We are analyzing https://link.springer.com/article/10.1007/s10439-005-2503-6.

Title:
Neutrophil Migration in Opposing Chemoattractant Gradients Using Microfluidic Chemotaxis Devices | Annals of Biomedical Engineering
Description:
Neutrophils migrating in tissue respond to complex overlapping signals generated by a variety of chemotactic factors (CFs). Previous studies suggested a hierarchy between bacteria-derived CFs and host-derived CFs but could not differentiate neutrophil response to potentially equal host-derived CFs (IL-8 and LTB4). This paper reports neutrophil migration in conflicting gradients of IL-8 and LTB4 using a microfluidic chemotaxis device that can generate stable and well-defined gradients. We quantitatively characterized the movement of cells from time-lapse images. Neutrophils migrate more efficiently toward single IL-8 gradients than single LTB4 gradients as measured by the effective chemotactic index (ECI). In opposing gradients of IL-8 and LTB4, neutrophils show obvious chemotaxis toward a distant gradient, consistent with previous reports. When an opposing gradient of LTB4 is present, neutrophils show less effective chemotaxis toward IL-8 than when they are in a gradient of IL-8 alone. In contrast, the chemotactic response of neutrophils to LTB4 is not reduced in opposing gradients as compared to that in a single LTB4 gradient. These results indicate that the presence of one host-derived CF modifies the response of neutrophils to a second CF suggesting a subtle hierarchy between them.
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Keywords {🔍}

article, google, scholar, cas, pubmed, cell, chemotaxis, gradients, migration, chemotactic, neutrophil, microfluidic, biol, irvine, jeon, neutrophils, ltb, opposing, privacy, cookies, content, lin, gradient, access, leukocyte, publish, search, biomedical, engineering, nguyen, wang, gross, noo, phd, cfs, hierarchy, university, california, data, information, log, journal, research, francis, saadi, steven, signals, hostderived, response, cells,

Topics {✒️}

month download article/chapter related subjects host-derived cf modifies neutrophil migration connie minh-canh nguyen divergent migratory patterns effective neutrophil chemotaxis microfluidic chemotaxis devices microfluidic chemotaxis device full article pdf differentiate neutrophil response human polymorphonuclear leukocytes privacy choices/manage cookies host-derived cfs tissue cell chemotaxis ngf-induced chemotaxis protein signaling events spontaneous migration coordinating cell responses bacteria-derived cfs biomedical engineering aims article lin european economic area time-lapse images gaba-induced chemokinesis collagen gel assay rho family proteins {alpha}1-antitrypsin deficiency article annals conditions privacy policy trends cell biol opposing chemoattractant gradients sputum chemotactic activity effective chemotactic index opposing chemotactic gradients check access instant access accepting optional cookies shur-jen wang single ltb4 gradient migration wajeeh saadi article log single ltb4 gradients microfluidic networks microfluidic systems single il-8 gradients previous studies suggested journal finder publish gross department

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      headline:Neutrophil Migration in Opposing Chemoattractant Gradients Using Microfluidic Chemotaxis Devices
      description:Neutrophils migrating in tissue respond to complex overlapping signals generated by a variety of chemotactic factors (CFs). Previous studies suggested a hierarchy between bacteria-derived CFs and host-derived CFs but could not differentiate neutrophil response to potentially equal host-derived CFs (IL-8 and LTB4). This paper reports neutrophil migration in conflicting gradients of IL-8 and LTB4 using a microfluidic chemotaxis device that can generate stable and well-defined gradients. We quantitatively characterized the movement of cells from time-lapse images. Neutrophils migrate more efficiently toward single IL-8 gradients than single LTB4 gradients as measured by the effective chemotactic index (ECI). In opposing gradients of IL-8 and LTB4, neutrophils show obvious chemotaxis toward a distant gradient, consistent with previous reports. When an opposing gradient of LTB4 is present, neutrophils show less effective chemotaxis toward IL-8 than when they are in a gradient of IL-8 alone. In contrast, the chemotactic response of neutrophils to LTB4 is not reduced in opposing gradients as compared to that in a single LTB4 gradient. These results indicate that the presence of one host-derived CF modifies the response of neutrophils to a second CF suggesting a subtle hierarchy between them.
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