatechin gallate, curcumin, and genistein were ineffective.
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         Cancer Research
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